Method for making cytokine specific antibodies and uses thereof
    3.
    发明授权
    Method for making cytokine specific antibodies and uses thereof 有权
    制备细胞因子特异性抗体的方法及其用途

    公开(公告)号:US07094396B2

    公开(公告)日:2006-08-22

    申请号:US10638234

    申请日:2003-08-08

    IPC分类号: A61K38/20

    摘要: The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.g., eosinophilia and allograft rejection, associated with the production of cytokines, in particular interleukins, e.g., IL-4, IL-5, IL-9, and IL-13, by immunization with the cytokine conjugates or by administration of antibodies specific for the cytokine. This invention also relates to compositions comprising the cytokine conjugates and the conjugates per se.

    摘要翻译: 本发明的方法涉及用细胞因子和载体的缀合物免疫动物以诱导对细胞因子特异性的延长的高滴度抗体应答。 本发明还涉及通过免疫来治疗与细胞因子特别是白细胞介素例如IL-4,IL-5,IL-9和IL-13的产生有关的嗜酸粒细胞增多和同种异体移植排斥的病理状况 与细胞因子缀合物或通过施用对细胞因子特异的抗体。 本发明还涉及包含细胞因子共轭物和缀合物本身的组合物。

    Method of treatment with IL-9 conjugate
    4.
    发明授权
    Method of treatment with IL-9 conjugate 失效
    用IL-9缀合物治疗的方法

    公开(公告)号:US06645486B1

    公开(公告)日:2003-11-11

    申请号:US09490586

    申请日:2000-01-25

    IPC分类号: A61K3820

    摘要: The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.g., eosinophilia and allograft rejection, associated with the production of cytokines, in particular interleukins, e.g., IL-4, IL-5, IL-9, and IL-13, by immunization with the cytokine conjugates or by administration of antibodies specific for the cytokine. This invention also relates to compositions comprising the cytokine conjugates and the conjugates per se.

    摘要翻译: 本发明的方法涉及用细胞因子和载体的缀合物免疫动物以诱导对细胞因子特异性的延长的高滴度抗体应答。 本发明还涉及通过免疫来治疗与细胞因子特别是白细胞介素例如IL-4,IL-5,IL-9和IL-13的产生有关的嗜酸粒细胞增多和同种异体移植排斥的病理状况 与细胞因子缀合物或通过施用对细胞因子特异的抗体。 本发明还涉及包含细胞因子共轭物和缀合物本身的组合物。

    Isolated nucleic acid molecules encoding T cell derived inducible factors
    10.
    发明授权
    Isolated nucleic acid molecules encoding T cell derived inducible factors 失效
    分离编码T细胞衍生的诱导因子的核酸分子

    公开(公告)号:US07081528B2

    公开(公告)日:2006-07-25

    申请号:US09751797

    申请日:2000-12-29

    IPC分类号: C07H21/04

    CPC分类号: C07K14/52

    摘要: The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.

    摘要翻译: 本发明涉及分离核酸分子,其表达被白介素-9上调。 对应于核酸分子的蛋白质的氨基酸序列显示细胞因子的一些结构特征。 除了核酸分子和蛋白质之外,还公开了分子的各种用途。 这些分子被称为T细胞诱导因子。