公开(公告)号：US4999493A

公开(公告)日：1991-03-12

申请号：US514658

申请日：1990-04-24

申请人： Mark Allen ,  Ivor A. S. Lewis

发明人： Mark Allen ,  Ivor A. S. Lewis

IPC分类号： G01N30/72 ,  H01J49/04

CPC分类号： H01J49/165 ,  G01N30/7266 ,  G01N30/7273 ,  H01J49/044 ,  H01J49/0486

摘要： Improved techniques are provided for forming ionized molecules from electrosprayed droplets for analysis by a mass spectrometer. A high voltage is applied to a capillary tube for spraying droplets at substantially atmospheric pressure or above, and the electrosprayed droplets contain sample solute of interest and solvent. The electrosprayed droplets are passed into an ion generating chamber which is maintained at a pressure in the range of from 0.2 Torr to 10 Torr. The walls of the ion generating chamber are controllably heated to a temperature which will desolvate the droplets and produce ionized molecules of interest for analysis by the mass spectrometer. The electrospray technique does not rely upon a countercurrent heated gas flow, and provides a particularly simple and inexpensive means to couple electrospray ionization to either quadrupole or magnetic mass analyzers.

摘要翻译： 提供了用于从电喷雾液滴形成离子化分子以进行质谱分析的改进技术。 将高电压施加到用于在基本上大气压以上喷雾液滴的毛细管，并且电喷雾的液滴含有目标溶剂和溶剂。 电喷雾的液滴进入离子产生室，其保持在0.2托至10托的压力范围内。 离子发生室的壁被可控地加热到将使液滴脱溶质并产生离子化分子的温度，由质谱仪分析。 电喷雾技术不依赖于逆流加热的气流，并且提供了将电喷雾离子化耦合到四极杆或磁性质量分析器的特别简单和便宜的手段。

公开(公告)号：US4647772A

公开(公告)日：1987-03-03

申请号：US704283

申请日：1985-02-22

申请人： Ivor A. S. Lewis ,  David C. Smith

发明人： Ivor A. S. Lewis ,  David C. Smith

IPC分类号： G01N30/72 ,  H01J49/04

CPC分类号： H01J49/0431 ,  G01N30/7253 ,  H01J49/0468

摘要： A mass spectrometer having a thermospray ion source, suitable for the analysis of liquid samples is disclosed. The source comprises a strongly heated atomizing nozzle (4) through which the sample is pumped into a spray chamber (5, 11), and an aperture in a cone (26), through which the ions pass through an electrostatic lens (15, 16, 17) into a region (23) in which a mass analyzer is situated. Electrode means (27, 45) generate a repulsive electrostatic field which improves the efficiency of the transmission of ions through the hole in the cone (26). The electrode is situated downstream of the hole in cone (26). By further increasing the potential on the electrode (27, 45) the nature of the ions passing through the hole in the cone (26) can be changed from largely adduct and cluster ions formed by association of solvent molecules with sample ions in the thermospray to largely pseudomolecular sample ions similar to those formed by conventional chemical ionization.

摘要翻译： 公开了一种具有适用于液体样品分析的热喷射离子源的质谱仪。 源包括强烈加热的雾化喷嘴（4），样品通过该雾化喷嘴泵送到喷雾室（5,11）中，以及锥体（26）中的孔，离子通过该孔通过静电透镜（15,16） ，17）进入质量分析器所在的区域（23）中。 电极装置（27,45）产生排斥静电场，这提高离子通过锥体（26）中的孔的透射效率。 电极位于锥体（26）中的孔的下游。 通过进一步增加电极（27,45）上的电位，通过锥体（26）中的孔的离子的性质可以通过在热喷涂中与溶剂分子与样品离子缔合形成的大量加合物和簇离子而变化 大部分假分子样品离子与常规化学电离形成的离子类似。