公开(公告)号：US20110269762A1

公开(公告)日：2011-11-03

申请号：US12952666

申请日：2010-11-23

Applicant: Peter G. Milner ,  David Jack Ellis

Inventor： Peter G. Milner ,  David Jack Ellis

IPC: A61K31/5377 ,  A61K31/4439 ,  A61P25/00 ,  A61K31/343 ,  A61P9/00 ,  A61K31/437 ,  A61K31/352

CPC classification number: A61K31/437 ,  A61K31/343 ,  A61K31/352 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

Abstract: The subject invention provides methods for reducing stroke rate, methods for preventing atrial remodeling, and methods for reversing atrial remodeling by administering budiodarone to reduce atrial fibrillation (AF) episode duration and an anticoagulant (AC). According to some methods of the invention, the average AF episode duration can be reduced to less than about 24, 5, 3 or 1 hour(s), and the maximum AF episode duration may be reduced to less than about 20, 10 or 5 hours. According to some methods of the invention, the reduced stroke rate upon administration of budiodarone and AC is less than the age-adjusted overall stroke rate. Further, some methods provide that patients who were refractory to one or more anti-arrhythmic drugs prior to administration of budiodarone may also be treated. Some methods provide for prevention of atrial remodeling and others provide for the reversal of atrial remodeling, including methods to quantify the reversal of atrial remodeling. In some methods of the invention, budiodarone is administered 400 mg BID or more preferably 600 mg BID.

Abstract translation: 本发明提供了降低卒中发生率的方法，用于预防心房重塑的方法，以及通过施用贝碘酮以减少心房颤动（AF）发作持续时间和抗凝血剂（AC）来逆转心房重塑的方法。 根据本发明的一些方法，平均AF发作持续时间可以减少到小于约24,5,3或1小时，并且最大AF发作持续时间可以减少到小于约20,10或5 小时。 根据本发明的一些方法，给予布洛诺酮和AC时降低的卒中率小于年龄调整后的总卒中率。 此外，一些方法提供可以治疗在给予他莫达酮之前对一种或多种抗心律失常药物难治的患者。 一些方法可用于预防心房重塑，另一些方法用于预防房颤重建，包括量化逆转心房重塑的方法。 在本发明的一些方法中，给予他达洛酮400mg BID或更优选600mg BID。

公开(公告)号：US06511641B2

公开(公告)日：2003-01-28

申请号：US09892729

申请日：2001-06-27

Applicant: Timothy L. Herman ,  Jack Ellis ,  Floris Y. Tsang ,  Daniel O. Clark ,  Belynda G. Flippo ,  David Inori ,  Keith Kaarup ,  Mark Morgenlaender ,  Aaron Mao

Inventor： Timothy L. Herman ,  Jack Ellis ,  Floris Y. Tsang ,  Daniel O. Clark ,  Belynda G. Flippo ,  David Inori ,  Keith Kaarup ,  Mark Morgenlaender ,  Aaron Mao

IPC: B01D5356

CPC classification number: B01D47/06 ,  B01D53/56 ,  B01D53/74 ,  B01D53/75 ,  F23G7/061 ,  F23J15/022 ,  F23J15/04 ,  F23J2217/105 ,  F23J2219/40

Abstract: An apparatus and method are provided for treating pollutants in a gaseous stream. The apparatus comprises tubular inlets for mixing a gas stream with other oxidative and inert gases for mixture within a reaction chamber. The reaction chamber is heated by heating elements and has orifices through which cool or heated air enters into the central reaction chamber. A process is also provided whereby additional gases are added to the gaseous stream preferably within the temperature range of 650 C-950 C which minimizes or alleviates the production of NOx.

