公开(公告)号：US20240101706A1

公开(公告)日：2024-03-28

申请号：US18478239

申请日：2023-09-29

申请人： The Johns Hopkins University ,  Institute of Biotechnology CAS, V.V.I.

发明人： Cyril Barinka ,  Martin G. Pomper ,  Zora Novakova ,  Catherine A. Foss

IPC分类号： C07K16/30 ,  A61K47/68 ,  A61K49/00 ,  A61K51/10 ,  G01N33/574

CPC分类号： C07K16/3069 ,  A61K47/68 ,  A61K49/0032 ,  A61K49/0058 ,  A61K51/1072 ,  G01N33/57434 ,  A61K39/39558 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/92

摘要： The presently disclosed subject matter provides compositions and methods comprising isolated antibodies that can recognize human prostate-specific membrane antigen (PSMA). The presently disclosed antibodies can be used to for imaging and therapy of PSMA-expressing cancers, such as prostate cancer, in a subject.

公开(公告)号：US20240101426A1

公开(公告)日：2024-03-28

申请号：US18274840

申请日：2022-02-01

申请人： The Johns Hopkins University

发明人： Jonah D. Erlebacher ,  Gina Greenidge

IPC分类号： C01B32/05 ,  B22D11/00 ,  B22D11/06 ,  C21D8/02

CPC分类号： C01B32/05 ,  B22D11/001 ,  B22D11/0611 ,  C21D8/0257 ,  C21D2211/004

摘要： Provided herein are methods of transforming a first carbon material into a second carbon material, and uses thereof.

公开(公告)号：US11938201B2

公开(公告)日：2024-03-26

申请号：US18354282

申请日：2023-07-18

申请人： The Johns Hopkins University

发明人： Xing Yang ,  Sridhar Nimmagadda ,  Steven Rowe ,  Stephanie Slania ,  Martin G. Pomper

IPC分类号： A61K51/00 ,  A61K47/54 ,  A61K51/04 ,  A61M36/14

CPC分类号： A61K51/0485 ,  A61K47/545 ,  A61K51/0478 ,  A61K51/0482

摘要： Imaging and radiotherapeutics agents targeting fibroblast-activation protein-α (FAP-α) and their use in imaging and treating FAP-α related diseases and disorders are disclosed.

公开(公告)号：US20240094207A1

公开(公告)日：2024-03-21

申请号：US18448425

申请日：2023-08-11

申请人： THE JOHNS HOPKINS UNIVERSITY ,  CDI LABORATORIES, INC.

发明人： Ignacio Pino ,  Heng Zhu ,  Jiang Qian ,  Yi Huang

IPC分类号： G01N33/574 ,  G01N33/564 ,  G16H50/20

CPC分类号： G01N33/57423 ,  G01N33/564 ,  G16H50/20

摘要： Biomarkers to screen for, identify, and/or characterize lung cancer in a subject are disclosed. Also disclosed herein are methods for distinguishing lung cancer from another disease. Also disclosed herein are methods for detecting metastasis of a lung cancer in a subject. Also disclosed herein are substrates, arrays, and reagents for use in the methods, and methods of their preparation.

公开(公告)号：US11932970B2

公开(公告)日：2024-03-19

申请号：US16553232

申请日：2019-08-28

申请人： The Johns Hopkins University

发明人： Christopher M. Hoffman, Jr. ,  Matthew P. Yeager ,  Morgana M. Trexler ,  Zhiyong Xia ,  Douglas A. Smith ,  Marcia W. Patchan

IPC分类号： D01F6/60 ,  D04H1/728

CPC分类号： D01F6/605 ,  D04H1/728 ,  D10B2331/021

摘要： A nanofiber comprising a polyamide including at least one substituted phenyl group is provided. The nanofiber includes an average diameter from about 50 to about 1000 nm. A fibrous mat including a plurality of the nanofibers is also provided. A composite including a plurality of the nanofibers and a continuous matrix resin is also provided. A method of forming the nanofibers is also provided.

公开(公告)号：US11932664B2

公开(公告)日：2024-03-19

申请号：US17739669

申请日：2022-05-09

申请人： THE JOHNS HOPKINS UNIVERSITY ,  INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY AS CR v.v.i.

