公开(公告)号：US07220733B2

公开(公告)日：2007-05-22

申请号：US10400936

申请日：2003-03-28

申请人： Heinz-Helmer Rasche ,  Kirsten Wilbrand ,  Kerstin Woltmann

发明人： Heinz-Helmer Rasche ,  Kirsten Wilbrand ,  Kerstin Woltmann

IPC分类号： A61K31/56

CPC分类号： C07J1/0059 ,  C07J1/007 ,  Y10T436/203332

摘要： A method of separating cresol from mares' urine by pervaporation using pore-free polymeric silicone membranes in which starting urine solutions containing high-quality and -quantity conjugated estrogens with a reduced or substantially removed cresol content are provided which are advantageously suitable for obtaining natural mixtures of conjugated estrogens from pregnant mares' urine.

摘要翻译： 提供了使用无孔聚合物硅氧烷膜通过渗透蒸发从甲苯尿中分离甲酚的方法，其中含有具有降低或基本上除去的甲酚含量的高质量和量子结合的雌激素的起始尿液溶液有利地适合于获得天然混合物 的结合雌激素从怀孕母猪的尿。

公开(公告)号：US5723454A

公开(公告)日：1998-03-03

申请号：US753508

申请日：1996-11-26

申请人： Ivan Ban ,  Henning Heinemann ,  Gerhard Mechtold ,  Heinz-Helmer Rasche

发明人： Ivan Ban ,  Henning Heinemann ,  Gerhard Mechtold ,  Heinz-Helmer Rasche

IPC分类号： C07J20060101 ,  C07J1/00 ,  A61K31/56

CPC分类号： C07J1/0051

摘要： A method for obtaining an extract containing the natural mixture of conjugated estrogens from mare urine by solid-phase extraction of the mixture of conjugated estrogens from the urine of pregnant mares on non-ionic semi-polar polymeric adsorber resins.

摘要翻译： 一种通过在非离子半极性聚合物吸附树脂上从怀孕母马的尿液中固相萃取共轭雌激素混合物来获得含有母马共轭雌激素的天然混合物的提取物的方法。

公开(公告)号：US20070212751A1

公开(公告)日：2007-09-13

申请号：US11653376

申请日：2007-01-16

申请人： Josef Messinger ,  Heinrich-Hubert Thole ,  Heinz-Helmer Rasche ,  Michael Schmidt ,  Juha Hakala

发明人： Josef Messinger ,  Heinrich-Hubert Thole ,  Heinz-Helmer Rasche ,  Michael Schmidt ,  Juha Hakala

IPC分类号： C12P33/08 ,  C12N1/20

CPC分类号： C12P33/08 ,  C07J5/00

摘要： Use of bacterial strains of the species Amycolatopsis mediterranei for microbial transformation of 9β,10α-steroids of formula (I) to their corresponding 11β-hydroxyl analogues, as well as specific strains of that species, a process for transforming 9β,10α-steroids to their corresponding 11β-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and subsequent isolation of the 11β-hydroxyl derivatives from the bacterial culture medium. The resulting 11β-hydroxylated products are useful intermediates for preparing novel steroidal compounds with 9β,10α-confirmation carrying different kinds of substituents in the 11β-position.

摘要翻译： 使用物种Amycolatopsis mediterranei的细菌菌株将式（I）的9beta，10α-类固醇微生物转化成其相应的11b-羟基类似物，以及该物种的特异性菌株，将9beta，10α-类固醇转化为 它们相应的11beta-羟基衍生物，使用物种Amycolatopsis mediterranei的细菌菌株，随后从细菌培养基中分离出11β-羟基衍生物。 所得的11b-羟基化产物是制备具有9beta，10α-确认的新型甾体化合物的有用中间体，其在11beta位置携带不同种类的取代基。

公开(公告)号：US5814624A

公开(公告)日：1998-09-29

申请号：US933089

申请日：1997-09-18

申请人： Ivan Ban ,  Friederich Borchers ,  Henning Heinemann ,  Heinz-Helmer Rasche

发明人： Ivan Ban ,  Friederich Borchers ,  Henning Heinemann ,  Heinz-Helmer Rasche

IPC分类号： C07J20060101 ,  C07J1/00 ,  A61K35/22

CPC分类号： C07J1/0051

摘要： A method for obtaining an extract from urine of pregnant mares containing a natural mixture of conjugated estrogens by solid-phase extraction of the mixture of conjugated estrogens from the urine of pregnant mares on RP silica gel.

摘要翻译： 一种通过在RP硅胶上从怀孕母马的尿中固相萃取共轭雌激素混合物获得含有共轭雌激素天然混合物的怀孕母马尿液提取物的方法。

公开(公告)号：US20060234994A1

公开(公告)日：2006-10-19

申请号：US11451472

申请日：2006-06-13

申请人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

发明人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

IPC分类号： A61K31/56 ,  C07J1/00

CPC分类号： C07J1/00 ,  C07J75/00

摘要： A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorbent cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.

摘要翻译： 用于从固体吸附剂载体上浓缩和稳定来自怀孕母马的结合雌激素的方法和装置，以获得在马附近的药筒上含有共轭雌激素混合物的天然混合物的药物起始材料。 吸收剂盒可以装载在尿液收集部位，因此不需要将大量的尿液运送到中央处理点。 加载过程可以持续几周，直到色谱柱饱和。 流出的尿液保留在可处置设施的场所。 只有装载的墨盒才能运输，运输可能会在更长的间隔内进行，最长可达数周。 共轭雌激素对吸附剂的稳定性确保没有分解的危险。

公开(公告)号：US07081451B2

公开(公告)日：2006-07-25

申请号：US10112040

申请日：2002-04-01

申请人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

发明人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

IPC分类号： A61K31/56

CPC分类号： C07J1/00 ,  C07J75/00

摘要： A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.

