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    Fibrin material and method for producing and using the same
    1.
    发明授权
    Fibrin material and method for producing and using the same 失效
    纤维蛋白原料及其制造及使用方法

    公开(公告)号：US06965014B1

    公开(公告)日：2005-11-15

    申请号：US09566019

    申请日：2000-05-08

    Applicant: Yves Delmotte ,  James Diorio

    Inventor： Yves Delmotte ,  James Diorio

    IPC: A61K35/14 ,  A61K38/00 ,  A61K38/36 ,  A61K38/48 ,  A61L31/04 ,  A61L31/14 ,  C07K1/00 ,  C07K14/00 ,  C07K14/75 ,  C07K16/00

    CPC classification number: A61K38/363 ,  A61K38/4833 ,  A61L31/046 ,  A61L31/145 ,  A61L31/146 ,  C07K14/75 ,  A61K2300/00

    Abstract: This invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium. Such a fibrin-based biomaterial develops a tight structure with thin fibers and small pore size suitable for use as an anti-adhesion barrier. In this invention, thrombin is no longer the variable which governs the tightness and the porosity of the fibrin material obtained, but still controls the clotting time. The mechanical behavior, high-water capacity, and releasable retention properties for therapeutic agents of this fibrin structure causes the fibrin material to be ideally suited for use as a drug delivery device, capable of delivering proteins, hormones, enzymes, antibiotics, antineoplastic agents and even cells for local and systemic treatment of human and non-human patients.

    Abstract translation: 本发明描述了通过混合纤维蛋白原和凝血酶获得的生物浸渍纤维蛋白材料，所述纤维蛋白原和凝血酶用特定的高强度强力培养基重新配制或稀释，不含钙。 这种基于纤维蛋白的生物材料用适合用作抗粘连屏障的细纤维和小孔径形成紧密结构。 在本发明中，凝血酶不再是控制所获得的纤维蛋白材料的紧密度和孔隙度的变量，而是控制凝血时间。 该纤维蛋白结构的治疗剂的机械性能，高水容量和可释放的保留性质使得纤维蛋白材料理想地适合用作药物递送装置，能够递送蛋白质，激素，酶，抗生素，抗肿瘤剂和 甚至用于局部和全身治疗人和非人类患者的细胞。

    Fibrin delivery device and method for forming fibrin on a surface
    4.
    发明授权
    Fibrin delivery device and method for forming fibrin on a surface 有权
    纤维蛋白递送装置和在表面上形成纤维蛋白的方法

    公开(公告)号：US06461325B1

    公开(公告)日：2002-10-08

    申请号：US09386198

    申请日：1999-08-31

    Applicant: Yves Delmotte ,  Arnold Bilstad ,  David Amrani ,  James DiOrio ,  Atif M. Yardimci ,  David W. Pennington ,  James S. Slepicka ,  Cristina Stadler

    Inventor： Yves Delmotte ,  Arnold Bilstad ,  David Amrani ,  James DiOrio ,  Atif M. Yardimci ,  David W. Pennington ,  James S. Slepicka ,  Cristina Stadler

    IPC: A61M3700

    CPC classification number: A61B17/00491 ,  A61B2017/00495 ,  B05B11/0078 ,  B05B11/02

    Abstract: This invention provides a medical device for delivering volumetric quantities of a first and a second biochemically reactive fluid comprising a first container having an opening, the first container being adapted to contain the first biochemically reactive fluid; a second container having a second fluid opening adjacent the first fluid opening, the second container being adapted to contain the second biochemically reactive fluid; a spray unit for separately atomizing the first and second biochemically reactive fluids into an aerosol with at least one energy source of a liquid energy, a mechanical energy, a vibration energy, and an electric energy; a fluid pressurizer for pressurizing the first and the second biochemically reactive fluids for delivery under pressure through the spray unit onto a surface; and wherein the first and second biochemically reactive fluids first mix on the surface.

    Abstract translation: 本发明提供了一种用于输送体积量的第一和第二生物化学反应性流体的医疗装置，其包括具有开口的第一容器，所述第一容器适于容纳所述第一生化反应性流体; 第二容器，具有与第一流体开口相邻的第二流体开口，第二容器适于容纳第二生化反应流体; 用于将第一和第二生化反应性流体分别雾化成具有液体能量，机械能，振动能量和电能的至少一个能量源的气溶胶的喷雾单元; 流体加压器，用于对第一和第二生化反应流体进行加压，以在压力下通过喷雾单元输送到表面上; 并且其中所述第一和第二生化反应性流体首先在所述表面上混合。

    FIBRIN MATERIAL AND METHOD FOR PRODUCING AND USING THE SAME
    5.
    发明申请
    FIBRIN MATERIAL AND METHOD FOR PRODUCING AND USING THE SAME 审中-公开
    纤维材料及其制造和使用方法

    公开(公告)号：US20060134094A2

    公开(公告)日：2006-06-22

    申请号：US11112156

    申请日：2005-04-22

    Applicant: YVES DELMOTTE ,  James Diorio

    Inventor： YVES DELMOTTE ,  James Diorio

    IPC: A61K38/48

    CPC classification number: A61K38/363 ,  A61K38/4833 ,  A61L31/046 ,  A61L31/145 ,  A61L31/146 ,  C07K14/75 ,  A61K2300/00

    Abstract: Abstract of the DisclosureThis invention describes a bioerodible fibrin material which is obtained by mixing fibrinogen and thrombin reconstituted or diluted with a particular high tonic strength medium, free of calcium. Such a fibrin-based biomaterial develops a tight structure with thin fibers and small pore size suitable for use as an anti-adhesion barrier. In this invention, thrombin is no longer the variable which governs the tightness and the porosity of the fibrin material obtained, but still controls the clotting time. The mechanical behavior, high-water capacity, and releasable retention properties for therapeutic agents of this fibrin structure causes the fibrin material to be ideally suited for use as a drug delivery device, capable of delivering proteins, hormones, enzymes, antibiotics, antineoplastic agents and even cells for local and systemic treatment of human and non-human patients.

    Abstract translation: 本发明摘要本发明描述了一种生物浸渗性纤维蛋白材料，其通过将纤维蛋白原和凝血酶与特定的高强度强力培养基（不含钙）重构或稀释而获得。 这种基于纤维蛋白的生物材料用适合用作抗粘连屏障的细纤维和小孔径形成紧密结构。 在本发明中，凝血酶不再是控制所获得的纤维蛋白材料的紧密度和孔隙度的变量，而是控制凝血时间。 这种纤维蛋白结构的治疗剂的机械性能，高水容量和可释放的保留性质使得纤维蛋白材料理想地适合用作药物递送装置，能够递送蛋白质，激素，酶，抗生素，抗肿瘤剂和 甚至用于局部和全身治疗人和非人类患者的细胞。

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