公开(公告)号：US4883916A

公开(公告)日：1989-11-28

申请号：US176637

申请日：1988-04-01

申请人： Kouji Nakamoto ,  Takeshi Suzuki ,  Shinya Abe ,  Kenji Hayashi ,  Akiharu Kajiwara ,  Isao Yamatsu ,  Issei Otsuka ,  Hiroyuki Shiojiri

发明人： Kouji Nakamoto ,  Takeshi Suzuki ,  Shinya Abe ,  Kenji Hayashi ,  Akiharu Kajiwara ,  Isao Yamatsu ,  Issei Otsuka ,  Hiroyuki Shiojiri

IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61P3/06 ,  A61P9/10 ,  C07C51/00 ,  C07C57/30 ,  C07C57/42 ,  C07C61/39 ,  C07C63/04 ,  C07C67/00 ,  C07C233/17 ,  C07C233/23 ,  C07C233/69 ,  C07C237/08 ,  C07C237/20 ,  C07C237/22

CPC分类号： C07C63/04 ,  C07C57/30 ,  C07C57/42

摘要： A polyprenyl compound terminated with a group of ##STR1## is novel and useful as an antihypercholesterolemic agent and an antiarteriosclerotic agent, in which X is a group of the formula ##STR2## wherein K and L are independently a hydrogen atom or form a single valence bond between the carbon atoms to which they are attached, a group represented by the formula --CH.sub.2 -- or a group represented by the formula --(CH.sub.2).sub.2 --, m is an integer of 0 or 1, and R stands for a hydroxy group, a group represented by the Formula ##STR3## wherein R.sup.1 and R.sup.2 may be the same or different and each stands for a hydrogen atom or a lower alkyl group and p stands for an integer of 1 or 2, a group represented by the formula --NH--(CH.sub.2).sub.q --OH (wherein q denotes an integer of 1 or 2) or a group represented by the formula ##STR4##

公开(公告)号：US4788330A

公开(公告)日：1988-11-29

申请号：US37472

申请日：1986-03-07

申请人： Kouji Nakamoto ,  Takeshi Suzuki ,  Shinya Abe ,  Kenji Hayashi ,  Akiharu Kajiwara ,  Isao Yamatsu ,  Issei Otsuka ,  Hiroyuki Shiojiri

发明人： Kouji Nakamoto ,  Takeshi Suzuki ,  Shinya Abe ,  Kenji Hayashi ,  Akiharu Kajiwara ,  Isao Yamatsu ,  Issei Otsuka ,  Hiroyuki Shiojiri

IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61P3/06 ,  A61P9/10 ,  C07C51/00 ,  C07C57/30 ,  C07C57/42 ,  C07C61/39 ,  C07C63/04 ,  C07C67/00 ,  C07C233/17 ,  C07C233/23 ,  C07C233/69 ,  C07C237/08 ,  C07C237/20 ,  C07C237/22

CPC分类号： C07C63/04 ,  C07C57/30 ,  C07C57/42

摘要： A polyprenyl compound terminated with a group of ##STR1## is novel and useful as an antihypercholesterolemic agent and an antiarteriosclerotic agent, in which X is a group of the formula ##STR2## (wherein K and L are independently a hydrogen atom or form a single valence bond between the carbon atoms to which they are attached), a group represented by the formula --CH.sub.2 -- or a group represented by the formula --(CH.sub.2).sub.2 --, m is an integer of 0 or 1, and R stands for a hydroxy group, a group represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 may be the same or different and each stands for a hydrogen atom or a lower alkyl group and p stands for an integer of 1 or 2, a group represented by the formula --NH--(CH.sub.2).sub.q --OH (wherein q denotes an integer of 1 or 2) or a group represented by the formula

摘要翻译： 以“IMAGE”组封端的聚异戊二烯基化合物作为抗高胆固醇血症药和抗动脉硬化药物是新颖的，其中X是下式的基团（其中K和L独立地是氢原子或形成单一的 它们所连接的碳原子之间的价键），由式-CH2-表示的基团或由式 - （CH 2）2表示的基团，m是0或1的整数，R代表 羟基，由式“IMAGE”表示的基团，其中R 1和R 2可以相同或不同，各自表示氢原子或低级烷基，p表示1或2的整数，由 式-NH-（CH 2）q -OH（其中q表示1或2的整数）或由式表示的基团

公开(公告)号：US4481217A

公开(公告)日：1984-11-06

申请号：US269930

申请日：1981-05-28

申请人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kuniko Hara

发明人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kuniko Hara

IPC分类号： A61K31/045 ,  A61K31/23 ,  C07C29/147 ,  C07C33/02 ,  C07C33/025 ,  C07C57/03 ,  C07C67/08 ,  C07C69/533 ,  C07C69/587 ,  A61K31/22

CPC分类号： C07C255/00 ,  C07C29/147 ,  C07C33/02 ,  C07C33/025 ,  C07C57/03 ,  C07C67/08 ,  C07C69/145 ,  C07C69/587 ,  Y10S514/894

摘要： An .alpha.,.beta.-dihydropolyprenyl derivative having the formula (I): ##STR1## wherein X represents a group of --COOR.sub.1 or --CH.sub.2 OR.sub.2 in which R.sub.1 is the hydrogen atom or a lower alkyl group and R.sub.2 is the hydrogen atom or an aliphatic acyl group having one to four carbon atoms; and n is an integer of one to four. A process for the preparation of the .alpha.,.beta.-dihydropolyprenyl derivative and a therapeutic agent for treatment of liver diseases comprising the same are also disclosed.

