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    Excitatory amino acid receptor modulators
    2.
    发明授权
    Excitatory amino acid receptor modulators 失效
    兴奋性氨基酸受体调节剂

    公开(公告)号：US07081481B2

    公开(公告)日：2006-07-25

    申请号：US10276532

    申请日：2001-05-24

    申请人： Ivan Collado-Cano ,  Maria Rosario Gonzalez-Garcia ,  Beatriz López De Uralde-Garmendia

    发明人： Ivan Collado-Cano ,  Maria Rosario Gonzalez-Garcia ,  Beatriz López De Uralde-Garmendia

    IPC分类号： A61K31/197 ,  C07C229/28

    CPC分类号： C07C271/30 ,  C07B2200/07 ,  C07C229/46 ,  C07C271/22 ,  C07C271/24 ,  C07C271/28 ,  C07C275/18 ,  C07C275/24 ,  C07C275/28 ,  C07C311/19 ,  C07C335/16 ,  C07C2601/02 ,  C07C2601/14

    摘要： Compounds of the formula (I) in which: R1 is (CH2)nY; n is 1 or 2; Y is NHSO2R2 or X1—W—X2—R3; X1 is O or NH; W is C═O, C═S, C═NH, or SO2; X2 is O or NH, provided that X1 and X2 are not both O; R2 is C1-10 alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10alkynyl; C3-8 cycloalkyl or C3-8-cycloalkyl-C1-10 alkyl; and R3 is hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkynyl; aryl; aryl-C1-10 alkyl; aryl-C2-10 alkenyl; aryl-C2-10 alkynyl; C3-8 cycloalkyl; or C3-8-cycloalkyl-C1-10 alkyl; or a salt or ester thereof, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.

    摘要翻译： 式（I）的化合物，其中：R 1是（CH 2）n Y; n为1或2; Y是NHSO 2 R 2或X 1 -WX 2 - 3 - 3 ; X 1是O或NH; W是C-O，C-S，C-NH或SO 2。 X 2是O或NH，条件是X 1和X 2都不是O; R 2是C 1-10烷基; C 2-10链烯基; C 2-10炔基; 芳基; 芳基-C 1-10烷基; 芳基-C 2-10链烯基; 芳基-C 2-10炔基; C 3-8环烷基或C 3-8 - 环烷基-C 1-10烷基; R 3是氢，C 1-10烷基; C 2-10链烯基; C 2-10炔基; 芳基; 芳基-C 1-10烷基; 芳基-C 2-10链烯基; 芳基-C 2-10炔基; C 3-8环烷基; 或C 3-8 - 环烷基-C 1-10烷基; 或其盐或酯调节代谢型谷氨酸受体功能，并且可用于治疗中枢神经系统疾病。

    Compounds with pharmaceutical properties
    10.
    发明授权
    Compounds with pharmaceutical properties 失效
    具有药物性质的化合物

    公开(公告)号：US06172058B2

    公开(公告)日：2001-01-09

    申请号：US09054874

    申请日：1998-04-03

    申请人： Concepci{acute over (o)}n Pedregal Tercero ,  Ivan Collado Cano ,  Angel Maz{acute over (o)}n Ruiz

    发明人： Concepci{acute over (o)}n Pedregal Tercero ,  Ivan Collado Cano ,  Angel Maz{acute over (o)}n Ruiz

    IPC分类号： C07C22928

    CPC分类号： C07C229/28 ,  C07C2601/02 ,  C07D233/78 ,  C07D241/08 ,  Y02P20/55

    摘要： A pharmaceutical compound of the formula in which R1 is C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-10 alkyl, C3-10 cycloalkyl-C2-10 alkenyl, C3-10 cycloalky-C2-10 alkynyl, optionally substituted phenyl-C1-10 alkyl, optionally substituted phenyl-C2-10 alkenyl, optionally substituted phenyl-C2-10 alkynyl, optionally substituted naphthyl, optionally substituted naphthyl-C1-10 alkyl, C1-10 alkoxy-C1-10 alkyl, C3-10 cycloalkoxy-C1-10 alkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyl-C1-10 alkyl, optionally substituted phenyl fused to C5-10 cycloalkyl, optionally substituted tricyclic, optionally substituted tricyclic-C1-10 alkyl, or [optionally substituted phenyl(CH2)n]2-C1-10 alkyl, where n is 0 or 1 to 4, and R2 is hydrogen or one of the values for R1; or a salt or ester thereof.

    摘要翻译： R1为C1-10烷基，C2-10烯基，C2-10炔基，C3-10环烷基，C3-10环烷基-C10-10烷基，C3-10环烷基-C2-10烯基，C3 -10环烷基-C2-10炔基，任选取代的苯基-C 1-10烷基，任选取代的苯基-C 2-10烯基，任选取代的苯基-C 2-10炔基，任选取代的萘基，任选取代的萘基-C 1-10烷基，C 1 C10烷氧基-C 1-10烷基，C 3-10环烷氧基-C 1-10烷基，任选取代的杂环基，任选取代的杂环基-C 1-10烷基，任选取代的与C 5-10环烷基稠合的苯基，任选取代的三环，任选取代的三环 - C 1-10烷基或[任选取代的苯基（CH 2）n] 2 -C 1-10烷基，其中n为0或1至4，并且R 2为氢或R 1的值之一; 或其盐或酯。