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公开(公告)号：US09238696B2
公开(公告)日：2016-01-19
申请号：US14004839
申请日：2011-12-05
申请人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Yuki Hayashi , Minoru Iwata
发明人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Yuki Hayashi , Minoru Iwata
CPC分类号： C08B37/0015 , C08G65/2606 , C08G65/3331 , C08G65/33396 , C08G2650/04 , C08J3/122 , C08J2305/16 , C08L71/02 , C08L5/16
摘要： The present invention aims to provide a method of producing a powdered hydrophilic modified polyrotaxane, which enables production of a powdered hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way. The present invention provides a method of producing a powdered hydrophilic modified polyrotaxane, comprising: a hydrophilic modification step of preparing a solution of a hydrophilic modified polyrotaxane by modifying all or part of hydroxy groups on a cyclodextrin of a polyrotaxane with hydrophilic modifying groups, the polyrotaxane containing the cyclodextrin, a polyethylene glycol included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a drying step of spraying the prepared solution of the hydrophilic modified polyrotaxane and drying the solution of the hydrophilic modified polyrotaxane in a heated gas stream.
摘要翻译： 本发明的目的在于提供一种生产粉状亲水性改性聚轮烷的方法，该方法能够以工业上有利的方式制备出优良的储存稳定性的亲水改性聚轮烷粉末。 本发明提供一种粉末状亲水性改性聚轮烷的制造方法，其特征在于，包括：亲水改性工序，其通过将聚轮烷的环糊精的全部或部分羟基改性为亲水性改性基来制备亲水改性聚轮烷的溶液，所述聚轮烷 包含环糊精，以串配方式包含在环糊精分子的空腔中的聚乙二醇和位于聚乙二醇的每一端的封端基团，并防止环糊精分子与聚乙二醇的解离; 以及干燥步骤，喷雾亲水改性聚轮烷的制备溶液，并将亲水改性聚轮烷的溶液干燥在加热气流中。
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公开(公告)号：US09205104B2
公开(公告)日：2015-12-08
申请号：US14005137
申请日：2011-12-05
申请人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Changming Zhao , Minoru Iwata , Yuki Hayashi
发明人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Changming Zhao , Minoru Iwata , Yuki Hayashi
IPC分类号： A61K31/724 , C08G65/06 , C08L5/16 , C08L71/02 , C08B37/16 , C08G83/00 , A61K31/192 , A61K31/216 , A61K31/353 , C08L101/00
CPC分类号： A61K31/724 , A61K31/192 , A61K31/216 , A61K31/353 , C08B37/0015 , C08G65/2606 , C08G65/3331 , C08G65/33396 , C08G83/007 , C08G2650/04 , C08K5/005 , C08K5/053 , C08K5/16 , C08L5/16 , C08L71/02 , C08L101/005
摘要： The present invention aims to provide a hydrophilic modified polyrotaxane composition having excellent storage stability. The present invention relates to a hydrophilic modified polyrotaxane composition comprising: a hydrophilic modified polyrotaxane produced by modifying, with hydrophilic modifying groups, all or part of hydroxy groups on a cyclodextrin of a polyrotaxane containing the cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant.
摘要翻译： 本发明的目的在于提供一种具有优异储存稳定性的亲水性改性聚轮烷组合物。 亲水性改性聚轮烷组合物本发明涉及一种亲水改性聚轮烷组合物，它包括：亲水改性聚轮烷，其通过亲水改性基团改性含有环糊精的聚轮烷的环糊精上的全部或部分羟基，包含在空腔中的聚乙二醇 的双环糊精分子，并且封端基团放置在聚乙二醇的每一端，并防止环糊精分子与聚乙二醇的解离; 和多酚抗氧化剂。
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公开(公告)号：US20140066616A1
公开(公告)日：2014-03-06
申请号：US14004849
申请日：2011-12-05
申请人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Yuki Hayashi , Minoru Iwata
发明人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Yuki Hayashi , Minoru Iwata
IPC分类号： C08B37/16
CPC分类号： C08B37/0015 , C08G65/332 , C08G65/3331 , C08G65/33396 , C08G83/007 , C08G2650/04 , C08J3/12 , C08J5/18 , C08L5/16 , C08L71/02
摘要： The present invention aims to provide a method of producing a hydrophilic modified polyrotaxane, which enables production of a hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way. The present invention provides a method of producing a hydrophilic modified polyrotaxane, comprising: a hydrophilic modification step of preparing a solution of a hydrophilic modified polyrotaxane by modifying all or part of hydroxy groups on a cyclodextrin of a polyrotaxane with hydrophilic modifying groups, the polyrotaxane containing the cyclodextrin, a polyethylene glycol included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a drying step in which the prepared solution of the hydrophilic modified polyrotaxane is formed into a thin film state and dried.
