公开(公告)号：US10270220B1

公开(公告)日：2019-04-23

申请号：US14206607

申请日：2014-03-12

Applicant: Henry M. Eppich ,  Jonah H. Jacob

Inventor： Henry M. Eppich ,  Jonah H. Jacob

IPC: H01S5/024

Abstract: Methods and systems for increased heat removal from devices in which the component design allows for thinner heat removal components.

公开(公告)号：US09001855B1

公开(公告)日：2015-04-07

申请号：US13912839

申请日：2013-06-07

Applicant: Jonah H. Jacob ,  Henry M. Eppich ,  Geoffrey O. Campbell ,  Wenyang Sun

Inventor： Jonah H. Jacob ,  Henry M. Eppich ,  Geoffrey O. Campbell ,  Wenyang Sun

IPC: H01S3/04 ,  H01S5/024

CPC classification number: H01S5/4025 ,  H01S5/0014 ,  H01S5/02423 ,  H01S5/02484

Abstract: A method, and systems to implement the method, for reducing slow axis divergence in a laser diode bar including tailoring a power deposition profile across the emitter so as to reduce thermal gradients, thereby resulting in a substantially (nearly) uniform temperature across the width of the emitter.

Abstract translation: 一种用于实现该方法的方法和系统，用于减少激光二极管条中的慢轴发散，包括跨越发射极定制功率沉积分布，从而降低热梯度，从而导致跨越宽度的 发射器。

公开(公告)号：US10775116B1

公开(公告)日：2020-09-15

申请号：US16059634

申请日：2018-08-09

Applicant: Jonah H. Jacob ,  Henry M. Eppich

Inventor： Jonah H. Jacob ,  Henry M. Eppich

IPC: F28F19/00 ,  F28F3/08

Abstract: Methods to minimize electro-corrosion in the water cooling ports of stacked heat sinks (coolers) and components fabricated according to those methods are disclosed.

公开(公告)号：US10107573B1

公开(公告)日：2018-10-23

申请号：US14593576

申请日：2015-01-09

Applicant: Jonah H. Jacob ,  Henry M. Eppich

Inventor： Jonah H. Jacob ,  Henry M. Eppich

IPC: F28F3/00 ,  F28F19/00 ,  F28F3/08

Abstract: Methods to minimize electro-corrosion in the water cooling ports of stacked heat sinks (coolers) and components fabricated according to those methods are disclosed.

公开(公告)号：US06589786B1

公开(公告)日：2003-07-08

申请号：US09489116

申请日：2000-01-21

Applicant: Joseph A. Mangano ,  Henry M. Eppich

Inventor： Joseph A. Mangano ,  Henry M. Eppich

IPC: C12N508

CPC classification number: C12N5/0087 ,  C12M35/02 ,  C12M47/04 ,  C12N1/02 ,  C12N1/06 ,  C12N5/0093 ,  C12N13/00

Abstract: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage. The invention enables effective cell separation without the need to employ undesirable exogenous agents, such as toxins or antibodies. The inventive method also enables relatively rapid cell separation involving a relatively low degree of trauma or modification to the selected, desired cells. The inventive method has a variety of potential applications in clinical medicine, research, etc., with two of the more important foreseeable applications being stem cell enrichment/isolation, and cancer cell purging.

公开(公告)号：US6043066A

公开(公告)日：2000-03-28

申请号：US148620

申请日：1998-09-04

Applicant: Joseph A. Mangano ,  Henry M. Eppich

Inventor： Joseph A. Mangano ,  Henry M. Eppich

IPC: C12M3/00 ,  C12N1/02 ,  C12N1/06 ,  C12N5/00 ,  C12N5/06 ,  C12N5/08 ,  C12N13/00

CPC classification number: C12N5/0087 ,  C12M35/02 ,  C12M47/04 ,  C12N1/02 ,  C12N1/06 ,  C12N13/00 ,  C12N5/0093

Abstract: The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold; which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage. The invention enables effective cell separation without the need to employ undesirable exogenous agents, such as toxins or antibodies. The inventive method also enables relatively rapid cell separation involving a relatively low degree of trauma or modification to the selected, desired cells. The inventive method has a variety of potential applications in clinical medicine, research, etc., with two of the more important foreseeable applications being stem cell enrichment/isolation, and cancer cell purging.

Abstract translation: 本发明涉及能够使具有导电内芯的离散物体的方法和装置，其被介电膜包围，以通过其电场通过其介电膜的不可逆击穿来选择性地失活。 本发明的一个重要应用是从细胞悬浮液中选择，纯化和/或清除所需或不需要的生物细胞。 根据本发明，可以使用电场来选择性地使悬浮液中的非活细胞细胞群失活并使其呈现，同时不影响其它所需亚种群。 根据本发明的方法，可以基于特征电穿孔阈值的固有或诱导差异来选择细胞; 这可以取决于例如电池尺寸和/或临界电介质膜击穿电压的差异。 本发明能够有效地进行细胞分离，而不需要使用不需要的外源性试剂，例如毒素或抗体。 本发明的方法还使得相对快速的细胞分离涉及对所选择的所需细胞的相对低的创伤或修饰程度。 本发明方法在临床医学，研究等方面具有多种潜在的应用，其中两个更重要的可预见的应用是干细胞富集/分离和癌细胞清除。