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公开(公告)号：US11299461B2
公开(公告)日：2022-04-12
申请号：US16979503
申请日：2019-03-12
Applicant: HAWAII BIOTECH, INC.
Inventor： Guan-Sheng Jiao , Seong Jin Kim , Alan T. Johnson
IPC: C07D213/54 , C07D213/65 , C07D213/61
Abstract: Compounds of formula I are provided: wherein X is NH, or CH2, Y is a single bond, or —CHR5—, R1 is H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, R2 and R2′ are each independently H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, each R3 is independently H, halo, —CF3, C1-C4 alkyl, or C1-C4 alkoxy, C3 perhaloalkyl, each R4 is independently H, halo, or C1-C4 alkyl, R5 is C1-C4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.
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公开(公告)号：US20190298819A1
公开(公告)日：2019-10-03
申请号：US16315986
申请日：2017-07-07
Applicant: Hawaii Biotech Inc. , Infectious Disease Research Institute
Inventor： David E. Clements , Neal Van Hoeven
Abstract: A West Nile virus (WNV) vaccine for human use is described that contains a recombinantly produced form of truncated WNV envelope glycoprotein and a combination of a Toll-like receptor 4 (TLR-4) and saponin adjuvants. A pharmaceutically acceptable vehicle may also be included in the vaccine.
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公开(公告)号：US11434261B2
公开(公告)日：2022-09-06
申请号：US16320983
申请日：2017-07-26
Applicant: Hawaii Biotech Inc.
Inventor： David E. Clements
Abstract: The present invention is directed to the expression and secretion the Zika virus envelope protein. Elements of the pre-membrane and envelope sequence have been modified to enhance the expression of the envelope protein as a secreted product in the culture medium of transformed insect cell lines. The expressed and purified product is suitable as a vaccine antigen.
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公开(公告)号：US20210371383A1
公开(公告)日：2021-12-02
申请号：US16979503
申请日：2019-03-12
Applicant: HAWAII BIOTECH, INC.
Inventor： Guan-Sheng JIAO , Seong Jin KIM , Alan T. JOHNSON
IPC: C07D213/65 , C07D213/61 , C07D213/54
Abstract: Compounds of formula I are provided: wherein X is NH, or CH2, Y is a single bond, or —CHR5—, R1 is H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, R2 and R2′ are each independently H, C1-C4 alkyl, or C1-C4 hydroxyalkyl, each R3 is independently H, halo, —CF3, C1-C4 alkyl, or C1-C4 alkoxy, C3 perhaloalkyl, each R4 is independently H, halo, or C1-C4 alkyl, R5 is C1-C4 alkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.
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公开(公告)号：US20210332084A1
公开(公告)日：2021-10-28
申请号：US16320983
申请日：2017-07-26
Applicant: Hawaii Biotech Inc.
Inventor： David E. Clements
IPC: C07K14/005 , C12N15/85 , A61K39/12 , A61K39/39 , A61P31/14
Abstract: The present invention is directed to the expression and secretion the Zika virus envelope protein. Elements of the pre-membrane and envelope sequence have been modified to enhance the expression of the envelope protein as a secreted product in the culture medium of transformed insect cell lines. The expressed and purified product is suitable as a vaccine antigen.
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Patent Agency Ranking
公开(公告)号：US20200289636A1
公开(公告)日：2020-09-17
申请号：US16645417
申请日：2018-09-06
Applicant: Hawaii Biotech, Inc.
Inventor： David E. CLEMENTS , Michael M. LIEBERMAN , Axel T. LEHRER
IPC: A61K39/12 , A61P31/14 , A61K39/295
Abstract: The data reported herein describe the production and evaluation of a recombinant subunit filovirus vaccine using insect cell expressed surface glycoprotein (GP) and a highly effective adjuvant. The vaccine provides protection in humans against filovirus infection, including Ebola virus and Marburg virus.
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公开(公告)号：US10039820B2
公开(公告)日：2018-08-07
申请号：US15331596
申请日：2016-10-21
Applicant: HAWAII BIOTECH, INC.
Inventor： Beth-Ann Coller , Vidya Pai , Carolyn L. Weeks-Levy , Steven A. Ogata
Abstract: A West Nile virus vaccine for human use is described that preferably contains a recombinantly produced form of truncated West Nile virus envelope glycoprotein and aluminum adjuvant. The vaccine is acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. The vaccine is safe and effective for use in all healthy and at-risk populations. A pharmaceutically acceptable vehicle may also be included in the vaccine.
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公开(公告)号：US09688618B2
公开(公告)日：2017-06-27
申请号：US15280817
申请日：2016-09-29
Applicant: HAWAII BIOTECH, INC.
Inventor： Alan Thomas Johnson , Seong Jin Kim , Sean O'Malley , Henry Lee Jackson
IPC: C07C259/06 , C07D213/56 , C07D295/16 , C07D207/337 , C07C259/10 , C07D239/26 , C07D239/42 , C07D231/12 , C07D295/205 , C07D295/155 , C07D303/46
CPC classification number: C07C259/06 , C07C259/10 , C07C2601/02 , C07D207/337 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D295/155 , C07D295/16 , C07D295/185 , C07D295/205 , C07D303/46
Abstract: Compounds of formula I are provided: R1 is an alkoxy or O(CH2)pX, p is an integer from 2 to 3 and X is OH, NH2, or CO2H, m is an integer from 0 to 5, n is an integer from 0 to 5, each R2 is independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each R3 is independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of R2 and R3 is not hydrogen.
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公开(公告)号：US20170165349A1
公开(公告)日：2017-06-15
申请号：US15331596
申请日：2016-10-21
Applicant: HAWAII BIOTECH, INC.
Inventor： Beth-Ann Coller , Vidya Pai , Carolyn L. Weeks-Levy , Steven A. Ogata
IPC: A61K39/12
CPC classification number: A61K39/12 , A61K2039/545 , A61K2039/55505 , C12N2770/24134 , C12N2770/24171 , Y02A50/394
Abstract: A West Nile virus vaccine for human use is described that preferably contains a recombinantly produced form of truncated West Nile virus envelope glycoprotein and aluminum adjuvant. The vaccine is acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. The vaccine is safe and effective for use in all healthy and at-risk populations. A pharmaceutically acceptable vehicle may also be included in the vaccine.
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公开(公告)号：US11135281B2
公开(公告)日：2021-10-05
申请号：US16315986
申请日：2017-07-07
Applicant: Hawaii Biotech Inc. , Infectious Disease Research Institute
Inventor： David E. Clements , Neal Van Hoeven
Abstract: A West Nile virus (WNV) vaccine for human use is described that contains a recombinantly produced form of truncated WNV envelope glycoprotein and a combination of a Toll-like receptor 4 (TLR-4) and saponin adjuvants. A pharmaceutically acceptable vehicle may also be included in the vaccine.
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