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公开(公告)号:US11642374B2
公开(公告)日:2023-05-09
申请号:US16182146
申请日:2018-11-06
申请人: REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人: Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号: A61P35/00 , A61K35/17 , A61K48/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
CPC分类号: A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号:US20220105133A1
公开(公告)日:2022-04-07
申请号:US17481404
申请日:2021-09-22
申请人: Regents of the University of Minnesota , Intima Bioscience, Inc. , The U.S.A., as Represented by the Secretary, Department of Health and Human Service
发明人: Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号: A61K35/17 , C12N15/113 , C07K14/705 , C07K14/47 , A61P31/00 , A61P35/00 , A61K9/00 , C07K14/725 , C07K14/715 , C12N5/0783 , C12N9/22 , C12N15/79 , C12N15/90
摘要: Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.
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公开(公告)号:US20210024924A1
公开(公告)日:2021-01-28
申请号:US16809343
申请日:2020-03-04
发明人: Lei S. Qi , Modassir S. Choudhry , Xueqiu Lin , Xiaoshu Xu
IPC分类号: C12N15/113
摘要: Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.
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公开(公告)号:US11925664B2
公开(公告)日:2024-03-12
申请号:US16900368
申请日:2020-06-12
申请人: Regents of the University of Minnesota , Intima Bioscience, Inc. , The U.S.A., as Represented by the Secretary, Department of Health and Human Services
IPC分类号: A61K48/00 , A61K35/17 , C07K14/47 , C07K14/705 , C07K14/715 , C07K14/725 , C12N5/0783 , C12N9/22 , C12N9/96 , C12N15/07 , C12N15/113 , C12N15/90 , C12N15/87
CPC分类号: A61K35/17 , C07K14/4718 , C07K14/70503 , C07K14/7051 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号:US11903966B2
公开(公告)日:2024-02-20
申请号:US16180867
申请日:2018-11-05
申请人: REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The U.S.A. as represented by the Secretary, Department of Health and Human Services
发明人: Branden Moriarity , Beau Webber , Modassir Choudhry , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号: C12N15/00 , A61K35/17 , A61P35/00 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96 , C12N15/87
CPC分类号: A61K35/17 , C07K14/4718 , C07K14/7051 , C07K14/70503 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/907 , C12N15/87 , C12N2310/20 , C12N2510/00
摘要: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号:US20230227778A1
公开(公告)日:2023-07-20
申请号:US18048227
申请日:2022-10-20
发明人: Thomas HENLEY , Modassir CHOUDHRY
IPC分类号: C12N5/0783
CPC分类号: C12N5/0636 , C12N2502/1121 , C12N2501/2301 , C12N2501/2302 , C12N2501/2304 , C12N2501/2307 , C12N2501/2315 , C12N2501/25 , C12N2501/26 , C12N2501/22 , C12N2501/998
摘要: Provided herein are compositions and methods for use in generating an immune response against a target peptide antigen. Also included, are methods for stabilizing, treating, and eliminating various diseases and conditions associated with target peptide expression.
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公开(公告)号:US20220125843A1
公开(公告)日:2022-04-28
申请号:US17478615
申请日:2021-09-17
申请人: Regents of the University of Minnesota , Intima Bioscience, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Servic
发明人: Branden Moriarity , Beau Webber , Modassir Choudhry , R. Scott McIvor , David Largaespada , Steven A. Rosenberg , Douglas C. Palmer , Nicholas P. Restifo
IPC分类号: A61K35/17 , C07K14/47 , C12N9/22 , C12N9/96 , C07K14/725 , C12N15/90 , C07K14/715 , C12N15/113 , C07K14/705 , C12N5/0783 , C12N15/87
摘要: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号:US20220064668A1
公开(公告)日:2022-03-03
申请号:US17365026
申请日:2021-07-01
发明人: Modassir CHOUDHRY , Mavis AGBANDJE-MCKENNA , Tilmann BUERCKSTUEMMER , Thomas HENLEY , Lydia VINEY
IPC分类号: C12N15/86
摘要: Adeno-associated virus has numerous advantages for its use in gene therapy. The present disclosures provide genetically modified adeno-associated viral vectors, and the methods of making the genetically modified adeno-associated viral vectors and compositions in treating cancer, other conditions, diseases, and disorders.
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公开(公告)号:US20170130200A1
公开(公告)日:2017-05-11
申请号:US15224151
申请日:2016-07-29
IPC分类号: C12N5/0783 , A61K35/17 , C07K14/705 , C07K14/725 , C12N15/90 , C07K14/47
CPC分类号: A61K35/17 , C07K14/4718 , C07K14/70503 , C07K14/7051 , C07K14/70521 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87 , C12N15/907 , C12N2310/20 , C12N2510/00 , C12N2800/80 , Y02A50/463
摘要: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号:US20170065636A1
公开(公告)日:2017-03-09
申请号:US15250514
申请日:2016-08-29
IPC分类号: A61K35/17 , C07K14/47 , C07K14/725 , C12N5/0783
CPC分类号: A61K35/17 , C07K14/4718 , C07K14/70503 , C07K14/7051 , C07K14/70521 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87 , C12N15/907 , C12N2310/20 , C12N2510/00 , C12N2800/80 , Y02A50/463
摘要: Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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