Abstract translation: 提供了一种用于处理气流中的污染物的装置和方法。 该装置包括用于将气流与用于混合物的反应室内的其它氧化和惰性气体混合的管状入口。 反应室由加热元件加热，并具有通过冷却或加热空气进入中央反应室的孔口。 还提供了一种方法，其中优选在650C-950℃的温度范围内将额外的气体加入到气流中，其最小化或减轻NOx的产生。

公开(公告)号：US6078269A

公开(公告)日：2000-06-20

申请号：US967760

申请日：1997-11-10

Applicant: Scott Markwell ,  David L. Hanning ,  Alan Fox ,  Bill Evans ,  Jack Ellis ,  Richard Goldblatt ,  Bob Matson

Inventor： Scott Markwell ,  David L. Hanning ,  Alan Fox ,  Bill Evans ,  Jack Ellis ,  Richard Goldblatt ,  Bob Matson

IPC: G08B17/11 ,  G08B19/00 ,  G08B25/10 ,  H04Q5/22 ,  G08B17/10 ,  G08B23/00

CPC classification number: G08B25/009 ,  G08B17/11 ,  G08B19/005 ,  G08B25/001 ,  G08B25/003 ,  G08B25/10

Abstract: A wireless, battery-operated detection system of a plurality of RF-interconnected detectors is operable over a CSMA-type network and intended to detect the occurrence of a local phenomena and transmit at least one signal to at least one other detector to remotely sound an alarm. Each detector includes a sensor for sensing local phenomena, a transmitter for transmitting RF messages indicative of the phenomena, a receiver for receiving the RF messages, an alarm circuit for sounding an audible alarm indicative of the phenomena and a controller operable to control the mode of operation of each detector, wherein each controller is operable to control all the detectors in the system in response to a stimulus and to control multiple and conflicting signals transmitted among the detectors. The controller includes a prioritization circuit for determining the relative priority of the received RF signals and stimuli indicative of a particular condition to enable the appropriate mode of operation. The controller also includes a timer circuit responsive to the operating mode for enabling the transmitter to transmit RF messages immediately after the receiver is sensed and no longer detects incoming message activity, and where the receiver is sensed at randomized time intervals to reduce the probability of multiple simultaneous transmissions.

Abstract translation: 多个RF互连检测器的无线电池操作的检测系统可在CSMA型网络上操作，并且旨在检测局部现象的发生，并将至少一个信号发送到至少一个其它检测器以远程地发出声音 报警。 每个检测器包括用于感测局部现象的传感器，用于发送表示现象的RF消息的发射机，用于接收RF消息的接收机，用于发出表示现象的可听报警的报警电路，以及控制器， 每个检测器的操作，其中每个控制器可操作以响应于刺激来控制系统中的所有检测器，并且控制在检测器之间传输的多个和冲突的信号。 控制器包括优先化电路，用于确定所接收的RF信号的相对优先级和指示特定条件的刺激以使能适当的操作模式。 该控制器还包括响应于操作模式的定时器电路，使得发送器能够在接收器被感测之后立即发送RF消息，并且不再检测到进入的消息活动，并且其中以随机时间间隔感测接收机以减少多个 同时传输。

公开(公告)号：US20110144199A1

公开(公告)日：2011-06-16

申请号：US12952696

申请日：2010-11-23

Applicant: Peter G. Milner ,  David Jack Ellis

Inventor： Peter G. Milner ,  David Jack Ellis

IPC: A61K31/343 ,  A61P9/00

CPC classification number: A61K31/343

Abstract: The subject invention provides methods for reducing atrial fibrillation (AF) episode duration, methods for reducing stroke rate, methods for increasing time in normal sinus rhythm (NSR), methods for preventing atrial remodeling, and methods for reversing atrial remodeling, all comprising administering an amount of budiodarone effective to reduce AF episode duration.

