Pharmaceutical liquid composition of botulinum toxin with improved stability
    3.
    发明授权
    Pharmaceutical liquid composition of botulinum toxin with improved stability 有权
    肉毒杆菌毒素的药物液体组合物具有改善的稳定性

    公开(公告)号:US08617568B2

    公开(公告)日:2013-12-31

    申请号:US12666592

    申请日:2008-05-28

    IPC分类号: A61K39/08

    摘要: Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25˜370C as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.

    摘要翻译: 本文公开了一种稳定性提高的肉毒杆菌毒素的液体药物组合物。 它包括肉毒杆菌毒素,聚山梨醇酯20,甲硫氨酸和任选的异亮氨酸。 采用代替动物来源的蛋白质白蛋白或明胶,聚山梨醇酯20与甲硫氨酸和任选的异亮氨酸作为肉毒杆菌毒素稳定剂的组合,液体药物组合物消除了用血清衍生的病原体或微生物污染身体的风险,并且可以施用 安全地到身体。 此外,该组合物可方便地用作患者的直接注射剂。 对于在25〜370℃以及在冷藏温度下肉毒杆菌毒素的储存稳定性方面使用洗涤剂或氨基酸的常规组合物,优选本发明的液体药物组合物在紧急情况下储存肉毒杆菌毒素非常有用, 作为不保持低温的环境。 液体药物组合物可以容易地制备,因为它使用洗涤剂和氨基酸而没有冷冻干燥过程。

    Mobile communication terminal and method for providing RFID technique
    4.
    发明授权
    Mobile communication terminal and method for providing RFID technique 有权
    移动通信终端和提供RFID技术的方法

    公开(公告)号:US07710241B2

    公开(公告)日:2010-05-04

    申请号:US11670050

    申请日:2007-02-01

    申请人: Hyun-Ho Jung

    发明人: Hyun-Ho Jung

    IPC分类号: H04Q5/22

    摘要: A mobile communication terminal and method for providing an RFID technique is provided. The terminal includes an RFID reader unit for receiving identification information from an RFID tag and a controller for detecting a pre-set theme corresponding to the identification information and outputting a control signal based on the detected theme.

    摘要翻译: 提供了一种用于提供RFID技术的移动通信终端和方法。 终端包括用于从RFID标签接收识别信息的RFID读取器单元和用于检测与识别信息相对应的预设主题的控制器,并且基于检测到的主题输出控制信号。

    Pharmaceutical Liquid Composition of Botulinum Toxin With Improved Stability
    6.
    发明申请
    Pharmaceutical Liquid Composition of Botulinum Toxin With Improved Stability 有权
    肉毒毒素药物液体组成改善稳定性

    公开(公告)号:US20100291136A1

    公开(公告)日:2010-11-18

    申请号:US12666592

    申请日:2008-05-28

    摘要: Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25˜370 C as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.

    摘要翻译: 本文公开了一种稳定性提高的肉毒杆菌毒素的液体药物组合物。 它包括肉毒杆菌毒素,聚山梨醇酯20,甲硫氨酸和任选的异亮氨酸。 采用代替动物来源的蛋白质白蛋白或明胶,聚山梨醇酯20与甲硫氨酸和任选的异亮氨酸作为肉毒杆菌毒素稳定剂的组合,液体药物组合物消除了用血清衍生的病原体或微生物污染身体的风险,并且可以施用 安全地到身体。 此外,该组合物可方便地用作患者的直接注射剂。 对于在25〜370℃以及在冷藏温度下肉毒杆菌毒素的储存稳定性方面使用洗涤剂或氨基酸的常规组合物,优选本发明的液体药物组合物在紧急情况下储存肉毒杆菌毒素非常有用 如不保持低温的环境。 液体药物组合物可以容易地制备,因为它使用洗涤剂和氨基酸而没有冷冻干燥过程。

    Method of manufacturing semiconductor device
    7.
    发明授权
    Method of manufacturing semiconductor device 有权
    制造半导体器件的方法

    公开(公告)号:US08735248B2

    公开(公告)日:2014-05-27

    申请号:US13475329

    申请日:2012-05-18

    CPC分类号: H01L29/66795

    摘要: A method of manufacturing a semiconductor device is provided. The method includes providing a substrate having a protruding channel region, forming a gate insulation layer surrounding the protruding channel region, forming a sacrificial layer having an etch selectivity varying in a thickness direction of the sacrificial layer, on the gate insulation layer, and performing a gate-last process to form a gate electrode on the gate insulation layer in place of the sacrificial layer.

    摘要翻译: 提供一种制造半导体器件的方法。 该方法包括提供具有突出沟道区的衬底,形成围绕突出沟道区的栅极绝缘层,在栅绝缘层上形成具有沿牺牲层的厚度方向变化的蚀刻选择性的牺牲层,并执行 栅极最后工艺,以在栅极绝缘层上形成栅电极来代替牺牲层。

    METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE
    9.
    发明申请
    METHOD OF MANUFACTURING SEMICONDUCTOR DEVICE 有权
    制造半导体器件的方法

    公开(公告)号:US20120302034A1

    公开(公告)日:2012-11-29

    申请号:US13475329

    申请日:2012-05-18

    IPC分类号: H01L21/336 H01L21/76

    CPC分类号: H01L29/66795

    摘要: A method of manufacturing a semiconductor device is provided. The method includes providing a substrate having a protruding channel region, forming a gate insulation layer surrounding the protruding channel region, forming a sacrificial layer having an etch selectivity varying in a thickness direction of the sacrificial layer, on the gate insulation layer, and performing a gate-last process to form a gate electrode on the gate insulation layer in place of the sacrificial layer.

    摘要翻译: 提供一种制造半导体器件的方法。 该方法包括提供具有突出沟道区的衬底,形成围绕突出沟道区的栅极绝缘层,在栅绝缘层上形成具有沿牺牲层的厚度方向变化的蚀刻选择性的牺牲层,并执行 栅极最后工艺,以在栅极绝缘层上形成栅电极来代替牺牲层。

    MOBILE COMMUNICATION TERMINAL AND METHOD FOR PROVIDING RFID TECHNIQUE
    10.
    发明申请
    MOBILE COMMUNICATION TERMINAL AND METHOD FOR PROVIDING RFID TECHNIQUE 有权
    移动通信终端和提供RFID技术的方法

    公开(公告)号:US20070181665A1

    公开(公告)日:2007-08-09

    申请号:US11670050

    申请日:2007-02-01

    申请人: Hyun-Ho Jung

    发明人: Hyun-Ho Jung

    IPC分类号: G06F17/00 G06F15/177

    摘要: A mobile communication terminal and method for providing an RFID technique is provided. The terminal includes an RFID reader unit for receiving identification information from an RFID tag and a controller for detecting a pre-set theme corresponding to the identification information and outputting a control signal based on the detected theme.

    摘要翻译: 提供了一种用于提供RFID技术的移动通信终端和方法。 终端包括用于从RFID标签接收识别信息的RFID读取器单元和用于检测与识别信息相对应的预设主题的控制器,并且基于检测到的主题输出控制信号。