摘要翻译： 本发明的目的在于提供一种亲水性改性聚轮烷的制造方法，其能够以工业上有利的方式制造出具有良好的保存稳定性的亲水性改性聚轮烷。 本发明提供一种亲水改性聚轮烷的制造方法，其特征在于，包括：亲水改性工序，其通过在聚轮烷的环糊精上改性亲水性改性基团的全部或一部分羟基来制备亲水改性聚轮烷的溶液，所述聚轮烷含有 环糊精，串联方式包含在环糊精分子的空腔中的聚乙二醇以及置于聚乙二醇的各端的封端基，并防止环糊精分子与聚乙二醇分离; 和干燥步骤，其中制备的亲水改性聚轮烷的溶液形成薄膜状态并干燥。
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公开(公告)号：US20130331562A1
公开(公告)日：2013-12-12
申请号：US13994566
申请日：2011-12-05
IPC分类号： C08G83/00
CPC分类号： C08G83/007 , C08B37/0015 , C08G83/006 , C08L71/02 , C08L5/16
摘要： The present invention aims to provide a method for producing a refined polyrotaxane which includes an industrially advantageous method of producing a polyrotaxane that has excellent storage stability. The method for producing a refined polyrotaxane includes the step of heat-cleaning a polyrotaxane with a cleaning medium, the polyrotaxane containing cyclodextrin molecules, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol.
摘要翻译： 本发明的目的在于提供一种精制聚轮烷的制造方法，其特征在于，具有工业上优良的储存稳定性优异的聚轮烷的制造方法。 精制聚轮烷的制造方法包括：利用清洗介质热处理聚轮烷，含有聚环氧丙烷的环糊精分子，以串列方式包含在环糊精分子的空腔中的聚乙二醇，以及封端基 放置在聚乙二醇的每一端，并防止环糊精分子与聚乙二醇分解。
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公开(公告)号：US09068051B2
公开(公告)日：2015-06-30
申请号：US13994566
申请日：2011-12-05
CPC分类号： C08G83/007 , C08B37/0015 , C08G83/006 , C08L71/02 , C08L5/16
摘要： The present invention aims to provide a method for producing a refined polyrotaxane which includes an industrially advantageous method of producing a polyrotaxane that has excellent storage stability. The method for producing a refined polyrotaxane includes the step of heat-cleaning a polyrotaxane with a cleaning medium, the polyrotaxane containing cyclodextrin molecules, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol.
摘要翻译： 本发明的目的在于提供一种精制聚轮烷的制造方法，其特征在于，具有工业上优良的储存稳定性优异的聚轮烷的制造方法。 精制聚轮烷的制造方法包括：利用清洗介质热处理聚轮烷，含有聚环氧丙烷的环糊精分子，以串列方式包含在环糊精分子的空腔中的聚乙二醇，以及封端基 放置在聚乙二醇的每一端，并防止环糊精分子与聚乙二醇分解。
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公开(公告)号：US20140058078A1
公开(公告)日：2014-02-27
申请号：US14004855
申请日：2011-12-05
申请人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Changming Zhao , Minoru Iwata , Yuki Hayashi
发明人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Changming Zhao , Minoru Iwata , Yuki Hayashi
IPC分类号： C08B37/16
CPC分类号： C08B37/0015 , C08G65/2606 , C08G65/3331 , C08G65/33396 , C08G83/007 , C08G2650/04 , C08K5/005 , C08K5/053 , C08L5/16 , C08L71/02
摘要： The present invention aims to provide a polyrotaxane composition having excellent storage stability. The present invention relates to a polyrotaxane composition comprising: a polyrotaxane containing a cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant.