Abstract translation: 本发明提供减少心房颤动（AF）发作持续时间的方法，降低卒中率的方法，增加正常窦性心律（NSR）时间的方法，预防心房重构的方法，以及逆转心房重构的方法，所有方法均包括给予 有效减少AF发作持续时间的剂量的量。

公开(公告)号：US06261524B1

公开(公告)日：2001-07-17

申请号：US09295182

申请日：1999-04-20

Applicant: Timothy L. Herman ,  Jack Ellis ,  Floris Y. Tsang ,  Daniel O. Clark ,  Belynda Flippo ,  David Inori ,  Keith Kaarup ,  Mark Morgenlaender ,  Aaron Mao

Inventor： Timothy L. Herman ,  Jack Ellis ,  Floris Y. Tsang ,  Daniel O. Clark ,  Belynda Flippo ,  David Inori ,  Keith Kaarup ,  Mark Morgenlaender ,  Aaron Mao

IPC: F01N310

CPC classification number: B01D47/06 ,  B01D53/56 ,  B01D53/74 ,  B01D53/75 ,  F23G7/061 ,  F23J15/022 ,  F23J15/04 ,  F23J2217/105 ,  F23J2219/40

Abstract: An apparatus and method are provided for treating pollutants in a gaseous stream. The apparatus comprises tubular inlets for mixing a gas stream with other oxidative and inert gases for mixture within a reaction chamber. The reaction chamber is heated by heating elements and has orifices through which cool or heated air enters into the central reaction chamber. A process is also provided whereby additional gases are added to the gaseous stream preferably within the temperature range of 650 C.-950° C. which minimizes or alleviates the production of NOx.

Abstract translation: 提供了一种用于处理气流中的污染物的装置和方法。 该装置包括用于将气流与用于混合物的反应室内的其它氧化和惰性气体混合的管状入口。 反应室由加热元件加热，并具有通过冷却或加热空气进入中央反应室的孔口。 还提供了一种方法，其中额外的气体优选在650℃-95℃的温度范围内加入到气流中，这最小化或减轻了NOx的产生。

公开(公告)号：US20110136779A1

公开(公告)日：2011-06-09

申请号：US12952683

申请日：2010-11-23

Applicant: Peter G. Milner ,  David Jack Ellis

Inventor： Peter G. Milner ,  David Jack Ellis

IPC: A61K31/397 ,  A61K31/40 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/444 ,  A61K31/4418 ,  A61K31/37 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/439 ,  A61P9/00 ,  A61P7/02

CPC classification number: A61K31/37 ,  A61K31/397 ,  A61K31/40 ,  A61K31/439 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/5377

Abstract: The subject invention provides methods for reducing stroke rate, methods for preventing atrial remodeling, and methods for reversing atrial remodeling by administering a multiple ion channel blocker anti-arrhythmic to reduce atrial fibrillation (AF) episode duration and an anticoagulant (AC). According to some methods of the invention, the average AF episode duration can be reduced to less than about 24, 5, 3 or 1 hour(s), and the maximum AF episode duration may be reduced to less than about 20, 10 or 5 hours. According to some methods of the invention, the reduced stroke rate upon administration of multiple ion channel blocker and AC is less than the age-adjusted overall stroke rate. Further, some methods provide that patients who were refractory to one or more anti-arrhythmic drugs prior to administration of the multiple ion channel blocker may also be treated. Some methods provide for prevention of atrial remodeling and others provide for the reversal of atrial remodeling, including methods to quantify the reversal of atrial remodeling. In some methods of the invention, budiodarone is administered 400 mg BID or more preferably 600 mg BID.

Abstract translation: 本发明提供了降低卒中发生率的方法，用于预防心房重塑的方法，以及通过施用多重离子通道阻断剂抗心律不齐以减少心房颤动（AF）发作持续时间和抗凝血剂（AC）来逆转心房重构的方法。 根据本发明的一些方法，平均AF发作持续时间可以减少到小于约24,5,3或1小时，并且最大AF发作持续时间可以减少到小于约20,10或5 小时。 根据本发明的一些方法，施用多个离子通道阻滞剂和AC时降低的卒中率小于经年龄调整的总卒中率。 此外，一些方法提供了在给予多重离子通道阻断剂之前对一种或多种抗心律失常药物难治的患者也可以进行治疗。 一些方法可用于预防心房重塑，另一些方法用于预防房颤重建，包括量化逆转心房重塑的方法。 在本发明的一些方法中，给予他达洛酮400mg BID或更优选600mg BID。