公开(公告)号：US20100056780A1

公开(公告)日：2010-03-04

申请号：US12614634

申请日：2009-11-09

申请人： Tae-Sook JEONG ,  Woo-Song LEE ,  Hyung-Jae JEONG ,  Yong-Dae PARK ,  Jong-Min HAN ,  Hyoung-Chin KIM ,  Og-Sung MOON ,  Young-Suk WON

发明人： Tae-Sook JEONG ,  Woo-Song LEE ,  Hyung-Jae JEONG ,  Yong-Dae PARK ,  Jong-Min HAN ,  Hyoung-Chin KIM ,  Og-Sung MOON ,  Young-Suk WON

IPC分类号： C07D295/10 ,  C07C229/00 ,  C07D333/38

CPC分类号： C07C251/68 ,  C07C251/66 ,  C07D207/335 ,  C07D295/205 ,  C07D307/52 ,  C07D307/68 ,  C07D333/22 ,  C07D333/38

摘要： The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease.The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.

摘要翻译： 本发明涉及新型O-酰氧基肟衍生物，其制备方法以及包含其的用于预防和治疗心血管疾病的药物组合物。 根据本发明的O-酰氧基肟衍生物可以用于预防和治疗由Lp-PLA2引起的高脂血症，冠状动脉心脏病，动脉粥样硬化和心肌梗塞等心血管疾病，因为它们具有优异的Lp- PLA2。

公开(公告)号：US08399662B2

公开(公告)日：2013-03-19

申请号：US12614634

申请日：2009-11-09

申请人： Tae-Sook Jeong ,  Woo-Song Lee ,  Hyung-Jae Jeong ,  Yong-Dae Park ,  Jong-Min Han ,  Hyoung-Chin Kim ,  Og-Sung Moon ,  Young-Suk Won

发明人： Tae-Sook Jeong ,  Woo-Song Lee ,  Hyung-Jae Jeong ,  Yong-Dae Park ,  Jong-Min Han ,  Hyoung-Chin Kim ,  Og-Sung Moon ,  Young-Suk Won

IPC分类号： C07D295/10 ,  C07D333/38 ,  C07C229/00

CPC分类号： C07C251/68 ,  C07C251/66 ,  C07D207/335 ,  C07D295/205 ,  C07D307/52 ,  C07D307/68 ,  C07D333/22 ,  C07D333/38

摘要： The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease.The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.

摘要翻译： 本发明涉及新型O-酰氧基肟衍生物，其制备方法以及包含其的用于预防和治疗心血管疾病的药物组合物。 根据本发明的O-酰氧基肟衍生物可以用于预防和治疗由Lp-PLA2引起的高脂血症，冠状动脉心脏病，动脉粥样硬化和心肌梗塞等心血管疾病，因为它们具有优异的Lp- PLA2。

公开(公告)号：US10136663B2

公开(公告)日：2018-11-27

申请号：US14126106

申请日：2012-06-13

申请人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

发明人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

IPC分类号： A61K36/00 ,  A61K36/906 ,  A61K36/28 ,  A23L1/30 ,  A61K31/12 ,  A61K31/704 ,  A61K36/9066 ,  A23K20/111 ,  A23K20/163 ,  A23K50/10 ,  A23K50/75 ,  A23K50/30 ,  A23L33/105 ,  A61K47/69

摘要： The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

公开(公告)号：US20100291248A1

公开(公告)日：2010-11-18

申请号：US12615602

申请日：2009-11-10

申请人： Tae-Sook Jeong ,  Woo Song Lee ,  Ki Hun Park ,  Myung-Sook Choi ,  Ho Yong Park ,  Jong-Min Han ,  Hyung-Jae Jeong

发明人： Tae-Sook Jeong ,  Woo Song Lee ,  Ki Hun Park ,  Myung-Sook Choi ,  Ho Yong Park ,  Jong-Min Han ,  Hyung-Jae Jeong

IPC分类号： A61K36/00

CPC分类号： A61K36/48

摘要： The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of Glycine max leaves or fractions isolated from the same.

