摘要:
The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
摘要:
The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
An improved pilot valve assembly (14) for hydraulically controlling a pressure reducing valve (12) to maintain and further vary the outlet pressure (P2) of the pressure reducing valve (12) in response to increased flow (f) through the valve (12). The pilot valve assembly (14) comprising first and second movable valve members (100,102). The first and second moveable members (100,102) being acted on by a velocity head pressure sensed by a downstream Pitot tube (90) and a downstream outlet pressure (P2) in a balanced arrangement such that they move in response to both the velocity head and downstream pressure (P2) to open and close the pilot valve (14) and so main valve (12) to both maintain and vary the outlet pressure (P2).
摘要:
A cord material dispenser comprising a container including a surrounding sidewall having first and second openings and first and second cord materials disposed in the container. The first and second cord materials are dispensable through their respective first and second openings. The first cord material is preferably wound around a first spool and the second cord material is preferably wound around a second spool. The dispenser may include a first quantity of the first cord material and a second quantity of the second cord material, wherein the first quantity is less than the second quantity. For example, the first quantity may be one fourth of the second quantity. Preferably, the container includes indicia indicative of the ratio of the first quantity to the second quantity. The indicia may be in the form of a graphic representative of the intended use of the spooled materials.
摘要:
A no flow fluxing underfill having a hardener component comprising a phenolic component and an anhydride component in a molar ratio of phenolic component to anhydride component of between about 0.1:1 and about 2:1; or between about 0.8:1 and about 1.2:1. An underfill preparation method involving blending an epoxy component and a phenolic component, heating the blend, and cooling the blend, prior to incorporation of an anhydride component.
摘要:
Apparatuses are provided that include a rifle stock. For example, in one embodiment the stock includes an upper portion. The upper portion includes a proximal end and a distal end. A front portion and a rear portion are connected to the proximal end and the distal end of the upper portion, respectively. A bottom portion is connected to the front portion and rear portion. A first sidewall and a second sidewall are connected to the upper portion, the front portion, the rear portion, and the bottom portion. A channel is provided between the first and second sidewall. The upper portion, the front portion, the rear portion, and the bottom portion further define the channel. The first and second sidewalls include openings for accessing a computer device residing in the channel.
摘要:
An anchor apparatus, ground anchor system, and method of using a ground anchor system are provided. The anchor apparatus includes a base plate having a top surface and a substantially planar bottom surface, wherein the base plate has a plurality of picket-guide apertures formed therein between the top surface and the substantially planar bottom surface. At least one picket is removably positioned in at least a portion of the picket-guide apertures. An anchor portion is formed at a first end of the base plate, wherein the anchor portion has an anchor aperture formed through the first end of the base plate, the anchor portion further comprising a ground face surface proximate to the anchor aperture, wherein a distance between the top surface and the ground face surface is less than a distance between the top surface and the substantially planar bottom surface.
摘要:
The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要:
A cord material dispenser comprising a container including a surrounding sidewall having first and second openings and first and second cord materials disposed in the container. The first and second cord materials are dispensable through their respective first and second openings. The first cord material is preferably wound around a first spool and the second cord material is preferably wound around a second spool. The dispenser may include a first quantity of the first cord material and a second quantity of the second cord material, wherein the first quantity is less than the second quantity. For example, the first quantity may be one fourth of the second quantity. Preferably, the container includes indicia indicative of the ratio of the first quantity to the second quantity. The indicia may be in the form of a graphic representative of the intended use of the spooled materials.
摘要:
The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.