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公开(公告)号：US08987209B2
公开(公告)日：2015-03-24
申请号：US13876777
申请日：2011-09-26
申请人： Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Stelte-Ludwig , Sven Golfier , Joachim Schuhmacher , Jean Mark Gnoth , Ursula Krenz
发明人： Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Stelte-Ludwig , Sven Golfier , Joachim Schuhmacher , Jean Mark Gnoth , Ursula Krenz
CPC分类号： C07K5/1021 , A61K38/00 , A61K38/07 , A61K38/08 , A61K45/06 , C07K1/1077 , C07K5/0205 , C07K7/02
摘要： The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
摘要翻译： 本申请涉及通过羧基烷基在N末端被取代的单甲基海洛定蛋白F的新衍生物，用于制备这些衍生物的方法，其用于治疗和/或预防疾病以及产生用于治疗和/或预防 疾病，特别是过度增生和/或血管发生疾病，例如癌症。 这种治疗可以作为单一疗法发生，或与其他药物或其他治疗措施组合发生。
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公开(公告)号：US20130122024A1
公开(公告)日：2013-05-16
申请号：US13451916
申请日：2012-04-20
申请人： Hans-Georg LERCHEN , Beatrix STELTE-LUDWIG , Sven GOLFIER , Charlotte Christine KOPITZ , Rudolf BEIER , Sherif EL SHEIKH , Iring HEISLER , Axel HARRENGA , Karl-Heinz THIERAUCH , Joachim SCHUHMACHER , Sandra BRUDER , Simone GREVEN , Lars LINDEN , Jörg WILLUDA , Christoph MAHLERT , Heike PETRUL , Hannah JÖRIßEN , Sandra Borkowski
发明人： Hans-Georg LERCHEN , Beatrix STELTE-LUDWIG , Sven GOLFIER , Charlotte Christine KOPITZ , Rudolf BEIER , Sherif EL SHEIKH , Iring HEISLER , Axel HARRENGA , Karl-Heinz THIERAUCH , Joachim SCHUHMACHER , Sandra BRUDER , Simone GREVEN , Lars LINDEN , Jörg WILLUDA , Christoph MAHLERT , Heike PETRUL , Hannah JÖRIßEN , Sandra Borkowski
IPC分类号： C07K16/18 , A61K39/395 , A61K45/06 , C07K7/06
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及针对靶间皮素的N，N-二烷基海马素的新粘合剂 - 药物偶联物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，以及使用这些ADC用于治疗和 /或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US08722629B2
公开(公告)日：2014-05-13
申请号：US13702881
申请日：2011-06-06
CPC分类号： C07K7/02 , A61K38/00 , A61K38/08 , A61K45/06 , C07K5/0205
摘要： The present application relates to novel derivatives of monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and also to the use of these derivatives for preparing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as, for example, cancerous disorders. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及单甲基黄加里他汀F的新衍生物，制备这些衍生物的方法，这些衍生物用于治疗和/或预防疾病的用途，以及这些衍生物用于制备用于治疗和/或预防疾病的药物的用途 ，更特别是过度增殖和/或血管生成障碍，例如癌性疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US20140127240A1
公开(公告)日：2014-05-08
申请号：US14113070
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.
摘要翻译： 本专利申请涉及针对靶表皮生长因子受体（EGFR，基因ID 1956）的N，N-二烷基硫酸锡的新型粘合剂 - 药物共轭物（ADC），这些ADC的有效代谢物，制备这些ADC的方法， 这些ADC用于治疗和/或预防疾病，以及使用这些ADC来制备用于治疗和/或预防疾病，特别是过度增生和/或血管发生疾病例如癌症的药物。 这样的治疗可以作为单一疗法或与其它药物或其他治疗措施组合施用。
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公开(公告)号：US20130261064A1
公开(公告)日：2013-10-03
申请号：US13876777
申请日：2011-09-26
申请人： Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Srelte Ludwig , Sven Golfier , Joachim Schumacher , Joan Mark Gnoth , Ursula Krenz
发明人： Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Srelte Ludwig , Sven Golfier , Joachim Schumacher , Joan Mark Gnoth , Ursula Krenz
CPC分类号： C07K5/1021 , A61K38/00 , A61K38/07 , A61K38/08 , A61K45/06 , C07K1/1077 , C07K5/0205 , C07K7/02
摘要： The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
摘要翻译： 本申请涉及通过羧基烷基在N末端被取代的单甲基海洛定蛋白F的新衍生物，用于制备这些衍生物的方法，其用于治疗和/或预防疾病以及产生用于治疗和/或预防 疾病，特别是过度增生和/或血管发生疾病，例如癌症。 这种治疗可以作为单一疗法发生，或与其他药物或其他治疗措施组合发生。
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公开(公告)号：US20130157960A1
公开(公告)日：2013-06-20
申请号：US13702881
申请日：2011-06-06
CPC分类号： C07K7/02 , A61K38/00 , A61K38/08 , A61K45/06 , C07K5/0205
摘要： The present application relates to novel derivatives of monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and also to the use of these derivatives for preparing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as, for example, cancerous disorders. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及单甲基黄加里他汀F的新衍生物，制备这些衍生物的方法，这些衍生物用于治疗和/或预防疾病的用途，以及这些衍生物用于制备用于治疗和/或预防疾病的药物的用途 ，更特别是过度增殖和/或血管生成障碍，例如癌性疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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公开(公告)号：US20130066055A1
公开(公告)日：2013-03-14
申请号：US13451950
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
IPC分类号： C07K17/02
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译： 本申请涉及针对目标C4.4a的N，N-二烷基硫酸钠的新粘合剂 - 药物共轭物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，使用这些ADC 治疗和/或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。 这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。
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8.发明申请USE OF HIGH-DOSES OF MONOMERIC CONTRAST MEDIUM CONTAINING IODINE IN X-RAY DIAGNOSTICS, IN PARTICULAR IN INTERVENTIONAL X-RAY DIAGNOSTICS AND IN RADIATION THERAPY ASSISTED BY CONTRAST MEDIA CONTAINING IODINE 审中-公开在X射线诊断中使用高剂量的含有碘的单因素对照药物，特别是传统的X射线诊断和放射治疗由对称物质含有的碘公开(公告)号：US20120134933A1
公开(公告)日：2012-05-31
申请号：US13319373
申请日：2010-05-06
IPC分类号： A61K49/04 , A61K31/167 , A61P13/12 , C07C237/46
CPC分类号： A61K49/0433 , A61K49/0438
摘要： The invention relates to a diagnostic or therapeutic composition comprising a monomeric X-ray contrast medium containing iodine, in particular iopromide, for use in an X-ray assisted diagnosis or therapy and for the use of high doses of an X-ray contrast medium given to a patient, in particular patients with restricted kidney function.
摘要翻译： 本发明涉及一种诊断或治疗组合物，其包含含有碘的单体X射线造影剂，特别是碘普罗胺，用于X射线辅助诊断或治疗，以及使用高剂量的X射线造影剂 特别是患有肾功能受限的患者。
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