摘要翻译： 本发明涉及用于预防和治疗肥胖，高脂血症，动脉粥样硬化，脂肪肝，糖尿病或代谢综合征的组合物，其含有从其分离的大豆叶提取物或其中的级分。

公开(公告)号：US09381222B2

公开(公告)日：2016-07-05

申请号：US12615602

申请日：2009-11-10

申请人： Tae-Sook Jeong ,  Woo Song Lee ,  Ki Hun Park ,  Myung-Sook Choi ,  Ho Yong Park ,  Jong-Min Han ,  Hyung-Jae Jeong

发明人： Tae-Sook Jeong ,  Woo Song Lee ,  Ki Hun Park ,  Myung-Sook Choi ,  Ho Yong Park ,  Jong-Min Han ,  Hyung-Jae Jeong

IPC分类号： A61K36/48

CPC分类号： A61K36/48

摘要： The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of Glycine max leaves or fractions isolated from the same.

摘要翻译： 本发明涉及用于预防和治疗肥胖，高脂血症，动脉粥样硬化，脂肪肝，糖尿病或代谢综合征的组合物，其含有从其分离的大豆叶提取物或其中的级分。

公开(公告)号：US08545903B2

公开(公告)日：2013-10-01

申请号：US13383132

申请日：2010-07-08

申请人： Woo-Song Lee ,  Mun-Chual Rho ,  Su-Jin Park ,  Young-Bae Ryu ,  Jong-Sun Chang ,  Mal-Sun Shin ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

发明人： Woo-Song Lee ,  Mun-Chual Rho ,  Su-Jin Park ,  Young-Bae Ryu ,  Jong-Sun Chang ,  Mal-Sun Shin ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

IPC分类号： A01N65/00

CPC分类号： A61K31/12 ,  A23L27/14 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/9066 ,  A61K2236/30 ,  A23V2200/324 ,  A23V2250/2112

摘要： Disclosed is a composition comprising a turmeric extract for preventing and treating influenza virus infection and for inhibiting neuraminidase activity. A turmeric extract, its fraction, and a curcuminoid-based compound separated therefrom may inhibit neuraminidase activity and have antiviral and cell degeneration inhibitory effects on influenza virus, and may be useful in preventing and treating influenza virus infection.

摘要翻译： 公开了一种组合物，其包含用于预防和治疗流感病毒感染和抑制神经氨酸酶活性的姜黄提取物。 从其分离出的姜黄提取物，其级分和基于姜黄碱的化合物可抑制神经氨酸酶活性并对流感病毒具有抗病毒和细胞变性抑制作用，并且可用于预防和治疗流感病毒感染。

公开(公告)号：US20130041023A1

公开(公告)日：2013-02-14

申请号：US13578528

申请日：2011-02-11

申请人： Woo Song Lee ,  Mun Chual Rho ,  Young Bae Ryu ,  Su Jin Park ,  Jong Sun Chang ,  Hyung Jun Kwon ,  Ha Hyun Kim ,  Hyung Jae Jeong

发明人： Woo Song Lee ,  Mun Chual Rho ,  Young Bae Ryu ,  Su Jin Park ,  Jong Sun Chang ,  Hyung Jun Kwon ,  Ha Hyun Kim ,  Hyung Jae Jeong

IPC分类号： A61K31/353 ,  A61P31/14 ,  A61K31/352 ,  C12N7/06 ,  A61K31/12 ,  A61K31/343

CPC分类号： A61K36/484 ,  A23L7/198 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/085 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K2300/00 ,  A23V2200/324 ,  A23V2250/21 ,  A23V2250/2132

摘要： The present invention relates to a composition for preventing or treating rotavirus infection, comprising a licorice extract, fractions thereof or compounds separated therefrom. The licorice extract, fractions thereof or compounds separated therefrom have anti-rotavirus effects and exhibit not only virucidal effects against various rotaviruses, but also the effect of inhibiting the cytopathic effect of rotaviruses. Thus, the composition can be effectively used for the prevention or treatment of rotavirus infection.

