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公开(公告)号：US20090326014A1
公开(公告)日：2009-12-31
申请号：US12308923
申请日：2007-06-29
IPC分类号： A61K31/4418 , A61K31/415
CPC分类号： A61K31/00 , A61K31/415 , A61K31/4418
摘要： The present invention refers to the use of 5-HT7 receptor agonists for the treatment of pain and the symptoms of pain, especially certain subtypes of pain like neuropathic pain and inflammatory pain and symptoms involving allodynia and hyperalgesia, the prevention or the prophylaxis of pain and the symptoms of pain, especially certain subtypes of pain like neuropathic pain and inflammatory pain and symptoms involving allodynia and hyperalgesia.
摘要翻译： 本发明涉及5-HT7受体激动剂用于治疗疼痛和疼痛症状，特别是疼痛的某些亚型，如神经性疼痛和炎性疼痛以及涉及异常性疼痛和痛觉过敏的症状，预防或预防疼痛和 疼痛的症状，特别是某些亚型的疼痛，如神经性疼痛和炎性疼痛以及涉及异常性疼痛和痛觉过敏的症状。
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2.发明申请Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments 审中-公开杂环取代的 - 乙基氨基 - 苯基衍生物，它们的制备和用作药物公开(公告)号：US20100152252A1
公开(公告)日：2010-06-17
申请号：US12520463
申请日：2007-12-21
IPC分类号： A61K31/415 , C07D231/12 , C07C211/27 , C07C217/56 , C07D261/08 , C07D213/64 , A61K31/137 , A61K31/42 , A61K31/4418 , A61P25/00 , A61P25/06 , A61P25/22 , A61P9/12 , A61P1/00 , A61P29/00 , A61P13/00
CPC分类号： C07D231/12 , C07C211/27 , C07C211/29 , C07C217/60 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-ethylamino-phenyl compounds of general formula (I), wherein K-L-M-N, Z and R1, R2, R3, R4 are as described in the claims methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基取代的 - 乙基氨基 - 苯基化合物，其中KLMN，Z和R1，R2，R3，R4如权利要求的制备方法所述，包含这些化合物的药物以及 它们用于制备用于治疗人或动物的药物的用途。
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公开(公告)号：US20090264457A1
公开(公告)日：2009-10-22
申请号：US12221364
申请日：2008-08-01
IPC分类号： A61K31/437 , A61K31/404 , A61K31/426 , A61K31/416 , A61K31/454 , A61P25/00 , A61P25/28
CPC分类号： A61K31/192 , A61K31/4045 , A61K31/4155 , A61K31/428 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/63
摘要： The present invention relates to a Combination of at least two 5HT6-Ligands of which one is a partial or agonist while the other is a full antagonist or an inverse agonist, a medicament comprising this comination, the use of the combiantion in the manufacture of a medicament for the treatment of memory disorders ADHD, and methods of treatment using the combination or its members.
摘要翻译： 本发明涉及至少两种5HT6配体的组合，其中一种是部分或激动剂，另一种是完全拮抗剂或反向激动剂，包含该配体的药物，组合物在制备中的用途 用于治疗记忆障碍ADHD的药物，以及使用该组合或其成员的治疗方法。
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4.发明申请Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome 审中-公开使用与Sigma受体结合用于治疗代谢综合征的化合物公开(公告)号：US20090181976A1
公开(公告)日：2009-07-16
申请号：US12224254
申请日：2007-02-28
IPC分类号： A61K31/495 , A61P3/10
CPC分类号： A61K31/00
摘要： The present invention refers to the use of compounds binding to the sigma receptor for the treatment of metabolic syndrome.
摘要翻译： 本发明涉及结合σ受体的化合物用于治疗代谢综合征的用途。
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5.发明授权Heterocyclyl substituted tetrahydronaphthalene derivatives as 5-HT7 receptor ligands 失效杂环取代的四氢萘衍生物作为5-HT7受体配体公开(公告)号：US08097641B2
公开(公告)日：2012-01-17
申请号：US12525461
申请日：2008-02-06
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07D213/64 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。
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6.发明申请SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS 失效磺酰胺取代的吡咯啉化合物，其制备和用作CB1调节剂公开(公告)号：US20100184772A1
公开(公告)日：2010-07-22
申请号：US12445260
申请日：2007-10-10
IPC分类号： C07D231/06 , A61K31/415 , A61K31/4178 , C07D403/12 , C07D409/12 , A61K31/4155 , A61K31/428 , C07D417/12 , C07D405/12 , C07D413/12 , A61K31/422 , A61K31/513 , C07D401/12 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/433 , A61K31/427 , A61K31/4725 , A61K31/498 , C07D513/04 , A61K31/429 , A61P5/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P37/00 , A61P15/00 , A61P1/00 , A61P35/00 , A61P19/00 , A61P3/00
CPC分类号： C07D231/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代吡唑啉化合物，其制备方法，包含这些化合物的药物及其制备用于治疗人和动物的药物的用途。
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7.发明授权Heterocyclyl-substituted-tetrahydro-naphthalen-amine derivatives, their preparation and use as medicaments 失效杂环取代 - 四氢 - 萘胺衍生物，其制备和用途作为药物公开(公告)号：US08236845B2
公开(公告)日：2012-08-07
申请号：US12593464
申请日：2008-03-28
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07D213/38 , C07D261/08 , C07D307/52 , C07D333/20
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘胺化合物及其组合物，其制备方法以及所述化合物用于治疗或预防人或动物各种疾病的用途。
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公开(公告)号：US07345057B2
公开(公告)日：2008-03-18
申请号：US11048992
申请日：2005-02-02
申请人： Antoni Torrens Jover , Susana Yenes Minguez , Jose Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Susana Yenes Minguez , Jose Mas Prio , Luz Romero Alonso , Alberto Dordal Zueras , Helmut H. Buschmann
IPC分类号： C07D401/02 , A61K31/4709
CPC分类号： C07B57/00 , C07B2200/07 , C07B2200/11 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地涉及一些四氢异喹啉取代的磺酰胺化合物，制备这些化合物的方法，包含它们的药物组合物及其用于治疗和/或预防 的5-HT涉及的疾病，如CNS疾病。
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公开(公告)号：US07211585B2
公开(公告)日：2007-05-01
申请号：US10920738
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D217/04 , C07D401/12
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，更具体地说涉及一些四氢异喹啉取代的磺酰胺化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/ 涉及5-HT的疾病，如CNS疾病。
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公开(公告)号：US07211584B2
公开(公告)日：2007-05-01
申请号：US10920671
申请日：2004-08-18
申请人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
发明人： Antoni Torrens Jover , Josep Mas Prio , Susana Yenes Minguez , Monica Garcia Lopez , Alberto Dordal Zueras , Luz Romero Alonso , Helmut H. Buschmann
IPC分类号： C07D217/00 , A61K31/47
CPC分类号： C07D401/12 , C07D217/04
摘要： The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline propyl sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT 7受体具有药理活性的化合物，更具体地说，涉及一些四氢异喹啉丙磺酰胺化合物，其制备方法，包含它们的药物组合物及其用于治疗和/或预防 涉及5-HT的疾病，如CNS疾病。
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