摘要翻译： 具有式（I）的α，β-二氢聚芘基衍生物：其中X表示-COOR1或-CH2OR2的基团，其中R1是氢原子或低级烷基，R2是氢原子或 具有1-4个碳原子的脂族酰基; n为1〜4的整数。 还公开了制备α，β-二氢聚芘基衍生物的方法和用于治疗包含其的肝病的治疗剂。

公开(公告)号：US4456603A

公开(公告)日：1984-06-26

申请号：US175213

申请日：1980-08-04

申请人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

发明人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

IPC分类号： C07C51/08 ,  C07C51/60 ,  C07D295/185 ,  C07D317/58 ,  A61K31/445 ,  A61K31/535

CPC分类号： C07D295/185 ,  C07C51/08 ,  C07C51/60 ,  C07D317/58 ,  Y10S514/893

摘要： Polyprenyl carboxylic acid amides of the formula ##STR1## process for their preparation and use thereof for treating liver dysfunction are disclosed.

摘要翻译： 公开了其用于治疗肝功能障碍的其制备及其用途的式“IMAGE”方法的聚丙烯酰羧酸酰胺。

公开(公告)号：US4639450A

公开(公告)日：1987-01-27

申请号：US677893

申请日：1984-12-04

申请人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

发明人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kumiko Hara

IPC分类号： C07C51/08 ,  C07C51/60 ,  C07D295/185 ,  C07D317/58 ,  A61K31/535 ,  C07D295/18

CPC分类号： C07D295/185 ,  C07C51/08 ,  C07C51/60 ,  C07D317/58 ,  Y10S514/893

摘要： This invention relates to polyprenylcarboxylic acid amides represented by the following general formula (I): ##STR1## wherein n is an integer of from 1 to 4, a and b stand for hydrogen atoms or a direct valence bond between the carbon atoms to which a and b are attached, c and d stand for hydrogen atoms or a direct valence bond between the carbon atoms to which c and d are attached, and R.sub.1 and R.sub.2 stand for a hydrogen atom, a lower alkyl group, a phenyl group which may be substituted or an aralkyl group which may be substituted, or R.sub.1 and R.sub.2 form, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may contain other hetero atoms or may be substituted,and also to a process for the preparation of said polyprenylcarboxylic acid amide and to a pharmaceutical composition for treating liver dysfunction comprising said polyprenylcarboxylic acid amide.

摘要翻译： 本发明涉及由以下通式（I）表示的聚异戊二烯羧酸酰胺：其中n为1至4的整数，a和b代表氢原子或碳原子之间的直接键键 a和b连接在一起，c和d代表氢原子或c和d连接的碳原子之间的直接键键，R1和R2代表氢原子，低级烷基，苯基 或可以被取代的芳烷基，或者R 1和R 2与相邻的氮原子一起形成可含有其它杂原子或可被取代的5-或6-元杂环，也可以与 用于制备所述聚异戊二烯基羧酸酰胺的方法和用于治疗包含所述聚异戊二烯基羧酸酰胺的肝功能障碍的药物组合物。

公开(公告)号：US4571408A

公开(公告)日：1986-02-18

申请号：US543748

申请日：1983-10-20

申请人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kuniko Hara

发明人： Isao Yamatsu ,  Yuichi Inai ,  Shinya Abe ,  Hideaki Watanabe ,  Toshiji Igarashi ,  Hiroyuki Shiojiri ,  Yoshio Tanabe ,  Kuniko Hara

IPC分类号： A61K31/045 ,  A61K31/23 ,  C07C29/147 ,  C07C33/02 ,  C07C33/025 ,  C07C57/03 ,  C07C67/08 ,  C07C69/533 ,  C07C69/587 ,  A61K31/22

CPC分类号： C07C255/00 ,  C07C29/147 ,  C07C33/02 ,  C07C33/025 ,  C07C57/03 ,  C07C67/08 ,  C07C69/145 ,  C07C69/587 ,  Y10S514/894

摘要： An .alpha.,.beta.-dihydropolyprenyl derivative having the formula (I): ##STR1## wherein X represents a group of --COOR.sub.1 or --CH.sub.2 OR.sub.2 in which R.sub.1 is the hydrogen atom or an alkyl group having one to four carbon atoms and R.sub.2 is the hydrogen atom or an aliphatic acyl group having one to four carbon atoms; and n is an integer of one to four. A process for the preparation of the .alpha.,.beta.-dihydropolyprenyl derivative and a therapeutic agent for treatment of liver diseases comprising the same are also disclosed.