摘要翻译： 本发明的目的在于提供一种储存稳定性优异的聚轮烷组合物。 本发明涉及一种聚轮烷组合物，其包含：含有环糊精的聚轮烷，以串列方式包含在环糊精分子的空腔中的聚乙二醇和位于聚乙二醇的两端的封端基，并防止 环糊精分子与聚乙二醇的解离; 和多酚抗氧化剂。
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公开(公告)号：US20130296547A1
公开(公告)日：2013-11-07
申请号：US13994551
申请日：2011-12-05
IPC分类号： C08G83/00
CPC分类号： C08G83/007 , C08B37/0015 , C08G83/008 , C08J3/03 , C08J3/16 , C08J2305/16 , C08J2371/02 , C08L71/02 , C08L5/16
摘要： The present invention aims to provide an industrially advantageous method for producing an aqueous dispersion of pseudopolyrotaxane enabling to produce an aqueous dispersion of pseudopolyrotaxane having good fluidity and excellent dispersion stability of the pseudopolyrotaxane particles therein. The present invention relates to a method for producing an aqueous dispersion of pseudopolyrotaxane. The method includes: a mixing step of a dissolving polyethylene glycol and a cyclodextrin in an aqueous medium to prepare a mixed solution; and a cooling step of continuously or intermittently cooling the mixed solution in a state of flux to precipitate pseudopolyrotaxane particles. The pseudopolyrotaxane particles contain the polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner.
摘要翻译： 本发明的目的在于提供一种工业上有利的方法，用于制备准聚轮烷的水性分散体，其能够制备具有良好的流动性和优异的其中的大聚轮烷粒子的分散稳定性的假聚轮烷的水分散体。 本发明涉及一种制备假聚轮烷水分散体的方法。 该方法包括：在水性介质中混合溶解聚乙二醇和环糊精以制备混合溶液的步骤; 以及冷却步骤，以通量的状态连续地或间歇地冷却混合溶液，以沉淀出准聚轮烷颗粒。 假多齿轮颗粒包含以串行方式包含在环糊精分子的空腔中的聚乙二醇。
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公开(公告)号：US09475908B2
公开(公告)日：2016-10-25
申请号：US13994551
申请日：2011-12-05
CPC分类号： C08G83/007 , C08B37/0015 , C08G83/008 , C08J3/03 , C08J3/16 , C08J2305/16 , C08J2371/02 , C08L71/02 , C08L5/16
摘要： The present invention aims to provide an industrially advantageous method for producing an aqueous dispersion of pseudopolyrotaxane enabling to produce an aqueous dispersion of pseudopolyrotaxane having good fluidity and excellent dispersion stability of the pseudopolyrotaxane particles therein. The present invention relates to a method for producing an aqueous dispersion of pseudopolyrotaxane. The method includes: a mixing step of a dissolving polyethylene glycol and a cyclodextrin in an aqueous medium to prepare a mixed solution; and a cooling step of continuously or intermittently cooling the mixed solution in a state of flux to precipitate pseudopolyrotaxane particles. The pseudopolyrotaxane particles contain the polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner.
