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1.发明授权Crosslinked human or animal tissue products and their methods of manufacture and use 有权交联的人或动物组织产品及其制造和使用方法公开(公告)号：US09592320B2
公开(公告)日：2017-03-14
申请号：US14527571
申请日：2014-10-29
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
IPC分类号： C09H1/00 , A61L27/24 , A61K38/39 , A61K38/17 , A61K38/16 , A61L27/36 , A61L27/54 , A61L27/58 , C07K14/78
CPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/3687 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2430/34 , A61L2430/40
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
摘要翻译： 提供由具有胺基和酯基交联的胶原基材料制成的可降解生物预处理方法，以及它们的形成和使用方法。 本发明的一些实施方案涉及一种控制基于胶原的材料中胺基交联与酯基交联的比例以提供可定制交联的胶原基材料的方法。 一些实施方案提供了制备可降解生物假体的方法，其涉及控制交联以提供部分交联的可降解生物假体。 通过控制胺类与酯类交联的比例，通过控制交联水平，或通过控制这两个特征，可以合成具有定制降解速率的可降解生物预处理。 可降解生物预处理的一些实施方案具有被定制以允许其在特定医疗应用中使用的降解速率。 一些实施方案涉及在伤口愈合，组织修复和组织补充中使用可降解生物假体的方法。
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公开(公告)号：US20170204162A1
公开(公告)日：2017-07-20
申请号：US15422158
申请日：2017-02-01
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
CPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/3687 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2430/34 , A61L2430/40
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
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公开(公告)号：US20160303285A1
公开(公告)日：2016-10-20
申请号：US15191957
申请日：2016-06-24
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
CPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/3687 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2430/34 , A61L2430/40
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
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公开(公告)号：US20200299357A1
公开(公告)日：2020-09-24
申请号：US16834824
申请日：2020-03-30
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
IPC分类号： C07K14/78 , A61K38/39 , A61K38/17 , A61K38/16 , A61L27/24 , A61L27/36 , A61L27/54 , A61L27/58
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
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公开(公告)号：US12065480B2
公开(公告)日：2024-08-20
申请号：US16834824
申请日：2020-03-30
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
IPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/36 , A61L27/54 , A61L27/58
CPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/3687 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2430/34 , A61L2430/40
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
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6.发明申请CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE 有权交联的人或动物组织产品及其制造和使用方法公开(公告)号：US20150065429A1
公开(公告)日：2015-03-05
申请号：US14527571
申请日：2014-10-29
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
CPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/3687 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2430/34 , A61L2430/40
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
摘要翻译： 提供由具有胺基和酯基交联的胶原基材料制成的可降解生物预处理方法，以及它们的形成和使用方法。 本发明的一些实施方案涉及一种控制基于胶原的材料中胺基交联与酯基交联的比例以提供可定制交联的胶原基材料的方法。 一些实施方案提供了制备可降解生物假体的方法，其涉及控制交联以提供部分交联的可降解生物假体。 通过控制胺类与酯类交联的比例，通过控制交联水平，或通过控制这两个特征，可以合成具有定制降解速率的可降解生物预处理。 可降解生物预处理的一些实施方案具有被定制以允许其在特定医疗应用中使用的降解速率。 一些实施方案涉及在伤口愈合，组织修复和组织补充中使用可降解生物假体的方法。
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公开(公告)号：US12102731B2
公开(公告)日：2024-10-01
申请号：US17245782
申请日：2021-04-30
申请人： Harbor MedTech, Inc.
CPC分类号： A61L27/24 , A61F2/0811 , C08L89/06 , A61F2002/0858 , A61F2220/0075 , A61F2230/0008 , A61F2230/0023 , A61F2230/0026 , A61L2430/10
摘要： Disclosed herein are embodiments of a reinforced collagen matrix device for superior capsule repair. The device can include a collagen matrix cover, a first reinforcement strip positioned along the first side of the cover, and a second reinforcement strip positioned along the second side of the cover. A first end and a second end of the first and second reinforcement strips can extend past the first end and the second end of the collagen matrix cover so as not be covered by the collagen matrix cover. The collagen matrix cover can be folded along a first fold and a second fold and extend over the first and second reinforcement strips so that a portion of the first and second reinforcement strips are covered by the collagen matrix cover along a portion of the length of the first reinforcement strip.
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公开(公告)号：US20220280690A1
公开(公告)日：2022-09-08
申请号：US17684196
申请日：2022-03-01
申请人： Harbor MedTech, Inc.
摘要： Disclosed herein are embodiments of orthopedic devices. In several embodiments, orthopedic device comprises a biocompatible covering. In several embodiments the biocompatible covering is a collagen-based material. In several embodiments, the collagen-based material is crosslinked using an epoxide-based crosslinking agent (e.g., a diepoxide, triepoxide, etc.). In several embodiments, after a precursor crosslinked collagen-based material is prepared (e.g., by subjecting it to crosslinking conditions), residual crosslinking agent in the precursor material is quenched. In several embodiments, it has been surprisingly found that, by subjecting the precursor crosslinked collagen based material to a quenching reaction (to provide the crosslinked collagen-based material), improved properties are obtained (e.g., lower toxicity lower cytotoxicity, etc.). In several embodiments, the crosslinked collagen-based material is fabricated into an orthopedic device or used to prepare an orthopedic device (e.g., implant).
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公开(公告)号：US20210338886A1
公开(公告)日：2021-11-04
申请号：US17245782
申请日：2021-04-30
申请人： Harbor MedTech, Inc.
摘要： Disclosed herein are embodiments of a reinforced collagen matrix device for superior capsule repair. The device can include a collagen matrix cover, a first reinforcement strip positioned along the first side of the cover, and a second reinforcement strip positioned along the second side of the cover. A first end and a second end of the first and second reinforcement strips can extend past the first end and the second end of the collagen matrix cover so as not be covered by the collagen matrix cover. The collagen matrix cover can be folded along a first fold and a second fold and extend over the first and second reinforcement strips so that a portion of the first and second reinforcement strips are covered by the collagen matrix cover along a portion of the length of the first reinforcement strip.
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公开(公告)号：US20160102134A1
公开(公告)日：2016-04-14
申请号：US14974750
申请日：2015-12-18
申请人： Harbor MedTech, Inc.
发明人： W. Jerry Mezger , Keith E. Myers
CPC分类号： C07K14/78 , A61K38/16 , A61K38/17 , A61K38/39 , A61L27/24 , A61L27/3687 , A61L27/54 , A61L27/58 , A61L2300/404 , A61L2430/34 , A61L2430/40
摘要： Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
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