专利检索 ap:"INTEGRAL MOLECULAR, INC." 第 1 页

1.

发明公开
ANTIBODIES DIRECTED TO CLAUDIN 6, INCLUDING BISPECIFIC FORMATS THEREOF 审中-公开

公开(公告)号：US20240174751A1

公开(公告)日：2024-05-30

申请号：US18523196

申请日：2023-11-29

申请人： Integral Molecular, Inc.

发明人： Joseph RUCKER , Kyle DOOLAN

IPC分类号： C07K16/28

CPC分类号： C07K16/2809 , C07K16/28 , A61K39/00 , C07K2317/31

摘要： The disclosure is directed to an antibody specific for claudin 6 and CD3 and method of preparing and using the same. The present disclosure describes the isolation and characterization of antibodies, antibody fragments, and antibody variants specific for claudin 6 and CD3.

2.

发明申请
CLAUDIN 6 ANTIBODIES AND USES THEREOF 审中-公开

公开(公告)号：US20200262915A1

公开(公告)日：2020-08-20

申请号：US16790066

申请日：2020-02-13

申请人： Integral Molecular, Inc.

发明人： Ross Chambers , Joseph Rucker , Thomas Charpentier , Lewis J. Stafford , Brad Screnci , Trevor Barnes , Benjamin Doranz

IPC分类号： C07K16/28 , A61K47/68

摘要： Antibodies and compositions against Claudin 6 and uses thereof are provided.

3.

发明申请
Lipoparticles Comprising Proteins, Methods Of Making, And Using The Same 有权
标题翻译：包含蛋白质的脂质体，制备方法和使用它们

公开(公告)号：US20140135230A1

公开(公告)日：2014-05-15

申请号：US14069696

申请日：2013-11-01

申请人： Integral Molecular, Inc.

发明人： Benjamin J. Doranz , Sharon Willis

IPC分类号： G01N33/543

CPC分类号： G01N33/5432 , A61K39/12 , A61K39/245 , A61K39/39 , A61K47/6901 , A61K49/0002 , A61K2039/5258 , A61K2039/55533 , A61K2039/55555 , A61K2039/64 , C07K14/005 , C07K16/2812 , C07K16/2851 , C07K16/2866 , C07K16/32 , C12N2710/10343 , C12N2710/16422 , C12N2710/16434 , C12N2710/24143 , C12N2740/13022 , C12N2760/18522 , C12N2770/36122 , G01N33/569 , G01N33/586 , G01N33/6872 , G01N2333/726 , G01N2500/00

摘要： The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

摘要翻译： 本发明涉及脂质体。本发明还涉及生产脂质体。本发明还涉及包含病毒结构蛋白的脂质体。本发明还涉及包含膜蛋白的脂质体，并且脂质体可以附着到传感器表面。本发明还涉及生产和使用脂质体以特别地评估蛋白质结合相互作用的方法。

4.

发明授权
Glucose transporter 4 antibodies, methods of making the same, and uses thereof 有权

公开(公告)号：US11834497B2

公开(公告)日：2023-12-05

申请号：US17051241

申请日：2019-04-30

申请人： INTEGRAL MOLECULAR, INC.

发明人： David F. Tucker , Kimberly-Anne Mattia , Christine R. Fisher , Benjamin J. Doranz , Joseph B. Rucker

IPC分类号： C07K16/28 , A61P3/10 , C07K14/705 , G01N33/68

CPC分类号： C07K16/28 , A61P3/10 , C07K14/705 , G01N33/6893 , C07K2317/565 , C07K2317/77 , C07K2317/92

摘要： Antibodies and compositions against GLUT4 and uses thereof are provided herein.

5.

发明授权
Claudin 6 antibodies and uses thereof 有权

公开(公告)号：US11248046B2

公开(公告)日：2022-02-15

申请号：US16790066

申请日：2020-02-13

申请人： Integral Molecular, Inc.

发明人： Ross Chambers , Joseph Rucker , Thomas Charpentier , Lewis J. Stafford , Brad Screnci , Trevor Barnes , Benjamin Doranz

IPC分类号： C07K16/28 , A61K47/68

摘要： Antibodies and compositions against Claudin 6 and uses thereof are provided.

6.

发明申请
GLUCOSE TRANSPORTER 4 ANTIBODIES, METHODS OF MAKING THE SAME, AND USES THEREOF 有权

公开(公告)号：US20210238276A1

公开(公告)日：2021-08-05

申请号：US17051241

申请日：2019-04-30

申请人： INTEGRAL MOLECULAR, INC.

发明人： David F. TUCKER , Kimberly-Anne MATTIA , Christine R. FISHER , Benjamin J. DORANZ , Joseph B. RUCKER

IPC分类号： C07K16/28 , G01N33/68 , C07K14/705 , A61P3/10

摘要： Antibodies and compositions against GLUT4 and uses thereof are provided herein.

7.

发明申请
CLAUDIN 6 ANTIBODIES AND USES THEREOF 有权

公开(公告)号：US20220127355A1

公开(公告)日：2022-04-28

申请号：US17568438

申请日：2022-01-04

申请人： Integral Molecular, Inc.

发明人： Ross CHAMBERS , Joseph RUCKER , Thomas CHARPENTIER , Lewis J. STAFFORD , Brad SCRENCI , Trevor BARNES , Benjamin DORANZ

IPC分类号： C07K16/28 , A61K47/68

摘要： Antibodies and compositions against Claudin 6 and uses thereof are provided.

8.

发明授权
Modified ebolavirus glycoproteins comprising mutations in the head and base domains that increase antibody cross-reactivity 有权

公开(公告)号：US11135280B2

公开(公告)日：2021-10-05

申请号：US16084151

申请日：2017-03-27

申请人： INTEGRATED BIOTHERAPEUTICS, INC. , INTEGRAL MOLECULAR, INC.

发明人： Mohammad Javad Aman , Katie A. Howell , Edgar Davidson , Benjamin J. Doranz

IPC分类号： A61K39/12 , C07K14/005 , C12N15/86

摘要： Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.

9.

发明申请
ANTIBODIES COMPRISING A COMMON LIGHT CHAIN AND USES THEREOF 审中-公开

公开(公告)号：US20200262898A1

公开(公告)日：2020-08-20

申请号：US16789626

申请日：2020-02-13

申请人： Integral Molecular, Inc.

发明人： Thomas Charpentier , Ross Chambers , Lewis J. Stafford , Trevor Barnes , Jonathan T. Sullivan

IPC分类号： C07K16/18

摘要： Peptides and uses thereof, such as a common light chain in an antibody, are provided.

10.

发明授权
Antibodies directed to claudin 6, including bispecific formats thereof 有权

公开(公告)号：US12049502B2

公开(公告)日：2024-07-30

申请号：US18523196

申请日：2023-11-29

申请人： Integral Molecular, Inc.

发明人： Joseph Rucker , Kyle Doolan

IPC分类号： C07K16/28 , A61K39/00

CPC分类号： C07K16/2809 , C07K16/28 , A61K39/00 , C07K2317/31

摘要： The disclosure is directed to an antibody specific for claudin 6 and CD3 and method of preparing and using the same. The present disclosure describes the isolation and characterization of antibodies, antibody fragments, and antibody variants specific for claudin 6 and CD3.

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