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    TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS
    1.
    发明申请
    TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS 审中-公开
    目标纳米颗粒及其用于治疗脑肿瘤的用途

    公开(公告)号：US20140154269A1

    公开(公告)日：2014-06-05

    申请号：US14114051

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  David S. Baskin ,  Martyn A. Sharpe

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  David S. Baskin ,  Martyn A. Sharpe

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0085 ,  A61K9/5123 ,  A61K47/60 ,  A61K47/6925 ,  C12N15/87 ,  C12N2810/859

    摘要： In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.

    摘要翻译： 在一些实施方案中，本发明涉及用于治疗脑肿瘤的治疗组合物。 这样的治疗组合物通常包括：（1）纳维酮; （2）与具有针对脑肿瘤细胞活性的纳米动物相关的活性剂; 和（3）与具有脑肿瘤细胞标志物的识别活性的纳米动物相关的靶向剂。 在一些实施方案中，活性剂和靶向剂与纳米活性剂非共价缔合。 本发明的另外的实施方案涉及通过将上述治疗组合物给予受试者来治疗受试者（例如，人）中的脑肿瘤的方法。 本公开的另外的实施方案涉及以个性化方式配制用于治疗受试者的脑肿瘤的治疗组合物的方法。

    Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins
    3.
    发明申请
    Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins 有权
    有机金属钌络合物及制备四取代的和其他受阻烯烃的相关方法

    公开(公告)号：US20070282148A1

    公开(公告)日：2007-12-06

    申请号：US11640400

    申请日：2006-12-18

    申请人： Jacob Berlin ,  Robert Grubbs ,  Yann Schrodi ,  Ian Stewart

    发明人： Jacob Berlin ,  Robert Grubbs ,  Yann Schrodi ,  Ian Stewart

    IPC分类号： C07F15/00 ,  C07C6/02 ,  C07D213/02 ,  C07D233/02

    CPC分类号： C07F15/0046 ,  B01J31/2265 ,  B01J31/2404 ,  B01J2231/543 ,  B01J2531/821 ,  C08G61/08

    摘要： The invention relates to ruthenium alkylidene complexes having an N-heterocyclic carbene ligand comprising a 5-membered heterocyclic ring having a carbenic carbon atom and at least one nitrogen atom contained within the 5-membered heterocyclic ring, wherein the nitrogen atom is directly attached to the carbenic carbon atom and is substituted by a phenyl ring, and wherein the phenyl ring has a hydrogen at either or both ortho positions and is substituted at at least one ortho or meta position. The invention also relates to an olefin metathesis reactions and particularly to the preparation of tetra-substituted cyclic olefins via a ring-closing metathesis.

    摘要翻译： 本发明涉及具有N-杂环卡宾配位体的钌亚烷基配合物，其包括具有碳原子数为5元的五元杂环和至少一个含有5元杂环的氮原子，其中氮原子直接连接到 碳原子并被苯环取代，并且其中苯环在一个或两个邻位具有氢，并且在至少一个邻位或间位取代。 本发明还涉及烯烃复分解反应，特别涉及通过闭环复分解制备四取代环烯烃。

    Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins
    4.
    发明授权
    Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins 有权
    有机金属钌络合物及制备四取代的和其他受阻烯烃的相关方法

    公开(公告)号：US08361922B2

    公开(公告)日：2013-01-29

    申请号：US13221871

    申请日：2011-08-30

    申请人： Jacob Berlin ,  Robert H. Grubbs ,  Yann Schrodi ,  Ian C. Stewart

    发明人： Jacob Berlin ,  Robert H. Grubbs ,  Yann Schrodi ,  Ian C. Stewart

    IPC分类号： B01J31/00 ,  C07F17/02

    CPC分类号： C07F15/0046 ,  B01J31/2265 ,  B01J31/2404 ,  B01J2231/543 ,  B01J2531/821 ,  C08G61/08

    摘要： The invention relates to ruthenium alkylidene complexes having an N-heterocyclic carbene ligand comprising a 5-membered heterocyclic ring having a carbenic carbon atom and at least one nitrogen atom contained within the 5-membered heterocyclic ring, wherein the nitrogen atom is directly attached to the carbenic carbon atom and is substituted by a phenyl ring, and wherein the phenyl ring has a hydrogen at either or both ortho positions and is substituted at at least one ortho or meta position. The invention also relates to an olefin metathesis reactions and particularly to the preparation of tetra-substituted cyclic olefins via a ring-closing metathesis.

