公开(公告)号：US20180069368A1

公开(公告)日：2018-03-08

申请号：US15695594

申请日：2017-09-05

Applicant: INTER-UNIVERSITY RESEARCH INSTITUTE CORP. NATIONAL INSTITUTES OF NATURAL SCIENCES

Inventor： Takunori TAIRA ,  Vincent YAHIA

IPC: H01S3/08 ,  H01S3/06 ,  H01S5/00

CPC classification number: H01S3/08018 ,  H01S3/005 ,  H01S3/0071 ,  H01S3/0602 ,  H01S3/0612 ,  H01S3/0621 ,  H01S3/0623 ,  H01S3/0627 ,  H01S3/0804 ,  H01S3/08059 ,  H01S3/094053 ,  H01S3/09415 ,  H01S3/10007 ,  H01S3/113 ,  H01S3/2308 ,  H01S3/2316 ,  H01S3/2333 ,  H01S5/005 ,  H01S2301/20

Abstract: Both of multi-mode laser beam 8A and excitation beam 34A for amplification are imputed to an amplification gain medium 62 in a relationship in which their optical axes match each other and an effective beam diameter of the excitation beam for amplification is smaller than an effective beam diameter of the multi-mode laser beam. As a result, laser beam of a part of modes progressing in a radiation range of the excitation beam 34A for amplification is selectively amplified. Laser beam 40A subjected to mode cleaning is thereby outputted.

公开(公告)号：US11976062B2

公开(公告)日：2024-05-07

申请号：US18073180

申请日：2022-12-01

Applicant: OSAKA UNIVERSITY ,  KYOTO UNIVERSITY ,  INTER-UNIVERSITY RESEARCH INSTITUTE CORP NATIONAL INSTITUTES OF NATURAL SCIENCES

Inventor： Ryu Nagata ,  Yasuo Mori ,  Masayuki Mori ,  Motohiro Nishida ,  Takuro Tomita

IPC: C07D413/12 ,  A61P43/00 ,  C07D261/20 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/08

CPC classification number: C07D413/12 ,  A61P43/00 ,  C07D261/20 ,  C07D413/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/08

Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1)




(wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).

公开(公告)号：US10056730B2

公开(公告)日：2018-08-21

申请号：US15695594

申请日：2017-09-05

Applicant: INTER-UNIVERSITY RESEARCH INSTITUTE CORP. NATIONAL INSTITUTES OF NATURAL SCIENCES

Inventor： Takunori Taira ,  Vincent Yahia

IPC: H01S3/08 ,  H01S3/06 ,  H01S5/00

Abstract: Both of multi-mode laser beam 8A and excitation beam 34A for amplification are imputed to an amplification gain medium 62 in a relationship in which their optical axes match each other and an effective beam diameter of the excitation beam for amplification is smaller than an effective beam diameter of the multi-mode laser beam. As a result, laser beam of a part of modes progressing in a radiation range of the excitation beam 34A for amplification is selectively amplified. Laser beam 40A subjected to mode cleaning is thereby outputted.