公开(公告)号：US06300468B1

公开(公告)日：2001-10-09

申请号：US09230522

申请日：1999-09-23

申请人： Karl-Heinz Bretz ,  Heinz-Helmer Rasche ,  Helmut Derleth ,  Philippe Francois

发明人： Karl-Heinz Bretz ,  Heinz-Helmer Rasche ,  Helmut Derleth ,  Philippe Francois

IPC分类号： C08F600

CPC分类号： B01J35/08 ,  B01J20/26 ,  B01J31/06 ,  B01J31/26 ,  C08J3/14 ,  C08J9/28 ,  C08J2201/052 ,  C08L23/06 ,  C08L23/12 ,  C08L27/06 ,  Y02P20/52 ,  C08L2666/04

摘要： A process for producing porous polymer beads in which polymers, preferably polyolefins or polyvinyl chloride, are dissolved in a solvent, preferably halogenated hydrocarbons or alkyl esters, at temperatures close to the boiling point of the solvent. The hot polymer solution is cooled, and the polymer beads formed during the cooling process are separated, washed and dried. The porous polymer beads are useful, for example, as catalyst carriers or as adsorption agents.

摘要翻译： 一种生产多孔聚合物珠粒的方法，其中聚合物，优选聚烯烃或聚氯乙烯在接近溶剂沸点的温度下溶解在溶剂中，优选卤代烃或烷基酯。 将热聚合物溶液冷却，分离冷却过程中形成的聚合物珠粒，洗涤和干燥。 多孔聚合物珠粒可用作例如催化剂载体或吸附剂。

公开(公告)号：US07524833B2

公开(公告)日：2009-04-28

申请号：US11451472

申请日：2006-06-13

申请人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

发明人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

IPC分类号： A61K31/56

CPC分类号： C07J1/00 ,  C07J75/00

摘要： A method and apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorbent cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.

摘要翻译： 用于从固体吸附剂载体上浓缩和稳定来自怀孕母马的结合雌激素的方法和装置，以获得在马附近的药筒上含有共轭雌激素混合物的天然混合物的药物起始材料。 吸收剂盒可以装载在尿液收集部位，因此不需要将大量的尿液运送到中央处理点。 加载过程可以持续几周，直到色谱柱饱和。 流出的尿液保留在可处置设施的场所。 只有装载的墨盒才能运输，运输可能会在更长的间隔内进行，最长可达数周。 共轭雌激素对吸附剂的稳定性确保没有分解的危险。

公开(公告)号：US07964586B2

公开(公告)日：2011-06-21

申请号：US10890390

申请日：2004-07-14

申请人： Heinz-Helmer Rasche ,  Kirsten Wilbrand ,  Sabine Banschbach

发明人： Heinz-Helmer Rasche ,  Kirsten Wilbrand ,  Sabine Banschbach

IPC分类号： A61K31/56

CPC分类号： C07J75/00

摘要： A method for obtaining an extract containing the natural mixture of conjugated equine estrogens in which a mixture of conjugated estrogens obtained by solid-phase extraction from pregnant mares' urine is depleted in phenolic urine contents and in non-conjugated lipophilic compounds selected from the group consisting of non-conjugated flavonoids, non-conjugated isoflavonoids, non-conjugated norisoprenoids, non-conjugated steroids, in particular androstane and pregnane steroids, and comparable non-conjugated compounds.

摘要翻译： 一种获得含有共轭马雌激素的天然混合物的提取物的方法，其中通过从怀孕母马的尿液中固相提取而获得的共轭雌激素的混合物在酚尿含量中消耗，而在非共轭亲脂化合物中， 非共轭类异黄酮，非共轭类异戊二烯，非共轭类固醇，特别是雄甾烷和孕甾类固醇，以及可比非共轭化合物。

公开(公告)号：US07074325B2

公开(公告)日：2006-07-11

申请号：US11141390

申请日：2005-06-01

申请人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

发明人： Juergen Ahnsorge ,  Ivan Ban ,  Heinz-Helmer Rasche

IPC分类号： B01D15/08

CPC分类号： C07J1/00 ,  C07J75/00

摘要： An apparatus for concentrating and stabilizing conjugated estrogens from pregnant mare urine on solid adsorbent supports to obtain a starting material for pharmaceuticals that contain a natural mixture of conjugated estrogens as active ingredient. The apparatus is suitable for decentralized concentration and stabilization of conjugated estrogen mixtures on cartridges in the vicinity of the horses. The adsorber cartridges can be loaded at the site of urine collection so it is unnecessary to transport large volumes of urine to a central processing point. The loading process can take continuously over a period of weeks until the column is saturated. The effluent urine remains at the site where facilities for its disposal are available. Only the loaded cartridge is transported, and transport can occur at longer intervals of up to several weeks. The stability of the conjugated estrogens on the adsorber assures there is no risk of decomposition.

摘要翻译： 用于在固体吸附剂载体上浓缩和稳定来自怀孕母马的结合雌激素的装置，以获得含有共轭雌激素作为活性成分的天然混合物的药物的起始材料。 该装置适用于在马附近的药筒上分散浓缩和稳定缀合的雌激素混合物。 吸收器筒可以装载在尿液收集部位，因此不需要将大量的尿液输送到中央处理点。 加载过程可以持续几周，直到色谱柱饱和。 流出的尿液保留在可处置设施的场所。 只有装载的墨盒才能运输，运输可能会在更长的间隔内进行，最长可达数周。 共轭雌激素对吸附剂的稳定性确保没有分解的危险。