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1.发明授权Method of screening a compound for anxiolytic activity in an Apolipoprotein e knockout animal 有权在载脂蛋白e敲除动物中筛选化合物抗焦虑活性的方法公开(公告)号：US06982361B1
公开(公告)日：2006-01-03
申请号：US09512840
申请日：2000-02-25
申请人： Jacob Raber , Lennart Mucke
发明人： Jacob Raber , Lennart Mucke
IPC分类号： G01N3/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A61K38/1709
摘要： Methods and compositions for use in treating anxiety are provided. In the subject methods, an effective amount of an agent having ApoE3 activity is administered to a host suffering from an anxiety, e.g. excessive anxiety, unwanted anxiety, an anxiety disorder, etc. Also provided are methods and compositions for modulating adrenal steroidogenesis and/or release, particularly stress induced adrenal steroidogenesis and/or release, and the hippocampal-pituitary-adrenal (HPA) axis. In these methods, an effective amount of an ApoE activity modulating agent, e.g. an ApoE agonist or antagonist, is administered to the host.
摘要翻译： 提供了用于治疗焦虑症的方法和组合物。 在本发明的方法中，将有效量的具有ApoE3活性的药剂施用于患有焦虑的宿主，例如， 过度焦虑，不需要的焦虑，焦虑症等。还提供了用于调节肾上腺类固醇生成和/或释放，特别是应激诱发的肾上腺类固醇生成和/或释放以及海马 - 垂体 - 肾上腺（HPA）轴的方法和组合物。 在这些方法中，有效量的ApoE活性调节剂，例如， 给予宿主ApoE激动剂或拮抗剂。
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公开(公告)号：US08475171B2
公开(公告)日：2013-07-02
申请号：US13434297
申请日：2012-03-29
申请人： Jacob Raber
发明人： Jacob Raber
IPC分类号： G09B19/00
CPC分类号： G06F19/34 , A61B3/032 , A61B5/16 , A61B5/4088 , A61B5/7264
摘要： Techniques and tools for measuring cognitive ability and/or detecting cognitive impairment or decline. For example, techniques and tools are described that can be used to diagnose or test susceptibility to cognitive impairments in children or in elderly people (such as cognitive impairments associated with Alzheimer's Disease). Techniques and tools are described that can be used to evaluate treatment effects and/or measure cognitive decline over time.
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3.发明申请OBJECT RECOGNITION TESTING TOOLS AND TECHNIQUES FOR MEASURING COGNITIVE ABILITY AND COGNITIVE IMPAIRMENT 有权对象识别测试工具和测量认知能力和认知功能的技术公开(公告)号：US20120190968A1
公开(公告)日：2012-07-26
申请号：US13434297
申请日：2012-03-29
申请人： Jacob Raber
发明人： Jacob Raber
CPC分类号： G06F19/34 , A61B3/032 , A61B5/16 , A61B5/4088 , A61B5/7264
摘要： Techniques and tools for measuring cognitive ability and/or detecting cognitive impairment or decline. For example, techniques and tools are described that can be used to diagnose or test susceptibility to cognitive impairments in children or in elderly people (such as cognitive impairments associated with Alzheimer's Disease). Techniques and tools are described that can be used to evaluate treatment effects and/or measure cognitive decline over time.
摘要翻译： 用于测量认知能力和/或检测认知障碍或衰退的技术和工具。 例如，描述了可用于诊断或测试儿童或老年人（例如与阿尔茨海默病相关的认知障碍）对认知障碍的易感性的技术和工具。 描述了可用于评估治疗效果和/或测量随时间的认知衰退的技术和工具。
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4.发明申请Object recognition testing tools and techniques for measuring cognitive ability and cognitive impairment 审中-公开用于测量认知能力和认知障碍的对象识别测试工具和技术公开(公告)号：US20090298025A1
公开(公告)日：2009-12-03
申请号：US11888091
申请日：2007-07-30
申请人： Jacob Raber
发明人： Jacob Raber
IPC分类号： G09B19/00
CPC分类号： G06F19/34 , A61B3/032 , A61B5/16 , A61B5/4088 , A61B5/7264
摘要： Techniques and tools for measuring cognitive ability and/or detecting cognitive impairment or decline. For example, techniques and tools are described that can be used to diagnose or test susceptibility to cognitive impairments in children or in elderly people (such as cognitive impairments associated with Alzheimer's Disease). Techniques and tools are described that can be used to evaluate treatment effects and/or measure cognitive decline over time.
