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公开(公告)号:US5061705A
公开(公告)日:1991-10-29
申请号:US476875
申请日:1990-02-08
IPC分类号: A61K31/00 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/496 , A61K31/50 , A61K31/505 , A61P17/00 , A61P17/10 , A61P29/00 , A61P35/00 , C07D207/32 , C07D207/323 , C07D207/325 , C07D207/337 , C07D231/06 , C07D231/12 , C07D231/20 , C07D231/22 , C07D231/24 , C07D233/54 , C07D233/64 , C07D233/84 , C07D237/08 , C07D239/36 , C07D261/08 , C07D263/04 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/20 , C07D277/22 , C07D277/30 , C07D307/36 , C07D307/38 , C07D307/40 , C07D307/54 , C07D333/08 , C07D333/18 , C07D333/24 , C07D521/00
CPC分类号: C07D207/323 , C07D207/325 , C07D207/337 , C07D231/06 , C07D231/12 , C07D231/22 , C07D231/24 , C07D233/64 , C07D233/84 , C07D237/08 , C07D239/36 , C07D261/08 , C07D263/04 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/107 , C07D277/30 , C07D307/36 , C07D307/38 , C07D307/40 , C07D307/54 , C07D333/08 , C07D333/18 , C07D333/24 , Y10S514/844 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/915
摘要: Compounds of formula I ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom,R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group,R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy,R.sup.5 is hydrogen or methoxy or tert-butyl,R.sup.6 is hydrogen, methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.20 -alkanoyl or is benzoyl which is unsubstituted or substituted by methoxy, nitro, methyl or chlorine,R.sup.9 and R.sup.10 are each hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.6 -alkanoyl or are each benzoyl which is unsubstituted or substituted as for R.sup.8, or R.sup.9 and R.sup.10, together with the nitrogen atom to which they are bonded, form a saturated, 5-membered or 6-membered heterocyclic radical which may contain oxygen as the second heteroatom,R.sup.11 is hydrogen, C.sub.1 -C.sub.4 -alkyl, --OR.sup.13 or --NR.sup.14 R.sup.15, where R.sup.13 is hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.8 -alkyl, aryl or aralkyl which is unsubstituted or substituted by chlorine, bromine, methyl, methoxy or nitro, substitution in the case of the aralkyl group being in the aryl moiety, and where R.sup.14 and R.sup.15 are each hydrogen, unsubstituted or hydroxyl-substituted C.sub.1 -C.sub.6 -alkyl or an aralkyl or aryl group which is unsubstituted or substituted as for R.sup.13, or R.sup.14 and R.sup.15, together with the nitrogen atom to which they are bonded, form a heterocyclic radical as defined above for R.sup.9 and R.sup.10, andR.sup.12 is C.sub.1 -C.sub.4 -alkyl,and compounds of formula Ia ##STR3## where R.sup.3, R.sup.4, R.sup.6 and L have the abovementioned meanings and R.sup.17 is hydrogen or hydroxyl, and their physiologically tolerated salts, processes for their preparation and drugs and cosmetics prepared therefrom.