公开(公告)号：US20200224335A1

公开(公告)日：2020-07-16

申请号：US16553232

申请日：2019-08-28

Applicant: The Johns Hopkins University

Inventor： Christopher M. Hoffman, JR. ,  Matthew P. Yeager ,  Morgana M. Trexler ,  Zhiyong Xia ,  Douglas A. Smith ,  Marcia W. Patchan

IPC: D01F6/60 ,  D04H1/728

Abstract: A nanofiber comprising a polyamide including at least one substituted phenyl group is provided. The nanofiber includes an average diameter from about 50 to about 1000 nm. A fibrous mat including a plurality of the nanofibers is also provided. A composite including a plurality of the nanofibers and a continuous matrix resin is also provided. A method of forming the nanofibers is also provided.

公开(公告)号：US20150335788A1

公开(公告)日：2015-11-26

申请号：US14639162

申请日：2015-03-05

Applicant: The Johns Hopkins University

Inventor： Zhiyong Xia ,  Chao-Wei Hwang ,  Xiomara Calderon-Colon ,  Virginia E. Bogdan ,  Peter V. Johnston

IPC: A61L27/38 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56

CPC classification number: A61L27/3834 ,  A61K9/0024 ,  A61K9/7007 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/412 ,  A61L2400/12 ,  A61L2430/34

Abstract: A therapeutic patch includes at least one layer of a nanofiber fabric and at least one of a plurality of stem cells or a plurality of stem cell-derived paracrine factors embedded in the nanofiber fabric. The therapeutic patch is produced such that the nanofiber fabric is formed of a nanofiber web.

Abstract translation: 治疗性补片包括至少一层纳米纤维织物和多个干细胞中的至少一种或嵌入在纳米纤维织物中的多种干细胞来源的旁分泌因子。 制备治疗贴片，使得纳米纤维织物由纳米纤维网形成。

公开(公告)号：US11918977B2

公开(公告)日：2024-03-05

申请号：US17892186

申请日：2022-08-22

Applicant: The Johns Hopkins University

Inventor： Christopher M. Hoffman, Jr. ,  Zhiyong Xia ,  James K. Johnson

IPC: B01J20/22 ,  B01D39/08 ,  B01J20/28 ,  B01J20/32 ,  B01J39/08 ,  C02F1/28 ,  C02F101/20 ,  C02F101/36

CPC classification number: B01J20/22 ,  B01D39/086 ,  B01J20/28038 ,  B01J20/3208 ,  B01J20/3221 ,  B01J20/3246 ,  C02F1/288 ,  B01D2239/0478 ,  B01D2239/0618 ,  C02F1/285 ,  C02F2101/20 ,  C02F2101/36

Abstract: Contaminate-sequestering coatings including a network of hydrolyzed silane compounds including a plurality of thiol functional groups, a plurality of fluorinated functionalities, or both are provided. The contaminate-sequestering coatings may sequester one or more per- and polyfluoroalkyl substances (PFAS), heavy metals, biological species or any combination thereof. Methods of functionalizing a substrate surface with contaminate-sequestering functionalities that sequester one or more PFAS, heavy metals, or both are also provided. Methods of removing contaminants from contaminate-containing liquids, and devices including the contaminate-sequestering coatings are also provided.

公开(公告)号：US20190352517A1

公开(公告)日：2019-11-21

申请号：US16241132

申请日：2019-01-07

Applicant: The Johns Hopkins University

Inventor： Zhiyong Xia ,  Adam J. Maisano ,  Lance M. Baird ,  Adam W. Freeman ,  Sara E. Kubik

IPC: C09D7/61 ,  C09D7/40 ,  C09D133/00 ,  C08K3/04 ,  C08K3/34 ,  B05D3/12 ,  B05D3/06

Abstract: A surface treatment formulation configured to inhibit scaling or climbing of a surface is provided. The surface treatment formulation may include a base binding material configured to adhere to the surface and a filler material embedded in the base binding material. The filler material may include a dry lubricant having a layered lamellar structure or low inter filler interaction. Furthermore, the surface treatment formulation may be configured to be activated in order to expose the filler material thereby causing formation of a slippery surface to inhibit the scaling or climbing of the surface.

公开(公告)号：US20170342599A1

公开(公告)日：2017-11-30

申请号：US15468411

申请日：2017-03-24

Applicant: The Johns Hopkins University

Inventor： Matthew P. Yeager ,  Christopher M. Hoffman, JR. ,  Morgana M. Trexler ,  Zhiyong Xia

IPC: D01F6/60 ,  B29C47/00 ,  D01D5/00 ,  C08G69/48 ,  B29K77/00

CPC classification number: D01F6/605 ,  B29C48/022 ,  B29C48/05 ,  B29C48/142 ,  B29K2077/10 ,  C08G69/32 ,  C08G69/48 ,  D01D1/02 ,  D01D5/0038

Abstract: Example methods and articles of manufacture related to electrospun aramid nanofibers are provided. One example method may include forming a resultant solution by reacting a solution of aramids dissolved in a solvent with an electrophile. In this regard, the electrophile may perform a side chain substitution on the dissolved aramids. The example method may further include electrospinning the resultant solution to form an aramid nanofiber.

