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    Method and mould for casting articles with a pre-determined crytalline orientation
    6.
    发明申请
    Method and mould for casting articles with a pre-determined crytalline orientation 有权
    用预先确定的crytalline取向铸造制品的方法和模具

    公开(公告)号：US20080282972A1

    公开(公告)日：2008-11-20

    申请号：US12219801

    申请日：2008-07-29

    申请人： Neil J. D'Souza ,  Philip A. Jennings ,  Keerthi Devendra

    发明人： Neil J. D'Souza ,  Philip A. Jennings ,  Keerthi Devendra

    IPC分类号： C30B28/10

    CPC分类号： C30B11/14 ,  C30B29/52 ,  F01D5/28 ,  F05D2230/211 ,  F05D2300/606 ,  F05D2300/607 ,  Y10T117/10 ,  Y10T117/1016 ,  Y10T117/1036

    摘要： Previously a number of techniques have been used in order to form single crystal or pre-determined crystallography components and articles. Each one of these techniques has its own particular problems, including susceptibility to error. By utilisation of a bi-crystal experiment to determine melt-back length LM and by consideration of the ingress distance d from potential initiation nucleation points on a perimeter of a seed crystal, it is possible to determine a maximum ingress length d. By ensuring that the maximum ingress length d is less than or equal to a seed crystal diameter R, it is possible to project locus from potential nucleation points C1, C2 in terms of potential radii for stray grain propagation. As the seed crystal will have a known crystalline orientation, it will be possible to consider two divergent growth curves of the crystal in terms of the stray grains propagating from the point C1, C2. In such circumstances, a connector channel can be provided with a radius r=R/4 in an area between the periphery of the seed and the locus of the stray grain maximum ingress distances d. In situations where it is found d exceeds the crystal radius R, it will be understood that the actual crystal diameter R used may be increased or adjustment made with regard to the melt-back length LM in order to alter the maximum ingress distance d.

    摘要翻译： 以前已经使用许多技术来形成单晶或预定的晶体学组件和制品。 这些技术中的每一种都有自己的特殊问题，包括对误差的敏感性。 通过利用双晶实验来确定熔体回缩长度LM，并且考虑到晶种周边上潜在的起始成核点的入口距离d，可以确定最大入口长度d。 通过确保最大入口长度d小于或等于籽晶直径R，可以将位点从潜在成核点C 1，C 2 2投影到 杂散粒子传播的潜在半径条件。 由于晶种将具有已知的晶体取向，所以可以考虑晶体的两个发散生长曲线，就是从点C 1，C 2 2传播的杂散晶粒， / SUB>。 在这种情况下，连接器通道可以在种子周边与杂散颗粒最大进入距离d的轨迹之间的区域中具有半径r = R / 4。 在发现d超过晶体半径R的情况下，可以理解，为了改变最大入口距离d，所使用的实际晶体直径R可以增加或相对于熔体返回长度LM进行调整。

    Endonucleases
    7.
    发明授权
    Endonucleases 失效
    核酸内切酶

    公开(公告)号：US5298612A

    公开(公告)日：1994-03-29

    申请号：US717602

    申请日：1991-06-19

    申请人： Philip A. Jennings ,  Masine J. McCall ,  Philip Hendry

    发明人： Philip A. Jennings ,  Masine J. McCall ,  Philip Hendry

    IPC分类号： A61K38/46 ,  A61K38/00 ,  A61P17/00 ,  A61P31/12 ,  C12N9/00 ,  C12N9/22 ,  C12N15/113 ,  C12N15/10

    CPC分类号： C12N15/113 ,  C12N9/22 ,  A61K38/00 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/322

    摘要： This invention provides catalytic molecules capable of cleaving target nucleotide sequences. More specifically, the invention provides an endonuclease having nucleotide sequences which are of sufficient length to allow hybridisation to a target nucleotide sequence desired to be cleaved. The endonuclease contains a catalytic region comprising ribonucleotides and/or deoxyribonucleotides, or derivatives thereof which act to cleave a phosphodiester bond of the substrate nucleotide sequence. The catalytic region comprises nucleotides or derivatives thereof which are linked by linking groups which may comprise ribonucleotides, deoxyribonucleotides or combinations thereof.The endonucleases of the invention are useful in the cleavage of target RNAs associated with disease in humans and animals and in the inactivation of RNA transcripts in eukaryotic and prokaryotic cells, as well as the cleavage of RNA transcripts in-vitro.

    摘要翻译： 本发明提供能够切割靶核苷酸序列的催化分子。 更具体地，本发明提供了具有足够长度的核苷酸序列的核酸内切核酸酶，以允许与期望切割的靶核苷酸序列杂交。 核酸内切酶含有包含核糖核苷酸和/或脱氧核糖核苷酸或其衍生物的催化区，其作用是切割底物核苷酸序列的磷酸二酯键。 催化区域包含通过可包含核糖核苷酸，脱氧核糖核苷酸或其组合的连接基团连接的核苷酸或其衍生物。 本发明的核酸内切酶可用于在人类和动物中与疾病相关的靶RNA的切割和真核和原核细胞中的RNA转录物的失活以及在体外切割RNA转录物。