    摘要翻译： 本发明涉及具有N-杂环卡宾配位体的钌亚烷基配合物，其包括具有碳原子数为5元的五元杂环和至少一个含有5元杂环的氮原子，其中氮原子直接连接到 碳原子并被苯环取代，并且其中苯环在一个或两个邻位具有氢，并且在至少一个邻位或间位取代。 本发明还涉及烯烃复分解反应，特别涉及通过闭环复分解制备四取代环烯烃。

    Sensing and Secure Processing
    6.
    发明申请
    Sensing and Secure Processing 审中-公开
    感知和安全处理

    公开(公告)号：US20120185932A1

    公开(公告)日：2012-07-19

    申请号：US13386901

    申请日：2009-07-24

    申请人： Keld Stougaard ,  Jacob Berlin Rasmussen

    发明人： Keld Stougaard ,  Jacob Berlin Rasmussen

    IPC分类号： G06F21/00

    CPC分类号： H04Q9/00 ,  H04Q2209/47 ,  H04W12/10

    摘要： A first and second apparatuses, first and second computer programs and first and second methods are provided. The first apparatus comprises: an interface; and a secure processor configured to control the interface to provide a request, to the second apparatus, requesting information from one or more sensors of the second apparatus. The request may be a data structure comprising an element having one of a multiplicity of predetermined configurations, each configuration identifying at least one of a plurality of sensors. The second apparatus comprises: a further interface; one or more sensors; and a processor configured to receive via the further interface the request, from the secure processor of first apparatus, requesting information from at least one sensor identified in the request. The processor is configured to process the request, to determine whether the second apparatus comprises the at least one sensor identified in the request.

    摘要翻译： 提供了第一和第二装置，第一和第二计算机程序以及第一和第二方法。 第一装置包括：接口; 以及安全处理器，被配置为控制所述接口以向所述第二设备提供从所述第二设备的一个或多个传感器请求信息的请求。 该请求可以是包括具有多个预定配置之一的元件的数据结构，每个配置识别多个传感器中的至少一个。 第二装置包括：另一接口; 一个或多个传感器; 以及处理器，被配置为经由另一接口从第一装置的安全处理器请求从请求中标识的至少一个传感器的信息。 处理器被配置为处理请求，以确定第二装置是否包括在请求中标识的至少一个传感器。

    Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins
    7.
    发明授权
    Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins 有权
    有机金属钌络合物及制备四取代的和其他受阻烯烃的相关方法

    公开(公告)号：US08008224B2

    公开(公告)日：2011-08-30

    申请号：US11640400

    申请日：2006-12-18

    申请人： Jacob Berlin ,  Robert H. Grubbs ,  Yann Schrodi ,  Ian C. Stewart

    发明人： Jacob Berlin ,  Robert H. Grubbs ,  Yann Schrodi ,  Ian C. Stewart

    IPC分类号： B01J31/00 ,  C07F17/02

    CPC分类号： C07F15/0046 ,  B01J31/2265 ,  B01J31/2404 ,  B01J2231/543 ,  B01J2531/821 ,  C08G61/08

    摘要： The invention relates to ruthenium alkylidene complexes having an N-heterocyclic carbene ligand comprising a 5-membered heterocyclic ring having a carbenic carbon atom and at least one nitrogen atom contained within the 5-membered heterocyclic ring, wherein the nitrogen atom is directly attached to the carbenic carbon atom and is substituted by a phenyl ring, and wherein the phenyl ring has a hydrogen at either or both ortho positions and is substituted at at least one ortho or meta position. The invention also relates to an olefin metathesis reactions and particularly to the preparation of tetra-substituted cyclic olefins via a ring-closing metathesis.

    摘要翻译： 本发明涉及具有N-杂环卡宾配位体的钌亚烷基配合物，其包括具有碳原子数为5元的五元杂环和至少一个含有5元杂环的氮原子，其中氮原子直接连接到 碳原子并被苯环取代，并且其中苯环在一个或两个邻位具有氢，并且在至少一个邻位或间位取代。 本发明还涉及烯烃复分解反应，特别涉及通过闭环复分解制备四取代环烯烃。

    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
    9.
    发明授权
    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress 有权
    使用具有抗氧化性能的碳纳米材料来治疗氧化应激

    公开(公告)号：US09572834B2

    公开(公告)日：2017-02-21

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K31/335 ,  A61K9/00 ,  A61K38/00 ,  A61K47/00 ,  A61K33/44 ,  B82Y5/00 ,  A61K45/06 ,  A61K47/48 ,  A61K31/713

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。