公开(公告)号：US20170203244A1

公开(公告)日：2017-07-20

申请号：US15285534

申请日：2016-10-05

Applicant: The Johns Hopkins University

Inventor： Zhiyong Xia ,  Brad M. Ward

IPC: B01D39/16 ,  C02F1/00 ,  B01D39/20

CPC classification number: B01D39/1623 ,  B01D39/2041 ,  B01D2239/025 ,  B01D2239/0258 ,  B01D2239/0442 ,  C02F1/001 ,  C02F2101/20 ,  C02F2101/36 ,  C02F2201/008 ,  C02F2303/04 ,  C02F2303/20 ,  C02F2305/08

Abstract: A water purification device includes a heavy metal removal layer configured to remove heavy metal ions and perfluorinated compounds from contaminated water. The water purification device may further include a biological species removal layer configured to remove biological species from the contaminated water and a support layer configured to provide support for the water purification device.

公开(公告)号：US12276631B2

公开(公告)日：2025-04-15

申请号：US17671809

申请日：2022-02-15

Applicant: The Johns Hopkins University

Inventor： Nicholas R. Kantack ,  Jennifer S. Benzing ,  Tessa B. VanVolkenburg ,  Zhiyong Xia ,  Spencer A. Langevin ,  Daniel S. Ayoub

IPC: G01N27/22 ,  G01N33/18 ,  G06F1/10 ,  H03K5/24

Abstract: A sensor for measuring ocean water salinity is described. The sensor may include a measurement clock circuit, a control clock circuit, and a comparator circuit. The measurement clock circuit, having an output that varies with salinity of a fluid, may have a first circuit architecture that includes a capacitive gap assembly that permits a fluid to flow into a gap between two electrodes of the capacitive gap assembly. The control clock circuit, having an output that does not vary with salinity of the fluid, may have a second circuit architecture comprising a capacitor. The comparator circuit may be configured to compare the controlled clock output to the measured clock output over a duration of time to determine a salinity measurement of the fluid. The first circuit architecture may differ from the second circuit architecture in that an electrically connected position of the capacitive gap assembly within the first circuit architecture is the electrically connected position of the capacitor within the second circuit architecture.

公开(公告)号：US20230001381A1

公开(公告)日：2023-01-05

申请号：US17899879

申请日：2022-08-31

Applicant: The Johns Hopkins University

Inventor： Zhiyong Xia ,  Matthew W. Logan ,  Spencer A. Langevin

IPC: B01J20/22 ,  B01D53/26 ,  B01D53/04 ,  B01D53/047 ,  B01D53/28 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  E03B3/28

Abstract: Sorbent materials comprising a nanofiber composite including a polymeric material defining a continuous phase and at least one metal organic framework (MOF) material defining a discontinuous phase are provided. The at least one MOF material is dispersed throughout the continuous phase of the polymeric material. Fibrous mats comprising the sorbent materials are also provided. Water harvesting devices utilizing the sorbent materials are also provided.

公开(公告)号：US10987501B2

公开(公告)日：2021-04-27

申请号：US16728079

申请日：2019-12-27

Applicant: The Johns Hopkins University

Inventor： Chao-Wei Hwang ,  Zhiyong Xia ,  Virginia E. Bogdan ,  Jeffrey A. Brinker ,  Gary Gerstenblith ,  Peter V. Johnston ,  Steven P. Schulman ,  Gordon Tomaselli ,  Robert G. Weiss

IPC: A61M37/00 ,  A61M25/10 ,  A61L33/00 ,  A61L27/18 ,  A61L27/38 ,  A61L27/54 ,  A61L27/56 ,  A61L31/00 ,  A61L31/14 ,  A61L31/16 ,  A61L31/06 ,  A61F2/04 ,  A61L31/10 ,  A61L33/08 ,  A61F2/07

Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.

公开(公告)号：US10913021B2

公开(公告)日：2021-02-09

申请号：US15285534

申请日：2016-10-05

Applicant: The Johns Hopkins University

Inventor： Zhiyong Xia ,  Brad M. Ward

IPC: B01D39/16 ,  B01D39/20 ,  C02F1/00 ,  C02F101/20 ,  C02F101/36

Abstract: A water purification device includes a heavy metal removal layer configured to remove heavy metal ions and perfluorinated compounds from contaminated water. The water purification device may further include a biological species removal layer configured to remove biological species from the contaminated water and a support layer configured to provide support for the water purification device.