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1.发明公开公开(公告)号：US20240261081A1
公开(公告)日：2024-08-08
申请号：US18599990
申请日：2024-03-08
发明人： Shunfu Hu , Linghui Meng , Savario LaFrancesca , Sherif Soliman
IPC分类号： A61F2/04 , A61F2/00 , A61F2/07 , A61F2/82 , A61F2/90 , A61L27/04 , A61L27/18 , A61L27/38 , A61L27/56 , A61L27/58 , C12M1/12 , C12M3/00
CPC分类号： A61F2/04 , A61F2/0077 , A61F2/07 , A61F2/82 , A61L27/04 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L27/58 , C12M21/08 , C12M25/14 , A61F2002/0086 , A61F2002/043 , A61F2002/044 , A61F2002/045 , A61F2002/046 , A61F2/90 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61F2250/0067 , A61L2430/22
摘要： Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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2.发明公开公开(公告)号：US20240216118A1
公开(公告)日：2024-07-04
申请号：US18405658
申请日：2024-01-05
发明人： Ron Sostek , David Green , Linghui Meng , Sherif Soliman , Joseph Consiglio
CPC分类号： A61F2/0063 , A61F2/02 , A61F2/04 , A61F2/07 , A61L27/34 , D01D5/0007 , D01D5/0084 , D04H1/43835 , D04H1/43838 , A61F2002/072 , A61F2210/00 , A61F2210/0071 , A61F2210/0076 , A61F2230/0069 , A61F2230/0091 , A61F2240/001 , A61F2250/0082
摘要： Aspects of the disclosure relate to synthetic tissue or organ scaffolds and methods and compositions for promoting or maintaining their structural integrity. Aspects of the disclosure are useful to prevent scaffold damage (e.g., delamination) during or after implantation into a host. Aspects of the disclosure are useful to stabilize tissue or organ scaffolds that include electrospun fibers.
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公开(公告)号：US20140377863A1
公开(公告)日：2014-12-25
申请号：US14484178
申请日：2014-09-11
IPC分类号： A61L27/36 , A61L27/38 , C12N5/0775
CPC分类号： A61F2/04 , A61F2/02 , A61F2002/046 , A61F2230/006 , A61F2250/0029 , A61L27/18 , A61L27/20 , A61L27/3679 , A61L27/3813 , A61L27/3834 , A61L27/3882 , A61L27/54 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/22 , C12N5/0663 , C12N2502/23 , C12N2533/40 , C08L75/04
摘要： A synthetic scaffold for replacing at least a portion of an airway includes an airway mold, one or more structural ribs on the airway mold, and a non-structural wall. Each of the one or more structural ribs is formed from a first material and the non-structural wall is formed from a second material. The non-structural wall coats the airway mold and forms a conduit that incorporates the one or more structural ribs.
摘要翻译： 用于替换气道的至少一部分的合成支架包括气道模具，气道模具上的一个或多个结构肋和非结构壁。 一个或多个结构肋中的每一个由第一材料形成，并且非结构壁由第二材料形成。 非结构壁涂覆气道模具并形成结合一个或多个结构肋的导管。
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4.发明公开公开(公告)号：US20240033066A1
公开(公告)日：2024-02-01
申请号：US18228828
申请日：2023-08-01
发明人： William Fodor , Linghui Meng
CPC分类号： A61F2/04 , A61L27/18 , A61L27/3834 , A61L27/3882 , A61F2002/044 , A61F2002/045
摘要： Aspects of the disclosure relate methods and synthetic structural supports for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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公开(公告)号：US12048619B2
公开(公告)日：2024-07-30
申请号：US16864620
申请日：2020-05-01
发明人： Saverio La Francesca , Sherif Soliman , Shunfu Hu , Linghui Meng
IPC分类号： A61F2/04 , A61F2/00 , A61F2/07 , A61F2/82 , A61L27/04 , A61L27/18 , A61L27/38 , A61L27/56 , A61L27/58 , C12M1/12 , C12M3/00 , A61F2/90
CPC分类号： A61F2/04 , A61F2/0077 , A61F2/07 , A61F2/82 , A61L27/04 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L27/58 , C12M21/08 , C12M25/14 , A61F2002/0086 , A61F2002/043 , A61F2002/044 , A61F2002/045 , A61F2002/046 , A61F2/90 , A61F2210/0004 , A61F2210/0076 , A61F2230/0069 , A61F2250/0067 , A61L2430/22 , A61L27/18 , C08L75/04 , A61L27/18 , C08L67/02
摘要： Aspects of the disclosure relate methods and synthetic scaffolds for regenerating gastrointestinal tissue (e.g., esophageal tissue).
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公开(公告)号：US20160040107A1
公开(公告)日：2016-02-11
申请号：US14775085
申请日：2014-03-15
发明人： Herbert Hedberg
摘要： Aspects of the disclosure relate to rotating bioreactors and articles and methods that are useful for adapting a rotating bioreactor for use with tissues or scaffolds of different sizes. In some embodiments, bioreactors comprising a reservoir and an arbor assembly are provided herein, in which the arbor assembly comprises a rotatable support to which a tissue or tissue scaffold can be attached.
摘要翻译： 本公开的方面涉及旋转生物反应器和用于使旋转生物反应器适用于不同尺寸的组织或支架的制品和方法。 在一些实施例中，本文提供了包括储存器和心轴组件的生物反应器，其中心轴组件包括可连接组织或组织支架的可旋转支撑件。
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公开(公告)号：US20150011892A1
公开(公告)日：2015-01-08
申请号：US14373215
申请日：2013-01-20
发明人： Ron Sostek
IPC分类号： A61B5/00
摘要： Aspects of the invention relate to methods and devices for evaluating tissue injuries. In some embodiments, the invention provides methods and devices for evaluating tissue injuries based on infrared emission spectra and/or emission levels from injured tissue. In some embodiments, the invention provides methods and devices for evaluating skin injuries (e.g., skin burns) and for targeting treatment delivery to injuries including skin injuries.
摘要翻译： 本发明的方面涉及评估组织损伤的方法和装置。 在一些实施例中，本发明提供了用于基于来自损伤组织的红外发射光谱和/或发射水平来评估组织损伤的方法和装置。 在一些实施方案中，本发明提供了用于评估皮肤损伤（例如皮肤灼伤）和靶向治疗递送至包括皮肤损伤的损伤的方法和装置。
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公开(公告)号：US20160053213A1
公开(公告)日：2016-02-25
申请号：US14780692
申请日：2014-03-27
发明人： Herbert Hedberg
摘要： Aspects of the disclosure relate to bioreactors for maintaining biological objects (e.g., organ or engineered tissues) under culture conditions. In some embodiments, bioreactors and cover assemblies are provided that comprise a support base for supporting a biological object. In some embodiments, bioreactors and cover assemblies are provided that comprise a movable support base configured such that a user can manipulate its position and thus the relative position of the biological object.
摘要翻译： 本公开的方面涉及用于在培养条件下维持生物体（例如器官或工程组织）的生物反应器。 在一些实施例中，提供了生物反应器和盖组件，其包括用于支撑生物体的支撑基座。 在一些实施例中，提供了生物反应器和盖组件，其包括可移动支撑基座，该可移动支撑基座被构造成使得使用者可以操纵其位置并因此操纵生物物体的相对位置。
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