摘要翻译： 本发明涉及一种用于预防或治疗轮状病毒感染的组合物，其包含甘草提取物，其级分或与其分离的化合物。 甘草提取物，其馏分或其分离的化合物具有抗轮状病毒作用，不仅对各种轮状病毒具有杀病毒作用，而且还显示出抑制轮状病毒细胞致病作用的效果。 因此，该组合物可有效地用于预防或治疗轮状病毒感染。

公开(公告)号：US20120107429A1

公开(公告)日：2012-05-03

申请号：US13383132

申请日：2010-07-08

申请人： Woo-Song Lee ,  Mun-Chual Rho ,  Su-Jin Park ,  Young-Bae Ryu ,  Jong-Sun Chang ,  Mal-Sun Shin ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

发明人： Woo-Song Lee ,  Mun-Chual Rho ,  Su-Jin Park ,  Young-Bae Ryu ,  Jong-Sun Chang ,  Mal-Sun Shin ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

IPC分类号： A61K36/9066 ,  C07C49/255 ,  C12N9/99 ,  C07C49/248 ,  C07C45/80 ,  A61P31/16 ,  A61K31/12

CPC分类号： A61K31/12 ,  A23L27/14 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/9066 ,  A61K2236/30 ,  A23V2200/324 ,  A23V2250/2112

摘要： Disclosed is a composition comprising a turmeric extract for preventing and treating influenza virus infection and for inhibiting neuraminidase activity. A turmeric extract, its fraction, and a curcuminoid-based compound separated therefrom may inhibit neuraminidase activity and have antiviral and cell degeneration inhibitory effects on influenza virus, and may be useful in preventing and treating influenza virus infection.

摘要翻译： 公开了一种组合物，其包含用于预防和治疗流感病毒感染和抑制神经氨酸酶活性的姜黄提取物。 从其分离出的姜黄提取物，其级分和基于姜黄碱的化合物可抑制神经氨酸酶活性并对流感病毒具有抗病毒和细胞变性抑制作用，并且可用于预防和治疗流感病毒感染。

公开(公告)号：US07642291B2

公开(公告)日：2010-01-05

申请号：US11163383

申请日：2005-10-17

申请人： Tae-Sook Jeong ,  Woo-Song Lee ,  Hyung-Jae Jeong ,  Yong-Dae Park ,  Jong-Min Han ,  Hyoung-Chin Kim ,  Og-Sung Moon ,  Young-Suk Won

发明人： Tae-Sook Jeong ,  Woo-Song Lee ,  Hyung-Jae Jeong ,  Yong-Dae Park ,  Jong-Min Han ,  Hyoung-Chin Kim ,  Og-Sung Moon ,  Young-Suk Won

IPC分类号： A61K31/15 ,  C07C251/68

CPC分类号： C07C251/68 ,  C07C251/66 ,  C07D207/335 ,  C07D295/205 ,  C07D307/52 ,  C07D307/68 ,  C07D333/22 ,  C07D333/38

摘要： The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.

摘要翻译： 本发明涉及新型O-酰氧基肟衍生物，其制备方法以及包含其的用于预防和治疗心血管疾病的药物组合物。 根据本发明的O-酰氧基肟衍生物可以用于预防和治疗由Lp-PLA2引起的高脂血症，冠状动脉心脏病，动脉粥样硬化和心肌梗塞等心血管疾病，因为它们具有优异的Lp- PLA2。

公开(公告)号：US20140248382A1

公开(公告)日：2014-09-04

申请号：US14126106

申请日：2012-06-13

申请人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

发明人： Woo-Song Lee ,  Young-Bae Ryu ,  Young-Min Kim ,  Su-Jin Park ,  Mun-Chual Rho ,  Hyung-Jae Jeong ,  Hyung-Jun Kwon

IPC分类号： A61K31/704 ,  A23L1/30 ,  A61K36/28 ,  A61K31/12 ,  A61K36/9066

CPC分类号： A61K31/704 ,  A23K20/111 ,  A23K20/163 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A23L33/105 ,  A61K31/12 ,  A61K36/28 ,  A61K36/9066 ,  A61K47/6921 ,  A61K2300/00

摘要： The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

摘要翻译： 本发明涉及包含式（I）化合物或包含该化合物或其部分的植物提取物的复合物; 还包括甜菊糖苷或其一部分的植物提取物，涉及用于预防或治疗包含该复合物作为活性成分的流感病毒感染的药物组合物。 此外，本发明涉及用于预防或改善流感病毒感染的食品组合物，杀病毒准药物组合物，杀病毒饲料添加剂和饲料，其包含该复合物作为活性成分。 根据本发明，包含式（I）化合物或包含该化合物或其部分的植物提取物的复合物; 甜菊糖苷或甜菊糖苷或其部分的植物提取物表现出对特定无病原体（SPF）鸡中的抗病毒效果和抑制细胞降解对流感病毒的抗病毒效果的效果，因此可以有用地 用于预防和治疗流感病毒感染。