摘要翻译： 用于测量认知能力和/或检测认知障碍或衰退的技术和工具。 例如，描述了可用于诊断或测试儿童或老年人（例如与阿尔茨海默病相关的认知障碍）对认知障碍的易感性的技术和工具。 描述了可用于评估治疗效果和/或测量随时间的认知衰退的技术和工具。
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5.发明申请Virtual reality tools and techniques for measuring cognitive ability and cognitive impairment 审中-公开用于测量认知能力和认知障碍的虚拟现实工具和技术公开(公告)号：US20080280276A1
公开(公告)日：2008-11-13
申请号：US11888109
申请日：2007-07-30
申请人： Jacob Raber , Dean Inman
发明人： Jacob Raber , Dean Inman
IPC分类号： A61B5/00
CPC分类号： G06F19/34 , A61B3/032 , A61B5/16 , A61B5/4088 , A61B5/7264
摘要： Techniques and tools for measuring cognitive ability and/or detecting cognitive impairment or decline. For example, techniques and tools are described that can be used to diagnose or test susceptibility to cognitive impairments in children or in elderly people (such as cognitive impairments associated with Alzheimer's Disease). Techniques and tools are described that can be used to evaluate treatment effects and/or measure cognitive decline over time.
摘要翻译： 用于测量认知能力和/或检测认知障碍或衰退的技术和工具。 例如，描述了可用于诊断或测试儿童或老年人（例如与阿尔茨海默病相关的认知障碍）对认知障碍的易感性的技术和工具。 描述了可用于评估治疗效果和/或测量随时间的认知衰退的技术和工具。
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公开(公告)号：US6046381A
公开(公告)日：2000-04-04
申请号：US70670
申请日：1998-04-30
IPC分类号： A01K67/027 , C07K14/775 , C12N5/10 , C12N15/09 , C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： A01K67/0276 , A01K67/0278 , C07K14/775 , C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0318 , A01K2267/0356 , C12N2830/008
摘要： The present invention features non-human transgenic animal models for gene function, wherein the transgenic animal is characterized by having altered endogenous apolipoprotein E gene function and a transgene for an exogenous human apolipoprotein E isoform. The transgenic animals may be either homozygous or heterozygous for the transgene. The invention also features methods for using non-human transgenic animal models for the study of apolipoprotein E-mediated pathologies and the identification of compounds and therapies for such pathologies.
摘要翻译： 本发明的特征在于用于基因功能的非人转基因动物模型，其中所述转基因动物的特征在于具有改变的内源载脂蛋白E基因功能和外源人载脂蛋白E同种型的转基因。 转基因动物对于转基因可以是纯合的或杂合的。 本发明还具有使用非人转基因动物模型研究载脂蛋白E介导的病理学的方法以及鉴定这些病理学的化合物和疗法。
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公开(公告)号：US20200340273A1
公开(公告)日：2020-10-29
申请号：US16397315
申请日：2019-04-29
申请人： Jacob Raber
发明人： Jacob Raber
摘要： A locking mechanism for double doors includes a three-sided bar having a top side and a pair of vertical sides extending downwardly from the edges of the top side. Each vertical side includes a slot formed therein. An L-shaped bracket has a first section for attachment to an interior surface of a door, and a second section that extends through a slot in the door outwardly through the exterior side of the door. To lock the doors, the second portion of the bracket slides through the slots in the vertical sides of the bar. A lock hole is positioned on the second portion of the bracket, and when the three-sided bar is engaged with the bracket and the lock hole is positioned between the vertical sides of the bar, a padlock or combination lock engages the lock hole to hold the bar in place across the double doors.
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8.发明申请Method of screening a compound for anxiolytic activity in an apolipoprotein E knockout animal 审中-公开在载脂蛋白E敲除动物中筛选化合物抗焦虑活性的方法公开(公告)号：US20050245450A1
公开(公告)日：2005-11-03
申请号：US11175779
申请日：2005-07-05
申请人： Jacob Raber , Lennart Mucke
发明人： Jacob Raber , Lennart Mucke
IPC分类号： A01K67/027 , A61K38/17 , A61K48/00 , C12N15/85
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2267/03 , A61K38/1709
摘要： Methods and compositions for use in treating anxiety are provided. In the subject methods, an effective amount of an agent having ApoE3 activity is administered to a host suffering from an anxiety, e.g. excessive anxiety, unwanted anxiety, an anxiety disorder, etc. Also provided are methods and compositions for modulating adrenal steroidogenesis and/or release, particularly stress induced adrenal steroidogenesis and/or release, and the hippocampal-pituitary-adrenal (HPA) axis. In these methods, an effective amount of an ApoE activity modulating agent, e.g. an ApoE agonist or antagonist, is administered to the host.
摘要翻译： 提供了用于治疗焦虑症的方法和组合物。 在本发明的方法中，将有效量的具有ApoE3活性的药剂施用于患有焦虑的宿主，例如， 过度焦虑，不需要的焦虑，焦虑症等。还提供了用于调节肾上腺类固醇生成和/或释放，特别是应激诱发的肾上腺类固醇生成和/或释放以及海马 - 垂体 - 肾上腺（HPA）轴的方法和组合物。 在这些方法中，有效量的ApoE活性调节剂，例如， 给予宿主ApoE激动剂或拮抗剂。
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