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公开(公告)号:US20170114125A1
公开(公告)日:2017-04-27
申请号:US15331881
申请日:2016-10-23
申请人: Roger A. SABBADINI , Rosalia MATTEO , Genevieve HANSEN , William Arthur GARLAND , James Stephen SWANEY
发明人: Roger A. SABBADINI , Rosalia MATTEO , Genevieve HANSEN , William Arthur GARLAND , James Stephen SWANEY
IPC分类号: C07K16/18 , G01N33/574 , G01N33/92
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12Q1/6883 , C12Q1/6886 , G01N33/574 , G01N33/92 , G01N2405/04 , G01N2800/102 , G01N2800/2842
摘要: Methods for preventing or treating pain are provided, comprising administering to a subject, including a human subject, an antibody or antibody fragment that binds LPA.
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2.
公开(公告)号:US20100034814A1
公开(公告)日:2010-02-11
申请号:US12406874
申请日:2009-03-18
申请人: Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , James Stephen SWANEY , Rosalia MATTEO , Gordon MILLS , Jonathan Michael WOJCIAK
发明人: Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , James Stephen SWANEY , Rosalia MATTEO , Gordon MILLS , Jonathan Michael WOJCIAK
CPC分类号: C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6883 , C12Q1/6886 , G01N33/92
摘要: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
摘要翻译: 描述了用于制备和使用抗LPA剂的组合物和方法,例如单克隆抗体。 公开了针对LPA的几种单克隆抗体的可变结构域和互补决定区氨基酸序列,以及共有抗LPA单克隆抗体可变结构域序列。
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公开(公告)号:US20090136483A1
公开(公告)日:2009-05-28
申请号:US12129109
申请日:2008-05-29
CPC分类号: G01N33/92 , A61K2039/505 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/54386 , G01N33/577 , G01N2405/04
摘要: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
摘要翻译: 描述了用于制备和使用抗LPA剂的组合物和方法,例如单克隆抗体。
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4.
公开(公告)号:US20160152735A1
公开(公告)日:2016-06-02
申请号:US14862117
申请日:2015-09-22
申请人: Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , James Stephen SWANEY , Rosalia MATTEO , Gordon MILLS , Jonathan Michael WOJCIAK
发明人: Roger A. SABBADINI , William A. GARLAND , Genevieve HANSEN , James Stephen SWANEY , Rosalia MATTEO , Gordon MILLS , Jonathan Michael WOJCIAK
IPC分类号: C07K16/44
CPC分类号: C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6883 , C12Q1/6886 , G01N33/92
摘要: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
摘要翻译: 描述了用于制备和使用抗LPA剂的组合物和方法,例如单克隆抗体。 公开了针对LPA的几种单克隆抗体的可变结构域和互补决定区氨基酸序列,以及共有抗LPA单克隆抗体可变结构域序列。
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公开(公告)号:US20120195901A1
公开(公告)日:2012-08-02
申请号:US13448269
申请日:2012-04-16
IPC分类号: A61K39/395 , C12N7/01 , C12N5/10 , C12N1/15 , C12N1/21 , C12N1/19 , C12N15/63 , A61K31/66 , C07K16/00 , C07H21/04 , C07C69/52 , A61P35/00 , A61P37/02 , A61P41/00 , A61P25/28 , A61P3/04 , A61P3/10 , A61P27/02 , A61P13/12 , A61P17/00 , A61P9/00 , A61P17/02 , G01N33/566
CPC分类号: G01N33/92 , A61K2039/505 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/54386 , G01N33/577 , G01N2405/04
摘要: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
摘要翻译: 描述了用于制备和使用抗LPA剂的组合物和方法,例如单克隆抗体。
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公开(公告)号:US09163091B2
公开(公告)日:2015-10-20
申请号:US12406874
申请日:2009-03-18
申请人: Roger A. Sabbadini , William A. Garland , James Stephen Swaney , Rosalia Matteo , Gordon Mills , Jonathan Michael Wojciak
发明人: Roger A. Sabbadini , William A. Garland , Genevieve Hansen , James Stephen Swaney , Rosalia Matteo , Gordon Mills , Jonathan Michael Wojciak
CPC分类号: C07K16/44 , A61K2039/505 , C07K16/18 , C07K16/3076 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12Q1/6883 , C12Q1/6886 , G01N33/92
摘要: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
摘要翻译: 描述了用于制备和使用抗LPA剂的组合物和方法,例如单克隆抗体。 公开了针对LPA的几种单克隆抗体的可变结构域和互补决定区氨基酸序列,以及共有抗LPA单克隆抗体可变结构域序列。
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7.LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS OR DISEASES OF THE EYE 审中-公开
标题翻译: 用于治疗眼睛病情或疾病的赖氨酸磷酸受体拮抗剂公开(公告)号:US20130253019A1
公开(公告)日:2013-09-26
申请号:US13704276
申请日:2011-06-13
IPC分类号: A61K31/42 , A61K31/4245
CPC分类号: A61K31/42 , A61K31/4245 , A61K31/74
摘要: Described herein is the use of LPA1 antagonists in the treatment or prevention of diseases or conditions of the eye of a mammal. Also described are pharmaceutical compositions that include at least one LPA1 antagonist.
摘要翻译: 本文描述了LPA1拮抗剂在治疗或预防哺乳动物眼睛疾病或病症中的用途。 还描述了包含至少一种LPA1拮抗剂的药物组合物。
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公开(公告)号:US08158124B2
公开(公告)日:2012-04-17
申请号:US12129109
申请日:2008-05-29
IPC分类号: C07K16/00
CPC分类号: G01N33/92 , A61K2039/505 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/54386 , G01N33/577 , G01N2405/04
摘要: Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.
摘要翻译: 描述了用于制备和使用抗LPA剂的组合物和方法,例如单克隆抗体。
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