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    Device for the optical imaging of a sample
    1.
    发明授权
    Device for the optical imaging of a sample 有权

    公开(公告)号：US09759661B2

    公开(公告)日：2017-09-12

    申请号：US13055755

    申请日：2009-02-12

    申请人： Hans-Ulrich Dodt

    发明人： Hans-Ulrich Dodt

    IPC分类号： G01N21/64 ,  G02B21/00 ,  G01N15/02 ,  G02B1/16

    CPC分类号： G01N21/6458 ,  G01N15/0205 ,  G01N21/6486 ,  G02B1/16 ,  G02B21/0076

    摘要： In a device for the optical imaging of a sample, having at least one light source for excitation light in order to excite a fluorescent dye in a sample, which is held by a sample holder, for spontaneous emission of fluorescent light over a limited period of time in a spatial region having increased resolution, and for de-excitation light in order to de-excite the fluorescent dye again except for a residual zone that is reduced in size relative to the spatial region, wherein light from the sample having wavelengths other than those of the excitation light and of the de-excitation light is assignable to the spontaneous emission of fluorescent light from the residual zone of the spatial region (STED, GSD, etc.), the de-excitation light (3) is arranged to be transmitted in two parallel planes which are separated by a gap (2).

    HISTOLOGICAL METHOD
    2.
    发明申请
    HISTOLOGICAL METHOD 有权
    组织学方法

    公开(公告)号：US20130023008A1

    公开(公告)日：2013-01-24

    申请号：US13637916

    申请日：2011-03-17

    申请人： Klaus Becker ,  Hans-Ulrich Dodt ,  Nina Jährling

    发明人： Klaus Becker ,  Hans-Ulrich Dodt ,  Nina Jährling

    IPC分类号： G01N1/30 ,  C12N5/071 ,  C12N5/07

    CPC分类号： G01N1/30

    摘要： The invention relates to the technical field of the histological preparation of biological tissue comprising a method and means for preparing transparent biological specimens for examination under a light microscope.

    摘要翻译： 本发明涉及生物组织的组织学制备的技术领域，其包括在光学显微镜下制备用于检查的透明生物样品的方法和装置。

    Monitoring Neuronal Signals
    3.
    发明申请
    Monitoring Neuronal Signals 审中-公开
    监测神经元信号

    公开(公告)号：US20080234597A1

    公开(公告)日：2008-09-25

    申请号：US12067622

    申请日：2006-09-20

    申请人： Klaus Becker ,  Andreas Ranft ,  Walter Ziegiginsberger ,  Matthias Eder ,  Hans-Ulrich Dodt

    发明人： Klaus Becker ,  Andreas Ranft ,  Walter Ziegiginsberger ,  Matthias Eder ,  Hans-Ulrich Dodt

    IPC分类号： A61B5/0476

    CPC分类号： A61B5/4821 ,  A61B5/04012 ,  A61B5/0476

    摘要： A monitoring device for monitoring an individual under investigation comprises a recording device for recording a neuronal signal from the individual, and a calculating device for calculating a parameter representing a quantitative measure of an anaesthesia or coma condition of the individual and being derived from the neuronal signal, wherein the calculating device is adapted for calculating a complexity parameter representing the quantitative measure of the anaesthesia or coma condition, and the calculating device includes a buffer circuit for storing at least one time series of the neuronal signal and an analysis circuit for subjecting the time series to a recurrence quantification analysis (RQA) providing the complexity parameter. Furthermore, a method includes estimating a parameter representing a quantitative measure of an anaesthesia or coma condition of an individual.

    摘要翻译： 用于监测正在研究的个体的监视装置包括用于记录来自个体的神经元信号的记录装置，以及用于计算表示个体的麻醉或昏迷状况的定量测量的参数的计算装置，并从神经元信号 其特征在于，所述计算装置适于计算代表所述麻醉或昏迷状态的定量测量的复杂度参数，所述计算装置包括用于存储所述神经信号的至少一个时间序列的缓冲电路和用于使所述时间 系列提供复杂度参数的复发量化分析（RQA）。 此外，一种方法包括估计表示个体的麻醉或昏迷状况的定量测量的参数。

    Histological method
    5.
    发明授权
    Histological method 有权
    组织学方法

    公开(公告)号：US08956827B2

    公开(公告)日：2015-02-17

    申请号：US13637916

    申请日：2011-03-17

    申请人： Klaus Becker ,  Hans-Ulrich Dodt ,  Nina Jährling

    发明人： Klaus Becker ,  Hans-Ulrich Dodt ,  Nina Jährling

    IPC分类号： G01N1/30 ,  C12N5/07

    CPC分类号： G01N1/30

    摘要： The invention relates to the technical field of the histological preparation of biological tissue comprising a method and means for preparing transparent biological specimens for examination under a light microscope.

    摘要翻译： 本发明涉及生物组织的组织学制备的技术领域，包括用于制备透明生物样品以在光学显微镜下检查的方法和手段。

    Device for the Optical Imaging of a Sample
    7.
    发明申请
    Device for the Optical Imaging of a Sample 审中-公开
    样品光学成像装置

    公开(公告)号：US20110186754A1

    公开(公告)日：2011-08-04

    申请号：US13055755

    申请日：2009-02-12

    申请人： Hans-Ulrich Dodt

    发明人： Hans-Ulrich Dodt

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6458 ,  G01N15/0205 ,  G01N21/6486 ,  G02B1/16 ,  G02B21/0076

    摘要： In a device for the optical imaging of a sample, having at least one light source for excitation light in order to excite a fluorescent dye in a sample, which is held by a sample holder, for spontaneous emission of fluorescent light over a limited period of time in a spatial region having increased resolution, and for de-excitation light in order to de-excite the fluorescent dye again except for a residual zone that is reduced in size relative to the spatial region, wherein light from the sample having wavelengths other than those of the excitation light and of the de-excitation light is assignable to the spontaneous emission of fluorescent light from the residual zone of the spatial region (STED, GSD, etc.), the de-excitation light (3) is arranged to be transmitted in two parallel planes which are separated by a gap (2).

    摘要翻译： 在用于样品的光学成像的装置中，具有用于激发光的至少一个光源，以激发由样品保持器保持的样品中的荧光染料，用于在有限的时间段内自发发射荧光 在具有增加的分辨率的空间区域中的时间，以及用于去激发光，以便除了相对于空间区域减小尺寸的残留区域之外，再次去除荧光染料，其中来自具有波长以外的波长的样品的光 激发光和去激发光的那些可以分配给从空间区域（STED，GSD等）的残留区域发出的荧光的自发发射，去激发光（3）被布置为 在由间隙（2）分开的两个平行平面中传输。