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    Polyprenylcarboxylic acid morpholides and pharmaceutical compositions
    5.
    发明授权
    Polyprenylcarboxylic acid morpholides and pharmaceutical compositions 失效
    聚丙烯酰羧酸吗啉和药物组合物

    公开(公告)号：US4639450A

    公开(公告)日：1987-01-27

    申请号：US677893

    申请日：1984-12-04

    申请人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

    发明人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

    IPC分类号： C07C51/08 ,  C07C51/60 ,  C07D295/185 ,  C07D317/58 ,  A61K31/535 ,  C07D295/18

    CPC分类号： C07D295/185 ,  C07C51/08 ,  C07C51/60 ,  C07D317/58 ,  Y10S514/893

    摘要： This invention relates to polyprenylcarboxylic acid amides represented by the following general formula (I): ##STR1## wherein n is an integer of from 1 to 4, a and b stand for hydrogen atoms or a direct valence bond between the carbon atoms to which a and b are attached, c and d stand for hydrogen atoms or a direct valence bond between the carbon atoms to which c and d are attached, and R.sub.1 and R.sub.2 stand for a hydrogen atom, a lower alkyl group, a phenyl group which may be substituted or an aralkyl group which may be substituted, or R.sub.1 and R.sub.2 form, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may contain other hetero atoms or may be substituted,and also to a process for the preparation of said polyprenylcarboxylic acid amide and to a pharmaceutical composition for treating liver dysfunction comprising said polyprenylcarboxylic acid amide.

    摘要翻译： 本发明涉及由以下通式（I）表示的聚异戊二烯羧酸酰胺：其中n为1至4的整数，a和b代表氢原子或碳原子之间的直接键键 a和b连接在一起，c和d代表氢原子或c和d连接的碳原子之间的直接键键，R1和R2代表氢原子，低级烷基，苯基 或可以被取代的芳烷基，或者R 1和R 2与相邻的氮原子一起形成可含有其它杂原子或可被取代的5-或6-元杂环，也可以与 用于制备所述聚异戊二烯基羧酸酰胺的方法和用于治疗包含所述聚异戊二烯基羧酸酰胺的肝功能障碍的药物组合物。