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公开(公告)号：US5574143A
公开(公告)日：1996-11-12
申请号：US195735
申请日：1994-02-08
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N9/10 , A61K38/45 , C12N15/54 , C12N15/64
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
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公开(公告)号：US5543508A
公开(公告)日：1996-08-06
申请号：US195072
申请日：1994-02-08
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N15/11 , C12N15/70 , C12N15/74 , C12N15/79
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise nucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
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公开(公告)号：US5494814A
公开(公告)日：1996-02-27
申请号：US967693
申请日：1992-10-27
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N5/10 , C12N9/22 , C12N15/54 , C12Q1/68
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
摘要翻译： 描述具有高度特异性内切核糖核酸酶活性的化合物。 本发明的化合物也称为核酶，其包含具有两个具有能够与靶RNA杂交的预定序列的区域的核糖核苷酸，定义的序列区域和碱基配对的茎区域。
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公开(公告)号：US5589580A
公开(公告)日：1996-12-31
申请号：US195747
申请日：1994-02-08
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N15/11 , C12N15/70 , C12N15/74 , C12N15/79
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise nucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
摘要翻译： 描述具有高度特异性内切核糖核酸酶活性的化合物。 本发明的化合物，也称为核酶，包含具有两个具有能够与靶RNA杂交的预定序列的两个杂交区域，定义序列区域和碱基配对干区域的核苷酸。
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公开(公告)号：US5254678A
公开(公告)日：1993-10-19
申请号：US926148
申请日：1992-08-05
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N15/11 , C12N15/70 , C12N15/74 , C12N15/79
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
摘要翻译： 描述具有高度特异性内切核糖核酸酶活性的化合物。 本发明的化合物也称为核酶，其包含具有两个具有能够与靶RNA杂交的预定序列的区域的核糖核苷酸，定义的序列区域和碱基配对的茎区域。
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