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    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress
    2.
    发明授权
    Use of carbon nanomaterials with antioxidant properties to treat oxidative stress 有权
    使用具有抗氧化性能的碳纳米材料来治疗氧化应激

    公开(公告)号：US09572834B2

    公开(公告)日：2017-02-21

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K31/335 ,  A61K9/00 ,  A61K38/00 ,  A61K47/00 ,  A61K33/44 ,  B82Y5/00 ,  A61K45/06 ,  A61K47/48 ,  A61K31/713

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

    USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS
    3.
    发明申请
    USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS 有权
    使用碳纳米微粒与抗氧化性能来处理氧化应激

    公开(公告)号：US20140120081A1

    公开(公告)日：2014-05-01

    申请号：US14114007

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  Ashley Leonard ,  Thomas A. Kent ,  Robia G. Pautler ,  Brittany Bitner ,  Taeko Inoue

    IPC分类号： A61K33/44 ,  A61K45/06 ,  A61K47/48

    CPC分类号： A61K33/44 ,  A61K9/0019 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/6925 ,  B82Y5/00 ,  A61K2300/00

    摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

    摘要翻译： 在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。 在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。 在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。 在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳 黑色，氧化炭黑，亲水性碳簇及其组合。 在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。 在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。 在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。 本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

    GRAPHENE NANORIBBONS PREPARED FROM CARBON NANOTUBES VIA ALKALIMETAL EXPOSURE
    5.
    发明申请
    GRAPHENE NANORIBBONS PREPARED FROM CARBON NANOTUBES VIA ALKALIMETAL EXPOSURE 有权
    通过碱金属曝光从碳纳米管制备的石墨纳米颗粒

    公开(公告)号：US20120197051A1

    公开(公告)日：2012-08-02

    申请号：US13378528

    申请日：2010-06-11

    申请人： James M. Tour ,  Dmitry Kosynkin

    发明人： James M. Tour ,  Dmitry Kosynkin

    IPC分类号： C07C15/20 ,  C07C1/32 ,  B82Y40/00

    CPC分类号： C01B31/0446 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15 ,  C01B32/184 ,  C01B32/19 ,  C01B2204/06 ,  C07C1/32 ,  C07C15/20 ,  Y10S977/896

    摘要： In various embodiments, the present disclosure describes processes for preparing functionalized graphene nanoribbons from carbon nanotubes. In general, the processes include exposing a plurality of carbon nanotubes to an alkali metal source in the absence of a solvent and thereafter adding an electrophile to form functionalized graphene nanoribbons. Exposing the carbon nanotubes to an alkali metal source in the absence of a solvent, generally while being heated, results in opening of the carbon nanotubes substantially parallel to their longitudinal axis, which may occur in a spiralwise manner in an embodiment. The graphene nanoribbons of the present disclosure are functionalized on at least their edges and are substantially defect free. As a result, the functionalized graphene nanoribbons described herein display a very high electrical conductivity that is comparable to that of mechanically exfoliated graphene.

    摘要翻译： 在各种实施方案中，本公开描述了从碳纳米管制备官能化石墨烯纳米带的方法。 通常，该方法包括在不存在溶剂的情况下将多个碳纳米管暴露于碱金属源，然后加入亲电体以形成官能化的石墨烯纳米带。 通常在加热的情况下，将碳纳米管暴露于碱金属源，通常在被加热的情况下导致碳纳米管的开口基本上平行于它们的纵向轴线，这在实施例中可以以螺旋方式发生。 本公开的石墨烯纳米带至少在其边缘上被官能化，并且基本上是无缺陷的。 因此，本文所述的功能化石墨烯纳米带显示出与机械剥离的石墨烯相当的非常高的电导率。

    Graphene nanoribbons prepared from carbon nanotubes via alkali metal exposure
    6.
    发明授权
    Graphene nanoribbons prepared from carbon nanotubes via alkali metal exposure 有权
    通过碱金属曝光从碳纳米管制备的石墨烯纳米带

    公开(公告)号：US08992881B2

    公开(公告)日：2015-03-31

    申请号：US13378528

    申请日：2010-06-11

    申请人： James M. Tour ,  Dmitry Kosynkin

    发明人： James M. Tour ,  Dmitry Kosynkin

    IPC分类号： C01B31/06 ,  C01B31/04 ,  C07C1/32 ,  C07C15/20 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/02

    CPC分类号： C01B31/0446 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/15 ,  C01B32/184 ,  C01B32/19 ,  C01B2204/06 ,  C07C1/32 ,  C07C15/20 ,  Y10S977/896

    摘要： In various embodiments, the present disclosure describes processes for preparing functionalized graphene nanoribbons from carbon nanotubes. In general, the processes include exposing a plurality of carbon nanotubes to an alkali metal source in the absence of a solvent and thereafter adding an electrophile to form functionalized graphene nanoribbons. Exposing the carbon nanotubes to an alkali metal source in the absence of a solvent, generally while being heated, results in opening of the carbon nanotubes substantially parallel to their longitudinal axis, which may occur in a spiralwise manner in an embodiment. The graphene nanoribbons of the present disclosure are functionalized on at least their edges and are substantially defect free. As a result, the functionalized graphene nanoribbons described herein display a very high electrical conductivity that is comparable to that of mechanically exfoliated graphene.

    摘要翻译： 在各种实施方案中，本公开描述了从碳纳米管制备官能化石墨烯纳米带的方法。 通常，该方法包括在不存在溶剂的情况下将多个碳纳米管暴露于碱金属源，然后加入亲电体以形成官能化的石墨烯纳米带。 通常在加热的情况下，将碳纳米管暴露于碱金属源，通常在被加热的情况下导致碳纳米管的开口基本上平行于它们的纵向轴线，这在实施例中可以以螺旋方式发生。 本公开的石墨烯纳米带至少在其边缘上被官能化，并且基本上是无缺陷的。 因此，本文所述的功能化石墨烯纳米带显示出与机械剥离的石墨烯相当的非常高的电导率。

    TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS
    8.
    发明申请
    TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS 审中-公开
    目标纳米颗粒及其用于治疗脑肿瘤的用途

    公开(公告)号：US20140154269A1

    公开(公告)日：2014-06-05

    申请号：US14114051

    申请日：2012-04-26

    申请人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  David S. Baskin ,  Martyn A. Sharpe

    发明人： James M. Tour ,  Jacob Berlin ,  Daniela Marcano ,  David S. Baskin ,  Martyn A. Sharpe

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0085 ,  A61K9/5123 ,  A61K47/60 ,  A61K47/6925 ,  C12N15/87 ,  C12N2810/859

    摘要： In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner.

    摘要翻译： 在一些实施方案中，本发明涉及用于治疗脑肿瘤的治疗组合物。 这样的治疗组合物通常包括：（1）纳维酮; （2）与具有针对脑肿瘤细胞活性的纳米动物相关的活性剂; 和（3）与具有脑肿瘤细胞标志物的识别活性的纳米动物相关的靶向剂。 在一些实施方案中，活性剂和靶向剂与纳米活性剂非共价缔合。 本发明的另外的实施方案涉及通过将上述治疗组合物给予受试者来治疗受试者（例如，人）中的脑肿瘤的方法。 本公开的另外的实施方案涉及以个性化方式配制用于治疗受试者的脑肿瘤的治疗组合物的方法。