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公开(公告)号：US07064121B2
公开(公告)日：2006-06-20
申请号：US10962598
申请日：2004-10-13
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61P19/00 , A61K31/55 , C07D267/14 , C07D267/16 , C07D281/10
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals
摘要翻译： 结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性
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公开(公告)号：US20050059699A1
公开(公告)日：2005-03-17
申请号：US10962598
申请日：2004-10-13
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： C07D243/12 , A61K31/395 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/535 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5517 , A61K31/553 , A61K31/554 , A61K38/00 , A61P5/06 , A61P17/02 , A61P19/00 , A61P19/08 , A61P19/10 , A61P37/00 , A61P43/00 , C07D209/38 , C07D209/42 , C07D215/06 , C07D215/22 , C07D223/16 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/24 , C07D265/36 , C07D267/14 , C07D267/20 , C07D279/16 , C07D281/10 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07K5/06 , C07D211/60 , A61K31/401 , A61K31/445
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译： 结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性。
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公开(公告)号：US20080027038A1
公开(公告)日：2008-01-31
申请号：US11892063
申请日：2007-08-20
申请人： HIdenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okumo , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： HIdenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okumo , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61P17/02 , A61P19/10 , A61P5/00 , C07D243/10 , C07D267/14 , C07D281/10 , C07D403/12 , C07D417/12
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译： 结构式（I）的化合物，其中A是包含脂族桥基的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性。
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公开(公告)号：US07279573B2
公开(公告)日：2007-10-09
申请号：US11359616
申请日：2006-02-23
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61P5/00 , A61K31/55 , C07D267/00
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals
摘要翻译： 结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性
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公开(公告)号：US06864250B1
公开(公告)日：2005-03-08
申请号：US09485845
申请日：1998-08-20
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： C07D243/12 , A61K31/395 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/535 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5517 , A61K31/553 , A61K31/554 , A61K38/00 , A61P5/06 , A61P17/02 , A61P19/00 , A61P19/08 , A61P19/10 , A61P37/00 , A61P43/00 , C07D209/38 , C07D209/42 , C07D215/06 , C07D215/22 , C07D223/16 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/24 , C07D265/36 , C07D267/14 , C07D267/20 , C07D279/16 , C07D281/10 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07K5/06 , C07D267/02 , C07D281/02
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals
摘要翻译： 结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性
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公开(公告)号：US20060142264A1
公开(公告)日：2006-06-29
申请号：US11359616
申请日：2006-02-23
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61K31/554 , A61K31/553
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译： 结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的 其盐和单独的异构体，其在人或动物中具有生长激素释放活性。
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