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公开(公告)号：US20230302203A1
公开(公告)日：2023-09-28
申请号：US18007218
申请日：2021-07-30
CPC分类号： A61L27/52 , A61L27/025 , A61L27/16 , A61F2/12 , A61L2400/12 , A61L2430/04 , A61L2430/34
摘要： An implant capable of maintaining, even when being implanted in a body for a long period of time, desirable mechanical properties, non-bioabsorbable properties, and/or biocompatibility is provided. The implant contains a nanocomposite hydrogel obtained through formation of an organic-inorganic network structure in which an amide group-containing polymer compound and an inorganic clay nano-sheet are linked.
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公开(公告)号：US20230074443A1
公开(公告)日：2023-03-09
申请号：US17800307
申请日：2020-10-29
发明人： SHOJIRO KATOH , Samuel JK ABRAHAM
摘要： The purpose of the present invention is to provide (i) a method for maintaining or enhancing the activity of a cell mass separated from an epithelial tissue; (ii) a method for increasing the proliferation ability of cells in an epithelial tissue; (iii) a method for producing a cell mass employing these methods; (iv) a pharmaceutical composition containing the cell mass; and, (v) a method for treating a disease using the cell mass. The purpose is fulfilled by culturing a cell mass separated from an epithelial tissue or an epithelial tissue with a thermoreversible polymer.
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公开(公告)号：US20230365934A1
公开(公告)日：2023-11-16
申请号：US18027892
申请日：2021-09-22
IPC分类号： C12N5/077
CPC分类号： C12N5/0655 , C12N2533/30
摘要： A first method is provided for increasing the tissue regeneration capacity of a cell population, a cell population production method that includes the first method, and a cell population produced using the production method. The methods for increasing the tissue regeneration capacity of a cell population can include, for example, a step for incubating a cell population in a gel-like thermoreversible polymer solution.
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公开(公告)号：US20230092155A1
公开(公告)日：2023-03-23
申请号：US17601861
申请日：2020-04-08
发明人： SHOJIRO KATOH , SAMUEL JK ABRAHAM , SUNAO KUBOTA
摘要： The purpose of the present invention is to provide a chondrocyte culture with high tissue regeneration ability. This purpose is met by a method involving a step in which a cell population separated from cartilage tissue is cultured on a thermoreversible polymer.
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公开(公告)号：US20230089316A1
公开(公告)日：2023-03-23
申请号：US17801102
申请日：2021-02-19
发明人： SHOJIRO KATOH , SAMUEL JK ABRAHAM
IPC分类号： A01N1/02
摘要： A biomaterial preserving composition including a thermos-reversible polymer is provided. The composition is capable of solving problems related to conventional biomaterial preserving liquids not being sufficient for the survival or functional retention of cells in a biomaterial, and having many restrictions in preservation conditions such as the preservation temperature and the preservation treatment, resulting in a bottleneck for widespread use of cell therapy.
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公开(公告)号：US20200330375A1
公开(公告)日：2020-10-22
申请号：US16753592
申请日：2018-10-01
摘要： [Object]The present invention is intended to provide a urethral stricture treatment agent and a urethral stricture treatment method capable of avoiding restenosis by a less invasive transurethral endoscopic procedure in urethral stricture treatment.[Solution]A urethral stricture treatment agent including at least a hydrogel-forming polymer, and having a storage elastic modulus of 50 Pa or less at 10° C. and a storage elastic modulus of 100 Pa or more at 37° C.A urethral stricture treatment method at least including injecting the urethral stricture treatment agent cooled to 10° C. or lower into an inner surface of urethra which has been incised with a transurethral endoscopic procedure, and holding the urethral stricture treatment agent in the inner surface of urethra at a temperature not lower than a room temperature.
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