公开(公告)号：US10285568B2

公开(公告)日：2019-05-14

申请号：US13152784

申请日：2011-06-03

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

IPC分类号： A61B1/00 ,  A61B5/00

摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

公开(公告)号：US20120004506A1

公开(公告)日：2012-01-05

申请号：US13152784

申请日：2011-06-03

申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Michalina Gora ,  Melissa Suter ,  Hongki Yoo ,  Milen Shishkov

IPC分类号： A61B1/00

CPC分类号： A61B1/00082 ,  A61B1/00064 ,  A61B1/00071 ,  A61B1/0008 ,  A61B1/00165 ,  A61B1/00179 ,  A61B5/6852 ,  A61B5/6853

摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.

摘要翻译： 根据本公开的示例性实施例，可以提供可以使用光学技术来促进生物组织例如体内器官的成像的装置和方法。 示例性装置可以包括不同的设计，一个或多个导管的特征可以照亮组织，并从内腔收集信号。 在根据本公开的另一示例性实施例中，球囊导管可以设置有柔性颈部，其可以吸收大部分的弯曲。 根据本公开的另一示例性实施例，可以提供球囊 - 导管系留胶囊，并且根据另外的示例性实施例，结构化球囊设计可以设置有一个或多个突起，从而能够使结构在近距离成像 接触，例如，不压缩组织。

公开(公告)号：US20120101374A1

公开(公告)日：2012-04-26

申请号：US13114845

申请日：2011-05-24

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC分类号： A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置成经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US09557154B2

公开(公告)日：2017-01-31

申请号：US13114845

申请日：2011-05-24

申请人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

发明人： Guillermo J. Tearney ,  Brett Eugene Bouma ,  Hongki Yoo ,  Milen Shishkov ,  Joseph Gardecki ,  Roman Shubochkin ,  Theodore Morse ,  Farouc Amin Jaffer

IPC分类号： A61B5/00 ,  G01B9/02 ,  G01N21/47 ,  G01N21/64 ,  G01N21/65

CPC分类号： A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

摘要： Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

摘要翻译： 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光纤芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：US07366376B2

公开(公告)日：2008-04-29

申请号：US11241907

申请日：2005-09-29

申请人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

发明人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

IPC分类号： G02B6/32 ,  G02B6/12 ,  G02B6/26 ,  G02B6/42 ,  G02B6/44 ,  G02B6/02 ,  G02B6/028 ,  G02B6/032 ,  G02B6/036

CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

摘要翻译： 提供了用于传送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

公开(公告)号：US09646377B2

公开(公告)日：2017-05-09

申请号：US14243508

申请日：2014-04-02

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc ,  Norman S. Nishioka

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc ,  Norman S. Nishioka

IPC分类号： A61B5/00 ,  G06T7/00

CPC分类号： A61B5/0084 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/6852 ,  A61B5/7271 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10101

摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

公开(公告)号：USRE43875E1

公开(公告)日：2012-12-25

申请号：US12323228

申请日：2008-11-25

申请人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

发明人： Milen Shishkov ,  Brett Eugene Bouma ,  Guillermo J. Tearney

IPC分类号： G02B6/32 ,  G02B6/12 ,  G02B6/26 ,  G02B6/42 ,  G02B6/44 ,  G02B6/02 ,  G02B6/028 ,  G02B6/032 ,  G02B6/036

CPC分类号： H04J14/0267 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  G02B6/2552 ,  G02B6/262 ,  G02B6/2856

摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.

摘要翻译： 提供了用于传送至少一个电磁辐射的装置和方法。 特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。 此外，可以与光纤光学协作地提供透光的光学装置。 光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。 第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

公开(公告)号：US20110178398A1

公开(公告)日：2011-07-21

申请号：US12946725

申请日：2010-11-15

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

IPC分类号： A61B6/00

CPC分类号： A61B5/6852 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007

摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.

摘要翻译： 提供了一种用于对与不透明流体接触的结构的表面进行成像的装置，方法和软件装置。 该装置包括制品（例如，壳体），流体输送装置和成像装置。 壳体包括形成在制品中的孔。 流体输送装置构造成将一定体积的基本上透明的流体输送到形成在壳体中的孔。 成像装置被配置为在将透明流体的体积传送到孔之后使用成像模态来对结构的表面进行成像，其中成像装置和/或制品在结构的表面上被平移，而成像 结构的表面。

公开(公告)号：US10426548B2

公开(公告)日：2019-10-01

申请号：US11670043

申请日：2007-02-01

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma ,  Benjamin J. Vakoc

IPC分类号： A61B5/00 ,  A61B18/22 ,  A61B18/24 ,  A61B17/00 ,  A61B17/22

摘要： According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.

公开(公告)号：US09254102B2

公开(公告)日：2016-02-09

申请号：US13226274

申请日：2011-09-06

申请人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

发明人： Guillermo J. Tearney ,  Milen Shishkov ,  Brett Eugene Bouma

IPC分类号： A61B6/00 ,  A61B5/00 ,  A61B5/02

CPC分类号： A61B5/6852 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/02007

摘要： An apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided. The apparatus includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement. The housing includes an aperture formed in the article of manufacture. The fluid delivery arrangement is configured to deliver a volume of substantially transparent fluid to the aperture formed in the housing. The imaging arrangement is configured to image the surface of the structure using an imaging modality after the volume of the transparent fluid is delivered to the aperture, wherein the imaging arrangement and/or the article of manufacture is translated along the surface of the structure while imaging the surface of the structure.