公开(公告)号：US20120004506A1

公开(公告)日：2012-01-05

申请号：US13152784

申请日：2011-06-03

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

IPC分类号： A61B1/00

CPC分类号： A61B1/00082 ,  A61B1/00064 ,  A61B1/00071 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00179 ,  A61B5/6852 ,  A61B5/6853

摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

摘要翻译： 根据本公开的示例性实施例，可以提供可以使用光学技术来促进生物组织例如体内器官的成像的装置和方法。 示例性装置可以包括不同的设计，一个或多个导管的特征可以照亮组织，并从内腔收集信号。 在根据本公开的另一示例性实施例中，球囊导管可以设置有柔性颈部，其可以吸收大部分的弯曲。 根据本公开的另一示例性实施例，可以提供球囊 - 导管系留胶囊，并且根据另外的示例性实施例，结构化球囊设计可以设置有一个或多个突起，从而能够使结构在近距离成像 接触，例如，不压缩组织。

公开(公告)号：US10285568B2

公开(公告)日：2019-05-14

申请号：US13152784

申请日：2011-06-03

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

IPC分类号： A61B1/00 ,  A61B5/00

摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

公开(公告)号：US09557154B2

公开(公告)日：2017-01-31

申请号：US13114845

申请日：2011-05-24

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC分类号： A61B5/00 ,  G01B9/02 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US20120101374A1

公开(公告)日：2012-04-26

申请号：US13114845

申请日：2011-05-24

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US20110137178A1

公开(公告)日：2011-06-09

申请号：US12899524

申请日：2010-10-06

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Hongki Yoo

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Dongkyun Kang ,  Hongki Yoo

IPC分类号： A61B6/00

CPC分类号： A61B5/411 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/037 ,  A61B5/4233 ,  A61B5/68 ,  A61B5/6852 ,  A61B5/6853 ,  G02B21/0064 ,  G02B21/0076

摘要： An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.

摘要翻译： 可以提供根据本公开的装置和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。 使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。 此外，使用至少三分之一布置，可以基于第二电磁辐射将部分中的至少一种特定的嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或营养细胞与其他细胞区分开。