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公开(公告)号：US6046381A
公开(公告)日：2000-04-04
申请号：US70670
申请日：1998-04-30
IPC分类号： A01K67/027 , C07K14/775 , C12N5/10 , C12N15/09 , C12N15/85 , C12N5/00 , C12N15/00
CPC分类号： A01K67/0276 , A01K67/0278 , C07K14/775 , C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0318 , A01K2267/0356 , C12N2830/008
摘要： The present invention features non-human transgenic animal models for gene function, wherein the transgenic animal is characterized by having altered endogenous apolipoprotein E gene function and a transgene for an exogenous human apolipoprotein E isoform. The transgenic animals may be either homozygous or heterozygous for the transgene. The invention also features methods for using non-human transgenic animal models for the study of apolipoprotein E-mediated pathologies and the identification of compounds and therapies for such pathologies.
摘要翻译： 本发明的特征在于用于基因功能的非人转基因动物模型，其中所述转基因动物的特征在于具有改变的内源载脂蛋白E基因功能和外源人载脂蛋白E同种型的转基因。 转基因动物对于转基因可以是纯合的或杂合的。 本发明还具有使用非人转基因动物模型研究载脂蛋白E介导的病理学的方法以及鉴定这些病理学的化合物和疗法。
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公开(公告)号：US20060058233A1
公开(公告)日：2006-03-16
申请号：US11185907
申请日：2005-07-19
申请人： Dale Schenk , Eliezer Masliah , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Kate Games
发明人： Dale Schenk , Eliezer Masliah , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Kate Games
IPC分类号： A61K38/17
CPC分类号： C07K16/18 , A61K38/1709 , A61K39/00 , A61K2039/505 , A61P25/16 , A61P25/28
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
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3.发明申请公开(公告)号：US20080014194A1
公开(公告)日：2008-01-17
申请号：US11697646
申请日：2007-04-06
申请人： Dale Schenk , Kcote Games , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Eliezar Masliah
发明人： Dale Schenk , Kcote Games , Manuel Buttini , Tamie Chilcote , Edward Rockenstein , Eliezar Masliah
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/34
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
摘要翻译： 本发明提供用于治疗与突触核蛋白病相关疾病（包括患者脑中的α-突触核蛋白的路易体）的改进剂和方法。 这种方法需要对路易体诱导有益的免疫原性应答的给药剂。 该方法对帕金森病的预防和治疗特别有用。
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公开(公告)号：US08506959B2
公开(公告)日：2013-08-13
申请号：US11185907
申请日：2005-07-19
申请人： Dale B. Schenk , Eliezer Masliah , Manuel Buttini , Tamie J. Chilcote , Edward M. Rockenstein , Kate Dora Games
发明人： Dale B. Schenk , Eliezer Masliah , Manuel Buttini , Tamie J. Chilcote , Edward M. Rockenstein , Kate Dora Games
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K38/1709 , A61K39/00 , A61K2039/505 , A61P25/16 , A61P25/28
摘要： The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful for prophylactic and therapeutic treatment of Parkinson's disease.
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