公开(公告)号：US20230302203A1

公开(公告)日：2023-09-28

申请号：US18007218

申请日：2021-07-30

申请人： JBM Incorporation ,  GN Corporation Co Ltd

发明人： Samuel JK ABRAHAM ,  Kazutoshi HARAGUCHI

IPC分类号： A61L27/52 ,  A61L27/02 ,  A61L27/16 ,  A61F2/12

CPC分类号： A61L27/52 ,  A61L27/025 ,  A61L27/16 ,  A61F2/12 ,  A61L2400/12 ,  A61L2430/04 ,  A61L2430/34

摘要： An implant capable of maintaining, even when being implanted in a body for a long period of time, desirable mechanical properties, non-bioabsorbable properties, and/or biocompatibility is provided. The implant contains a nanocomposite hydrogel obtained through formation of an organic-inorganic network structure in which an amide group-containing polymer compound and an inorganic clay nano-sheet are linked.

公开(公告)号：US20230074443A1

公开(公告)日：2023-03-09

申请号：US17800307

申请日：2020-10-29

申请人： JBM INCORPORATION ,  GN Corporation Co Ltd

发明人： SHOJIRO KATOH ,  Samuel JK ABRAHAM

IPC分类号： A61K35/38 ,  C12N5/071 ,  A61K38/30 ,  A61P13/02

摘要： The purpose of the present invention is to provide (i) a method for maintaining or enhancing the activity of a cell mass separated from an epithelial tissue; (ii) a method for increasing the proliferation ability of cells in an epithelial tissue; (iii) a method for producing a cell mass employing these methods; (iv) a pharmaceutical composition containing the cell mass; and, (v) a method for treating a disease using the cell mass. The purpose is fulfilled by culturing a cell mass separated from an epithelial tissue or an epithelial tissue with a thermoreversible polymer.

公开(公告)号：US20230365934A1

公开(公告)日：2023-11-16

申请号：US18027892

申请日：2021-09-22

申请人： JBM Incorporation ,  Mebiol Inc. ,  GN Incorporation Co Ltd

发明人： Shojiro KATOH ,  Hiroshi YOSHIOKA ,  Samuel JK ABRAHAM

IPC分类号： C12N5/077

CPC分类号： C12N5/0655 ,  C12N2533/30

摘要： A first method is provided for increasing the tissue regeneration capacity of a cell population, a cell population production method that includes the first method, and a cell population produced using the production method. The methods for increasing the tissue regeneration capacity of a cell population can include, for example, a step for incubating a cell population in a gel-like thermoreversible polymer solution.

公开(公告)号：US20240285672A1

公开(公告)日：2024-08-29

申请号：US18569553

申请日：2022-06-22

申请人： GN Corporation Co Ltd ,  Sophy Inc.

发明人： TAKASHI ONAKA ,  Samuel JK ABRAHAM

IPC分类号： A61K31/716 ,  A61K36/062 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12

CPC分类号： A61K31/716 ,  A61K36/062 ,  A61P1/16 ,  A61P11/00 ,  A61P13/12

摘要： Compositions and methods for preventing and/or treating fibrosis with a beta-blucan are provided.

公开(公告)号：US20230233596A1

公开(公告)日：2023-07-27

申请号：US18001994

申请日：2021-06-15

申请人： GN Corporation Co Ltd ,  Sophy Inc.

发明人： Takashi ONAKA ,  Samuel JK ABRAHAM

IPC分类号： A61K31/716 ,  A61P35/00 ,  A61P31/14 ,  A61K9/00

CPC分类号： A61K31/716 ,  A61P35/00 ,  A61P31/14 ,  A61K9/0053

摘要： Methods for inducing, enhancing and/or balancing an immune response are provided. The methods include administering a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327). The methods include administering a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327) as a vaccine adjuvant.

公开(公告)号：US20240226136A1

公开(公告)日：2024-07-11

申请号：US18572416

申请日：2022-11-07

申请人： GN Corporation Co Ltd ,  Sophy Inc.

发明人： TAKASHI ONAKA ,  Samuel JK ABRAHAM

IPC分类号： A61K31/716 ,  A61K36/062 ,  A61P21/00

CPC分类号： A61K31/716 ,  A61K36/062 ,  A61P21/00

摘要： A beta-glucan, a composition comprising the beta-glucan, and a method of using the beta-glucan for improving, preventing and/or treating muscular dystrophy are provided.