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公开(公告)号:US09745670B2
公开(公告)日:2017-08-29
申请号:US14449779
申请日:2014-08-01
申请人: Quynh Pham , Upma Sharma , Xuri Yan , John Marini
发明人: Quynh Pham , Upma Sharma , Xuri Yan , John Marini
CPC分类号: D01D5/0069 , D01D5/0061 , D01D5/34
摘要: The present invention relates generally to the field of electrospinning. In particular, the present invention relates to an electrospinning device that includes a slit-fixture defined by an elongate aperture disposed between opposing elements of an electrically conductive material. These elements include a variety of patterns/shapes that affect the flow of fluid through the aperture and the electrical field across the aperture.
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公开(公告)号:US09522215B2
公开(公告)日:2016-12-20
申请号:US14455117
申请日:2014-08-08
申请人: Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
发明人: Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
CPC分类号: A61L24/046 , A61L24/0036 , A61L2400/04 , C08L75/04
摘要: Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
摘要翻译: 提供了用于治疗腔内出血的系统,方法和试剂盒。 该方法利用对封闭空腔施加快速的压力尖峰,然后采用稳态压力或压力。
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公开(公告)号:US2493678A
公开(公告)日:1950-01-03
申请号:US52709744
申请日:1944-03-18
申请人: JOHN MARINI
发明人: JOHN MARINI
IPC分类号: F22B3/04
CPC分类号: F22B3/04
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4.
公开(公告)号:US20160305043A1
公开(公告)日:2016-10-20
申请号:US14637305
申请日:2015-03-03
申请人: Quynh PHAM , Upma Sharma , John Marini , Xuri Yan , Lee Core
发明人: Quynh PHAM , Upma Sharma , John Marini , Xuri Yan , Lee Core
IPC分类号: D01D5/00
CPC分类号: D01D5/003 , D01D5/0069 , D01D5/34
摘要: Devices and methods for high-throughput manufacture of concentrically layered nanoscale and microscale fibers by electrospinning are disclosed. The devices include a hollow tube having a lengthwise slit through which a core material can flow, and can be configured to permit introduction of sheath material at multiple sites of Taylor cone formation formation.
摘要翻译: 公开了通过静电纺丝高分辨率生产同心层状纳米尺度和微细纤维的装置和方法。 这些装置包括具有纵向狭缝的中空管,核心材料可以通过该纵向狭缝流动,并且可以被配置为允许在Taylor锥形成形成的多个位置处引入护套材料。
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5.
公开(公告)号:US08968626B2
公开(公告)日:2015-03-03
申请号:US13362467
申请日:2012-01-31
申请人: Quynh Pham , Upma Sharma , John Marini , Xuri Yan , Lee Core
发明人: Quynh Pham , Upma Sharma , John Marini , Xuri Yan , Lee Core
CPC分类号: D01D5/003 , D01D5/0069 , D01D5/34
摘要: Devices and methods for high-throughput manufacture of concentrically layered nanoscale and microscale fibers by electrospinning are disclosed. The devices include a hollow tube having a lengthwise slit through which a core material can flow, and can be configured to permit introduction of sheath material at multiple sites of Taylor cone formation.
摘要翻译: 公开了通过静电纺丝高分辨率生产同心层状纳米尺度和微细纤维的装置和方法。 这些装置包括具有纵向狭缝的中空管,核心材料可通过该纵向狭缝流动,并且可以构造成允许在泰勒锥形成的多个位置引入护套材料。
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公开(公告)号:US20120299223A1
公开(公告)日:2012-11-29
申请号:US13571545
申请日:2012-08-10
申请人: Maria Palasis , Upma Sharma , Quynh Pham , John Marini
发明人: Maria Palasis , Upma Sharma , Quynh Pham , John Marini
IPC分类号: D01D5/34
CPC分类号: A61K9/7007 , A61K9/0024 , A61K9/0051 , A61K9/0085 , A61K9/0092 , A61K9/70 , A61K31/445 , A61K31/4468 , A61K31/4535 , A61K31/485 , A61K31/573 , A61K31/575 , A61K38/00 , A61K47/34
摘要: Implants and methods for the delivery of a therapeutic agent to a target location within a patient's body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches.
摘要翻译: 公开了用于将治疗剂递送到患者体内的目标位置的植入物和方法。 植入物包括纤维,其包含聚合物材料并且具有直至约20微米的直径,以及纤维内的第一治疗剂。 治疗剂基本上是颗粒形式。 植入物具有各种构造,例如单独的纤维,纱线,绳索,管和贴片。
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公开(公告)号:US20120193836A1
公开(公告)日:2012-08-02
申请号:US13362467
申请日:2012-01-31
申请人: Upma Sharma , Quynh Pham , John Marini , Xuri Yan , Lee Core
发明人: Upma Sharma , Quynh Pham , John Marini , Xuri Yan , Lee Core
CPC分类号: D01D5/003 , D01D5/0069 , D01D5/34
摘要: Devices and methods for high-throughput manufacture of concentrically layered nanoscale and microscale fibers by electrospinning are disclosed. The devices include a hollow tube having a lengthwise slit through which a core material can flow, and can be configured to permit introduction of sheath material at multiple sites of Taylor cone formation.
摘要翻译: 公开了通过静电纺丝高分辨率生产同心层状纳米尺度和微细纤维的装置和方法。 这些装置包括具有纵向狭缝的中空管,核心材料可通过该纵向狭缝流动,并且可以构造成允许在泰勒锥形成的多个位置引入护套材料。
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公开(公告)号:US20160256170A1
公开(公告)日:2016-09-08
申请号:US14212930
申请日:2014-03-14
申请人: Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu
发明人: Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu
CPC分类号: A61B17/12118 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/1205 , A61B2217/005 , A61F2/07 , A61F2/95 , A61F2002/077 , A61M25/0067 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M25/1006 , A61M2025/0004 , A61M2025/0078 , A61M2025/0175
摘要: Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.
摘要翻译: 提供了用于治疗动脉瘤的系统和方法,其利用原位形成聚合物泡沫的制剂。 制剂通常具有大于或小于血液的浮力,并且浮动到动脉瘤的顶部并且从顶部向下或从底部向下沉入泡沫,并且从下向上浮起泡沫。
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公开(公告)号:US20130317418A1
公开(公告)日:2013-11-28
申请号:US13815910
申请日:2013-03-15
申请人: Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人: Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号: A61M37/00
CPC分类号: A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要: Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译: 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统,方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体,以及由一部分,两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时,将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号:US20130313758A1
公开(公告)日:2013-11-28
申请号:US13758208
申请日:2013-02-04
申请人: Upma Sharma , Quynh Pham , John Marini
发明人: Upma Sharma , Quynh Pham , John Marini
CPC分类号: D01D5/0069 , D01D5/0038 , D01D5/0076 , D01D5/34
摘要: Devices and methods for high-throughput manufacture of concentrically layered nanoscale and microscale fibers by electrospinning are disclosed. The devices include a hollow tube having a lengthwise slit through which a core material can flow, and can be configured to permit introduction of sheath material at multiple sites of Taylor cone formation formation.
摘要翻译: 公开了通过静电纺丝高分辨率生产同心层状纳米尺度和微细纤维的装置和方法。 这些装置包括具有纵向狭缝的中空管,核心材料可以通过该纵向狭缝流动,并且可以被配置为允许在Taylor锥形成形成的多个位置处引入护套材料。
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