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公开(公告)号:US06953792B2
公开(公告)日:2005-10-11
申请号:US10276129
申请日:2001-05-16
申请人: Jose Luis Castro Pineiro , Kevin Dinnell , Jason Matthew Elliot , Gregory John Hollingworth , Duncan Edward Shaw , Christopher John Swain , Lihu Yang
发明人: Jose Luis Castro Pineiro , Kevin Dinnell , Jason Matthew Elliot , Gregory John Hollingworth , Duncan Edward Shaw , Christopher John Swain , Lihu Yang
IPC分类号: C07D295/04 , A61K31/075 , A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/341 , A61K31/357 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/4164 , A61K31/4196 , A61K31/4355 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/451 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P1/08 , A61P25/04 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , A61P43/00 , C07C43/178 , C07C45/29 , C07C49/497 , C07C49/517 , C07C49/697 , C07C49/747 , C07C49/753 , C07C69/757 , C07C69/767 , C07C217/48 , C07C217/52 , C07C229/22 , C07C233/23 , C07C233/31 , C07C233/32 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/80 , C07C235/82 , C07C237/04 , C07C237/08 , C07C237/24 , C07D207/06 , C07D207/16 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/74 , C07D213/38 , C07D217/04 , C07D233/90 , C07D241/08 , C07D257/04 , C07D265/30 , C07D275/04 , C07D277/28 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/192 , C07D295/205 , C07D307/52 , C07D317/72 , C07D333/20 , C07D401/04 , C07D401/06 , C07D413/04 , C07D417/12 , C07D487/08 , C07D491/20 , C07D295/16
CPC分类号: C07D295/185 , C07B2200/09 , C07C45/29 , C07C49/697 , C07C49/747 , C07C49/753 , C07C217/52 , C07C233/23 , C07C233/31 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/82 , C07C237/04 , C07C237/24 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/48 , C07D211/58 , C07D213/38 , C07D241/08 , C07D295/096 , C07D295/15 , C07D295/155 , C07D295/192 , C07D295/205 , C07D401/06 , C07C47/228
摘要: The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
摘要翻译: 本发明涉及式(I)的化合物:其中环A为苯基或吡啶环; X代表选自(a),(b),(c),(d),(e),(f),(g),(h),(i),(j) ,(k),(1)和R 1,R 2,R 3,R 4,R R 5,R 6,R 7,R 13,R 14,R 14, R 16,R 16,R 17,R 18,R 19,R 21a, SUP>和R 21b如本文所定义。 该化合物特别用于治疗或预防抑郁,焦虑,疼痛,炎症,偏头痛,呕吐或带状疱疹后神经痛。