发明人： Barbara Slusher ,  Rana Rais ,  Marcela Krecmerova ,  Tomas Tichy ,  Pavel Majer ,  Andrej Jancarik

IPC分类号： C07F9/6558 ,  C07F9/38 ,  C07F9/40 ,  C07F9/44

CPC分类号： C07F9/65586 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/4075 ,  C07F9/4084 ,  C07F9/4087 ,  C07F9/4465

摘要： Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

公开(公告)号：US20240084324A1

公开(公告)日：2024-03-14

申请号：US18261944

申请日：2022-02-16

申请人： The Johns Hopkins University

发明人： Hai-Quan Mao ,  Yizong Hu ,  Yining Zhu

IPC分类号： C12N15/86 ,  B01F25/25 ,  C12N7/00

CPC分类号： C12N15/86 ,  B01F25/25 ,  C12N7/00 ,  B01F2215/0431 ,  B01F2215/045 ,  C12N2740/15022 ,  C12N2740/15043 ,  C12N2740/15052

摘要： Disclosed are the optimal composition and size of DNA/polycation particles for efficient transfection of viral production cells in both adherent and suspension cultures. The size-dependent feature of DNA/polycation particle-mediated transfection for particles between 50 nm and 1000 nm also is disclosed. A new scalable method based on kinetic control of DNA/polycation nanoparticle assembly to prepare shelf-stable particles with defined sizes between 50 nm and 1000 nm also is disclosed. The presently disclosed DNA/polycation particles yield superior and reproducible transfection activity and shelf stability and can be used as an off-the-shelf product.

公开(公告)号：US20240082108A1

公开(公告)日：2024-03-14

申请号：US18263644

申请日：2022-01-31

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Andrea Gielen ,  Soraya J. Bailey ,  Eileen M. McDonald ,  Nathan W. Scott ,  Christopher Dykes

IPC分类号： A61J1/14 ,  A61J1/03 ,  A61J7/00 ,  A61J7/04

CPC分类号： A61J1/1437 ,  A61J1/03 ,  A61J7/0076 ,  A61J7/0481 ,  A61J2200/70

摘要： Prescription medications, especially opioids, are often abused. The present invention provides a pill dispensing device that is designed to reduce misuse, diversion, and pilfering or prescribed opioids or other medications that may require regulated dispensing. The device of the present invention securely holds a repository of pills and dispenses a single pill only after the allotted prescribed time interval and only after verification of the correct user through the biometric ID device. The dispensing device includes a locked tamper-resistant outer housing, a biometric ID device, a display for alerting the user to critical information, (such as time to the next pill and number of pills remaining) and a secure mechanical pill dispensing mechanism.

公开(公告)号：US11926580B2

公开(公告)日：2024-03-12

申请号：US17268616

申请日：2019-08-30

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： John Pasquale Toscano ,  Vinayak S. Khodade

IPC分类号： C07C335/30

CPC分类号： C07C335/30

摘要： A hydropersulfide precursor compound having the formula (I): formula (I) as defined in the specification. A process for preparing the hydropersulfide precursor, and a method of using the precursor to generate hydropersulfide are also described.

公开(公告)号：US20240076066A1

公开(公告)日：2024-03-07

申请号：US18218646

申请日：2023-07-06

申请人： The Johns Hopkins University

发明人： Joseph L. Moore ,  Max R. Basescu ,  Adam C. Polevoy ,  Bryanna Y. Yeh ,  Luca Scheuer ,  Kevin C. Wolfe

IPC分类号： B64U10/25 ,  B64C19/02 ,  B64U50/13 ,  G05D1/08

CPC分类号： B64U10/25 ,  B64C19/02 ,  B64U50/13 ,  G05D1/0808 ,  B64U2101/30

摘要： A fixed-wing unmanned aerial vehicle (UAV) includes a propeller gimbal operably coupled to the body of the UAV at the forward end and the propeller gimbal is configured to pivot the propeller about a gimbal pivot axis to change a propeller angle. A controller of the UAV may be configured to control an attitude of flight of the UAV by controlling operation of the motor, the propeller gimbal, and the control surface assembly. The controller may be further configured to determine in-flight trajectory modifications that may require high maneuverability via high angle-of-attack attitudes of flight that are implemented via the propeller gimbal and trajectories determined from a dynamics model of the fixed-wing UAV.