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    Circular dumbbell decoy oligodeoxynucleotides (CDODN) containing DNA bindings sites of transcription
    1.
    发明授权
    Circular dumbbell decoy oligodeoxynucleotides (CDODN) containing DNA bindings sites of transcription 有权
    圆形哑铃诱饵寡脱氧核苷酸（CDODN）含有DNA结合位点的转录

    公开(公告)号：US08647820B2

    公开(公告)日：2014-02-11

    申请号：US13036578

    申请日：2011-02-28

    申请人： In-Kyu Lee ,  Ryuichi Morishita

    发明人： In-Kyu Lee ,  Ryuichi Morishita

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04 ,  A61K38/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/13 ,  C12N2310/53

    摘要： The present invention provides a circular dumbbell oligodeoxynucleotide (CDODN) comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of a transcriptional factor. The present invention further provides a pharmaceutical composition comprising said CDODN. The pharmaceutical composition can be used for treating and/or preventing a disease or disorder related to such a transcriptional factor. The present invention also provides a method for treating and/or preventing a disease or disorder related to such a transcriptional factor, comprising administering to the subject a therapeutically effective amount of a CDODN comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of the transcriptional factor.

    摘要翻译： 本发明提供了包含两个环结构和茎结构的环状哑铃寡脱氧核苷酸（CDODN），其中所述茎结构包含能够结合转录因子的DNA结合结构域的核苷酸序列。 本发明还提供了包含所述CDODN的药物组合物。 药物组合物可用于治疗和/或预防与这种转录因子相关的疾病或病症。 本发明还提供了用于治疗和/或预防与这种转录因子相关的疾病或病症的方法，包括向受试者施用治疗有效量的包含两个环结构和茎结构的CDODN，其中茎结构包括 能够结合转录因子的DNA结合结构域的核苷酸序列。

    Apparatus and method for selecting antenna in an orthogonalized spatial multiplexing system
    2.
    发明授权
    Apparatus and method for selecting antenna in an orthogonalized spatial multiplexing system 有权
    在正交空间复用系统中选择天线的装置和方法

    公开(公告)号：US08155231B2

    公开(公告)日：2012-04-10

    申请号：US11850301

    申请日：2007-09-05

    申请人： Kyung-Hun Jang ,  In-Kyu Lee ,  Dong-Jun Lee ,  Heun-Chul Lee ,  Jung-Hoon Suh ,  Young-Soo Kim ,  Hyo-Sun Hwang

    发明人： Kyung-Hun Jang ,  In-Kyu Lee ,  Dong-Jun Lee ,  Heun-Chul Lee ,  Jung-Hoon Suh ,  Young-Soo Kim ,  Hyo-Sun Hwang

    IPC分类号： H04B7/02

    CPC分类号： H04B7/0691 ,  H04B7/061 ,  H04B7/0697 ,  H04L1/0054

    摘要： A method for selecting an antenna in an orthogonalized spatial multiplexing system. Upon receipt of at least one symbol from a transmitter via multiple receive antennas, a receiver decodes each of the received symbols; determines a rotation angle between the received symbols, and selects an optimal subset of transmit antennas using a distance between vectors of the decoded symbols; generates feedback information including the determined rotation angle and the selected optimal subset, and transmits the generated feedback information to the transmitter. Upon receipt of the feedback information, the transmitter beam-forms an antenna corresponding to the optimal subset depending on the received feedback information, and transmits a data symbol to the receiver. The receiver detects each of data symbols received from the transmitter.

    摘要翻译： 一种在正交空间复用系统中选择天线的方法。 在经由多个接收天线从发射机接收到至少一个符号后，接收机对每个所接收的符号进行解码; 确定接收到的符号之间的旋转角度，并使用解码符号的向量之间的距离来选择发射天线的最佳子集; 产生包括所确定的旋转角度和所选择的最佳子集的反馈信息，并将生成的反馈信息发送到发射机。 在接收到反馈信息时，发射机波束根据接收的反馈信息形成对应于最佳子集的天线，并将数据符号发送到接收机。 接收机检测从发射机接收的每个数据符号。

    NOVEL USE OF DIMETHYLFUMARATE
    3.
    发明申请
    NOVEL USE OF DIMETHYLFUMARATE 审中-公开
    二甲基丙酸的新用途

