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10 条记录 (耗时 0.028 秒)

    Novel amide derivatives as growth hormone secretagogues
    7.
    发明申请
    Novel amide derivatives as growth hormone secretagogues 审中-公开
    新型酰胺衍生物作为生长激素促分泌素

    公开(公告)号：US20060014701A1

    公开(公告)日：2006-01-19

    申请号：US11218562

    申请日：2005-09-06

    申请人： Nobuo Ishiyama ,  Hirohide Ishige ,  Mitsuo Mimura ,  Tadashi Okuno ,  Kiyoharu Ukai ,  Takeshi Kiyofuji ,  Shinji Tauchi ,  Kiyoshi Inoguchi ,  Ping Huang ,  Gilda Loew ,  Linda Maki

    发明人： Nobuo Ishiyama ,  Hirohide Ishige ,  Mitsuo Mimura ,  Tadashi Okuno ,  Kiyoharu Ukai ,  Takeshi Kiyofuji ,  Shinji Tauchi ,  Kiyoshi Inoguchi ,  Ping Huang ,  Gilda Loew ,  Linda Maki

    IPC分类号： A61K38/04 ,  C07K5/04

    CPC分类号： C07K5/06165 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0205 ,  C07K5/06026 ,  C07K5/06034 ,  C07K5/06078 ,  C07K5/06139

    摘要： Disclosed are the novel compounds as growth hormone secretagogues represented by the structural Formula I: wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is —CO— or —SO2—, Y is: wherein n is an integer from 0-4, R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, R5 and R6 are independently selected from hydrogen, substituted or unsubstituted alkyl, or R5 and R6 or R4 and R5 are taken together to form substituted or unsubstituted alkylene, R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.

    摘要翻译： 公开了由结构式I表示的生长激素促分泌素的新化合物：其中R 1是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的烷氧基，取代或未取代的芳基或取代的 或未取代的氨基，X是-CO-或-SO 2 - ，Y是：其中n是0-4的整数，R 4是氢，取代或未取代的 烷基，取代或未取代的环烷基，取代或未取代的芳基，R 5和R 6独立地选自氢，取代或未取代的烷基或R 5， R S和R 6或R 4和R 5一起形成取代或未取代的亚烷基，R 2 O， >是氢或取代或未取代的烷基，R 3是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的芳基，D是取代或未取代的 取代或未取代的烷氧基，或取代或未取代的烷硫基，*表示在人或动物中具有生长激素释放活性的不对称中心及其药学上可接受的盐和各异构体。

    Rotor attachment apparatus and rotor attachment method
    8.
    发明授权
    Rotor attachment apparatus and rotor attachment method 有权
    转子连接装置及转子安装方法

    公开(公告)号：US08161630B2

    公开(公告)日：2012-04-24

    申请号：US12666233

    申请日：2009-03-03

    申请人： Yoshiaki Takehara ,  Kiyoshi Inoguchi

    发明人： Yoshiaki Takehara ,  Kiyoshi Inoguchi

    IPC分类号： B23P19/00

    CPC分类号： H02K15/02 ,  Y10T29/49009 ,  Y10T29/49011 ,  Y10T29/49012 ,  Y10T29/53143 ,  Y10T29/53161

    摘要： A rotor attachment apparatus for attaching a rotor of a motor coaxially to a crankshaft by inserting the rotor into a rotor housing that is attached to an engine, including: a rotor support member; rotor positioning members that engage some of a plurality of bolt insertion holes provided in the rotor, to thereby position the rotor; a temporary fixation bolt that temporarily fixes the rotor on the rotor support member; a drive shaft a tip portion of which is engaged with a shaft end portion of the crankshaft, and which supports the rotor support member movably in an axis direction via a screw mechanism; a base member that moves the rotor support member toward and away from the rotor while rotatably supporting a base end of the drive shaft; base positioning members that engage the rotor housing; and a fastening mechanism which engages a head of a coupling bolt inserted into at least one of the bolt insertion holes, and which is supported by the rotor support member so as to bias the coupling bolt toward the rotor.

    摘要翻译： 一种转子附接装置，其通过将转子插入到发动机附接的转子壳体中而将马达的转子同轴地附接到曲轴，转子附接装置包括：转子支撑构件; 转子定位构件，其接合设置在转子中的多个螺栓插入孔中的一些，从而定位转子; 临时固定螺栓，其将转子临时固定在转子支撑构件上; 驱动轴，其末端部与曲轴的轴端部接合，并且通过螺纹机构沿轴向方向可移动地支撑转子支撑部件; 基部构件，其使所述转子支撑构件朝向和远离所述转子移动，同时可旋转地支撑所述驱动轴的基端; 接合转子壳体的基座定位构件; 以及紧固机构，其接合插入到至少一个所述螺栓插入孔中的联接螺栓的头部，并且由所述转子支撑构件支撑，以将所述联接螺栓朝向所述转子偏置。

    ROTOR ATTACHMENT APPARATUS AND ROTOR ATTACHMENT METHOD
    9.
    发明申请
    ROTOR ATTACHMENT APPARATUS AND ROTOR ATTACHMENT METHOD 有权
    转子附件装置和转子附件方法

    公开(公告)号：US20110041321A1

    公开(公告)日：2011-02-24

    申请号：US12666233

    申请日：2009-03-03

    申请人： Yoshiaki Takehara ,  Kiyoshi Inoguchi

    发明人： Yoshiaki Takehara ,  Kiyoshi Inoguchi

    IPC分类号： H02K15/02

    CPC分类号： H02K15/02 ,  Y10T29/49009 ,  Y10T29/49011 ,  Y10T29/49012 ,  Y10T29/53143 ,  Y10T29/53161

    摘要： A rotor attachment apparatus for attaching a rotor of a motor coaxially to a crankshaft by inserting the rotor into a rotor housing that is attached to an engine, including: a rotor support member; rotor positioning members that engage some of a plurality of bolt insertion holes provided in the rotor, to thereby position the rotor; a temporary fixation bolt that temporarily fixes the rotor on the rotor support member; a drive shaft a tip portion of which is engaged with a shaft end portion of the crankshaft, and which supports the rotor support member movably in an axis direction via a screw mechanism; a base member that moves the rotor support member toward and away from the rotor while rotatably supporting a base end of the drive shaft; base positioning members that engage the rotor housing; and a fastening mechanism which engages a head of a coupling bolt inserted into at least one of the bolt insertion holes, and which is supported by the rotor support member so as to bias the coupling bolt toward the rotor.

    摘要翻译： 一种转子附接装置，其通过将转子插入到发动机附接的转子壳体中而将马达的转子同轴地附接到曲轴，转子附接装置包括：转子支撑构件; 转子定位构件，其接合设置在转子中的多个螺栓插入孔中的一些，从而定位转子; 临时固定螺栓，其将转子临时固定在转子支撑构件上; 驱动轴，其末端部与曲轴的轴端部接合，并且通过螺纹机构沿轴向方向可移动地支撑转子支撑部件; 基部构件，其使所述转子支撑构件朝向和远离所述转子移动，同时可旋转地支撑所述驱动轴的基端; 接合转子壳体的基座定位构件; 以及紧固机构，其接合插入到至少一个所述螺栓插入孔中的联接螺栓的头部，并且由所述转子支撑构件支撑，以将所述联接螺栓朝向所述转子偏置。