摘要翻译： 本发明的目的在于提供一种工业上有利的方法，用于制备准聚轮烷的水性分散体，其能够制备具有良好的流动性和优异的其中的大聚轮烷粒子的分散稳定性的假聚轮烷的水分散体。 本发明涉及一种制备假聚轮烷水分散体的方法。 该方法包括：在水性介质中混合溶解聚乙二醇和环糊精以制备混合溶液的步骤; 以及冷却步骤，以通量的状态连续地或间歇地冷却混合溶液，以沉淀出准聚轮烷颗粒。 假多齿轮颗粒包含以串行方式包含在环糊精分子的空腔中的聚乙二醇。
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公开(公告)号：US20140066615A1
公开(公告)日：2014-03-06
申请号：US14004839
申请日：2011-12-05
申请人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Yuki Hayashi , Minoru Iwata
发明人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Yuki Hayashi , Minoru Iwata
IPC分类号： C08B37/16
CPC分类号： C08B37/0015 , C08G65/2606 , C08G65/3331 , C08G65/33396 , C08G2650/04 , C08J3/122 , C08J2305/16 , C08L71/02 , C08L5/16
摘要： The present invention aims to provide a method of producing a powdered hydrophilic modified polyrotaxane, which enables production of a powdered hydrophilic modified polyrotaxane excellent in storage stability in an industrially advantageous way. The present invention provides a method of producing a powdered hydrophilic modified polyrotaxane, comprising: a hydrophilic modification step of preparing a solution of a hydrophilic modified polyrotaxane by modifying all or part of hydroxy groups on a cyclodextrin of a polyrotaxane with hydrophilic modifying groups, the polyrotaxane containing the cyclodextrin, a polyethylene glycol included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a drying step of spraying the prepared solution of the hydrophilic modified polyrotaxane and drying the solution of the hydrophilic modified polyrotaxane in a heated gas stream.
摘要翻译： 本发明的目的在于提供一种生产粉状亲水性改性聚轮烷的方法，该方法能够以工业上有利的方式制备出优良的储存稳定性的亲水改性聚轮烷粉末。 本发明提供一种粉末状亲水性改性聚轮烷的制造方法，其特征在于，包括：亲水改性工序，其通过将聚轮烷的环糊精的全部或部分羟基改性为亲水性改性基来制备亲水改性聚轮烷的溶液，所述聚轮烷 包含环糊精，以串配方式包含在环糊精分子的空腔中的聚乙二醇和位于聚乙二醇的每一端的封端基团，并防止环糊精分子与聚乙二醇的解离; 以及干燥步骤，喷雾亲水改性聚轮烷的制备溶液，并将亲水改性聚轮烷的溶液干燥在加热气流中。
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公开(公告)号：US20140066403A1
公开(公告)日：2014-03-06
申请号：US14005137
申请日：2011-12-05
申请人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Changming Zhao , Minoru Iwata , Yuki Hayashi
发明人： Tomoaki Yamasaki , Shinya Okazaki , Hiroki Okazaki , Shigeki Hamamoto , Changming Zhao , Minoru Iwata , Yuki Hayashi
IPC分类号： A61K31/724 , A61K31/192 , A61K31/353 , A61K31/216
CPC分类号： A61K31/724 , A61K31/192 , A61K31/216 , A61K31/353 , C08B37/0015 , C08G65/2606 , C08G65/3331 , C08G65/33396 , C08G83/007 , C08G2650/04 , C08K5/005 , C08K5/053 , C08K5/16 , C08L5/16 , C08L71/02 , C08L101/005
摘要： The present invention aims to provide a hydrophilic modified polyrotaxane composition having excellent storage stability. The present invention relates to a hydrophilic modified polyrotaxane composition comprising: a hydrophilic modified polyrotaxane produced by modifying, with hydrophilic modifying groups, all or part of hydroxy groups on a cyclodextrin of a polyrotaxane containing the cyclodextrin, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol; and a polyphenol antioxidant.
摘要翻译： 本发明的目的在于提供一种具有优异储存稳定性的亲水性改性聚轮烷组合物。 亲水性改性聚轮烷组合物本发明涉及一种亲水改性聚轮烷组合物，它包括：亲水改性聚轮烷，其通过亲水改性基团改性含有环糊精的聚轮烷的环糊精上的全部或部分羟基，包含在空腔中的聚乙二醇 的双环糊精分子，并且封端基团放置在聚乙二醇的每一端，并防止环糊精分子与聚乙二醇的解离; 和多酚抗氧化剂。
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