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公开(公告)号：US5254678A
公开(公告)日：1993-10-19
申请号：US926148
申请日：1992-08-05
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N15/11 , C12N15/70 , C12N15/74 , C12N15/79
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
摘要翻译： 描述具有高度特异性内切核糖核酸酶活性的化合物。 本发明的化合物也称为核酶，其包含具有两个具有能够与靶RNA杂交的预定序列的区域的核糖核苷酸，定义的序列区域和碱基配对的茎区域。
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公开(公告)号：US5574143A
公开(公告)日：1996-11-12
申请号：US195735
申请日：1994-02-08
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N9/10 , A61K38/45 , C12N15/54 , C12N15/64
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
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公开(公告)号：US5543508A
公开(公告)日：1996-08-06
申请号：US195072
申请日：1994-02-08
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N15/11 , C12N15/70 , C12N15/74 , C12N15/79
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise nucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
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公开(公告)号：US5494814A
公开(公告)日：1996-02-27
申请号：US967693
申请日：1992-10-27
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N5/10 , C12N9/22 , C12N15/54 , C12Q1/68
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise ribonucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
摘要翻译： 描述具有高度特异性内切核糖核酸酶活性的化合物。 本发明的化合物也称为核酶，其包含具有两个具有能够与靶RNA杂交的预定序列的区域的核糖核苷酸，定义的序列区域和碱基配对的茎区域。
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公开(公告)号：US5589580A
公开(公告)日：1996-12-31
申请号：US195747
申请日：1994-02-08
IPC分类号： A01N57/16 , A01N63/00 , A61K38/00 , C12N15/113 , C12N15/82 , C12N15/11 , C12N15/70 , C12N15/74 , C12N15/79
CPC分类号： C12N15/113 , A01N57/16 , A01N63/00 , C12N15/8216 , C12N15/8218 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/124
摘要： Compounds having highly specific endoribonuclease activity are described. The compounds of this invention, also known as ribozymes, comprise nucleotides having two hybridizing regions with predetermined sequences capable of hybridizing with a target RNA, a region of defined sequence and a base paired stem region.
摘要翻译： 描述具有高度特异性内切核糖核酸酶活性的化合物。 本发明的化合物，也称为核酶，包含具有两个具有能够与靶RNA杂交的预定序列的两个杂交区域，定义序列区域和碱基配对干区域的核苷酸。
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公开(公告)号：US20090104154A1
公开(公告)日：2009-04-23
申请号：US12292499
申请日：2008-11-20
申请人： Gerald W. Both , Trevor J. Lockett , Peter L. Molloy , Fiona H. Cameron , Pamela J. Russell , Rosetta Martiniello-Wilks , Minoo J. Moghaddam , Ian K. Smith
发明人： Gerald W. Both , Trevor J. Lockett , Peter L. Molloy , Fiona H. Cameron , Pamela J. Russell , Rosetta Martiniello-Wilks , Minoo J. Moghaddam , Ian K. Smith
IPC分类号： A61K35/76
CPC分类号： A61K35/761 , A61K38/45 , A61K45/06 , A61K47/67 , A61K47/6901 , A61K48/00 , A61K48/0041 , B82Y5/00 , C12N7/00 , C12N15/86 , C12N2710/10132 , C12N2710/10143 , C12N2830/008 , C12N2830/15 , A61K2300/00
摘要： The present invention provides a method of treating a solid tumour in a subject, the method comprising the following steps (i) delivering to the solid tumour a composition comprising an engineered ovine atadenovirus; and (ii) administering a prodrug to the subject, wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts the prodrug to a cytotoxic metabolite, the gene being under control of the promoter.
摘要翻译： 本发明提供一种治疗受试者的实体肿瘤的方法，所述方法包括以下步骤：（i）向实体瘤递送包含工程改造的腺癌腺病毒的组合物; 并且（ii）向所述受试者施用前药，其中所述工程改造的腺癌腺病毒包含启动子和编码将所述前药转化为细胞毒性代谢物的酶的基因，所述基因处于所述启动子的控制之下。
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