    公开(公告)号：US20100324327A1

    公开(公告)日：2010-12-23

    申请号：US12677089

    申请日：2008-09-10

    申请人： In Kyu Lee

    发明人： In Kyu Lee

    IPC分类号： C07C69/60

    CPC分类号： A61K31/225

    摘要： Disclosed are a pharmaceutical composition for inhibiting vascular smooth muscle cell proliferation comprising dimethyl fumarate as an effective ingredient, use of dimethyl fumarate for inhibiting vascular smooth muscle cell proliferation, and a method of inhibiting vascular smooth muscle cell proliferation employing the same. Through the present invention, it was found that dimethyl fumarate could inhibit vascular smooth muscle cell proliferation by increasing the activity of AMPK. Accordingly, dimethyl fumarate can be usefully used as an effective ingredient of a medicine for inhibiting vascular smooth muscle cell proliferation.

    摘要翻译： 公开了一种用于抑制血管平滑肌细胞增殖的药物组合物，其包含富马酸二甲酯作为有效成分，使用富马酸二甲酯抑制血管平滑肌细胞增殖，以及使用该药物组合物抑制血管平滑肌细胞增殖的方法。 通过本发明，通过增加AMPK的活性，发现富马酸二甲酯可以抑制血管平滑肌细胞增殖。 因此，富马酸二甲酯可有效地用作抑制血管平滑肌细胞增殖的药物的有效成分。

    Processes for the preparation of cephalosporin derivatives
    4.
    发明授权
    Processes for the preparation of cephalosporin derivatives 有权
    制备头孢菌素衍生物的方法

    公开(公告)号：US07622577B2

    公开(公告)日：2009-11-24

    申请号：US10577551

    申请日：2004-10-30

    申请人： Dae Won Seo ,  In Hwa Chung ,  Ki Bong Lee ,  In Kyu Lee

    发明人： Dae Won Seo ,  In Hwa Chung ,  Ki Bong Lee ,  In Kyu Lee

    IPC分类号： C07D501/22

    CPC分类号： C07D501/00 ,  Y02P20/55

    摘要： Provided is a process for preparing a compound of formula 1 or its salt, which comprises reacting a compound represented by the following formula 4 with acetaldehyde in a mixed solvent comprising water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the presence of a first base to stereospecifically prepare a compound represented by the following formula 3′; and reacting the compound of the formula 3′ with an anhydrous compound represented by the following formula 2 in the presence of a second base: wherein R1 is a hydrogen or an amino protecting group, R2 is a hydrogen or a carboxyl protecting group, and R3 is a hydrogen or an amino protecting group consisting of phenylacetyl group, wherein when R3 is a phenylacetyl group, R2 is not a hydrogen in formula 3′; and wherein, when at least one of R2 and R3 is a protecting group, all such protecting groups are removed from formula 3′, thereby producing a compound represented by formula 6 prior to reacting it with the compound of formula 2.

    摘要翻译： 本发明提供制备式1化合物或其盐的方法，该方法包括使下式4表示的化合物与乙醛在含有水，异丙醇和二氯甲烷的混合溶剂中以体积比为1:3-6:3的比例反应， 11-14在第一碱的存在下，立体选择性地制备由下式3'表示的化合物; 并使式3'化合物与下式2表示的无水化合物在第二碱存在下反应：其中R1是氢或氨基保护基，R2是氢或羧基保护基，R3是 是由苯乙酰基组成的氢或氨基保护基，其中当R3是苯乙酰基时，R2不是式3'中的氢; 并且其中当R 2和R 3中的至少一个是保护基时，从式3'中除去所有这些保护基，从而在与式2化合物反应之前制备由式6表示的化合物。

    Dispenser system for liquid crystal display panel and dispensing method using the same
    6.
    发明授权
    Dispenser system for liquid crystal display panel and dispensing method using the same 有权
    液晶显示面板分配器系统及使用其的分配方法

    公开(公告)号：US07345734B2

    公开(公告)日：2008-03-18

    申请号：US10825244

    申请日：2004-04-16

    申请人： In-Kyu Lee

    发明人： In-Kyu Lee

    IPC分类号： G02F1/1339

    CPC分类号： G02F1/1339 ,  G02F1/133351

    摘要： A dispenser system for a liquid crystal display panel includes a table, a rotatable plate on the table, a substrate disposed on the plate, the substrate having a plurality of first image display parts and a plurality of second image display parts, and at least one syringe supplying a sealant material onto the substrate to sequentially form a plurality of first seal patterns and a plurality of second seal patterns, wherein each of the plurality of first seal patterns are formed along outer edge portions of the first image display parts and each of the plurality of second seal patterns are formed along outer edge portions of the second image display parts.

    摘要翻译： 一种用于液晶显示面板的分配器系统，包括桌子，桌子上的可旋转板，设置在板上的衬底，衬底具有多个第一图像显示部分和多个第二图像显示部分，以及至少一个 注射器将密封剂材料供应到基板上以顺序地形成多个第一密封图案和多个第二密封图案，其中多个第一密封图案中的每一个沿着第一图像显示部件的外边缘部分形成， 沿着第二图像显示部件的外边缘部分形成多个第二密封图案。

    Apparatus and method for determining optimum integer perturbation vector of low complexity in multiple antenna system
    8.
    发明授权
    Apparatus and method for determining optimum integer perturbation vector of low complexity in multiple antenna system 有权
    用于确定多天线系统中低复杂度的最优整数扰动矢量的装置和方法

    公开(公告)号：US08358718B2

    公开(公告)日：2013-01-22

    申请号：US12798185

    申请日：2010-03-30

    申请人： Sung-Ho Lee ,  Keun-Chul Hwang ,  Soon-Young Yoon ,  In-Kyu Lee ,  Seok-Hwan Park

    发明人： Sung-Ho Lee ,  Keun-Chul Hwang ,  Soon-Young Yoon ,  In-Kyu Lee ,  Seok-Hwan Park

    IPC分类号： H04L27/00

    CPC分类号： H04B7/0452 ,  H04B7/0456 ,  H04J11/0033 ,  H04L25/0204 ,  H04L25/0244 ,  H04L25/03343

    摘要： An apparatus and a method for determining an optimum integer perturbation vector of a low complexity in a multiple antenna system include a transmitter that transmits data using an optimum integer perturbation vector of a low complexity in a multiple antenna system includes a module pre-processor, a shift pre-processor, and a precoder. The modulo pre-processor adds an integer perturbation vector to a transmission signal vector. The shift pre-processor phase-shifts a pseudo inverse matrix of a channel matrix using a phase angle. The precoder precodes a transmission signal vector perturbed by the integer perturbation vector using the phase-shifted pseudo inverse matrix of the channel matrix.

    摘要翻译： 用于确定多天线系统中的低复杂度的最佳整数扰动矢量的装置和方法包括使用多天线系统中的低复杂度的最佳整数扰动向量来发射数据的发射机，包括模块预处理器， 移位预处理器和预编码器。 模数预处理器将一个整数扰动矢量加到传输信号矢量上。 移位预处理器使用相位角相移一个信道矩阵的伪逆矩阵。 预编码器使用信道矩阵的相移伪逆矩阵来预处理由整数扰动向量扰动的传输信号向量。

    NOVEL USE OF DIMETHYLFUMARATE
    9.
    发明申请
    NOVEL USE OF DIMETHYLFUMARATE 审中-公开
    二甲基丙酸的新用途

    公开(公告)号：US20120232142A1

    公开(公告)日：2012-09-13

    申请号：US13410020

    申请日：2012-03-01

    申请人： In Kyu LEE

    发明人： In Kyu LEE

    IPC分类号： A61K31/225

    CPC分类号： A61K31/225

    摘要： Disclosed are a pharmaceutical composition for inhibiting vascular smooth muscle cell proliferation comprising dimethyl fumarate as an effective ingredient, use of dimethyl fumarate for inhibiting vascular smooth muscle cell proliferation, and a method of inhibiting vascular smooth muscle cell proliferation employing the same. Through the present invention, it was found that dimethyl fumarate could inhibit vascular smooth muscle cell proliferation by increasing the activity of AMPK. Accordingly, dimethyl fumarate can be usefully used as an effective ingredient of a medicine for inhibiting vascular smooth muscle cell proliferation.

    摘要翻译： 公开了一种用于抑制血管平滑肌细胞增殖的药物组合物，其包含富马酸二甲酯作为有效成分，使用富马酸二甲酯抑制血管平滑肌细胞增殖，以及使用该药物组合物抑制血管平滑肌细胞增殖的方法。 通过本发明，通过增加AMPK的活性，发现富马酸二甲酯可以抑制血管平滑肌细胞增殖。 因此，富马酸二甲酯可有效地用作抑制血管平滑肌细胞增殖的药物的有效成分。