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公开(公告)号：US08114973B2
公开(公告)日：2012-02-14
申请号：US12244698
申请日：2008-10-02
申请人： Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
发明人： Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
CPC分类号： C07H21/04
摘要： The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译： 本发明提供核苷酸类似物及其使用方法，例如用于测序核酸。
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公开(公告)号：US08071755B2
公开(公告)日：2011-12-06
申请号：US12098196
申请日：2008-04-04
申请人： J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
发明人： J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
IPC分类号： C07H21/00
CPC分类号： C07H21/04
摘要： The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译： 本发明提供核苷酸类似物及其使用方法，例如用于测序核酸。
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公开(公告)号：US20090186351A1
公开(公告)日：2009-07-23
申请号：US12244698
申请日：2008-10-02
申请人： Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
发明人： Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
CPC分类号： C07H21/04
摘要： The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译： 本发明提供核苷酸类似物及其使用方法，例如用于测序核酸。
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公开(公告)号：US20190249173A1
公开(公告)日：2019-08-15
申请号：US16098658
申请日：2017-05-03
申请人： Chandra VARGEESE , Jason Jingxin ZHANG , Sethumadhavan DIVAKARAMENON , David Charles Donnell BUTLER , Genliang LU , Naoki IWAMOTO , Hailin YANG , Maria David FRANK-KAMENETSKY , Subramanian MARAPPAN , WAVE LIFE SCIENCES LTD.
发明人： Chandra Vargeese , Jason Jingxin Zhang , Sethumadhavan Divakaramenon , David Charles Donnell Butler , Genliang Lu , Naoki Iwamoto , Hailin Yang , Maria David Frank-Kamenetsky , Subramanian Marappan
IPC分类号： C12N15/11 , A61K31/7088 , A61K47/54
CPC分类号： C12N15/111 , A61K31/7088 , A61K47/542 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/16 , C12N2310/20 , C12N2310/315 , C12N2310/3515 , C12N2320/32
摘要： In some embodiments, the present disclosure pertains to compositions and methods related to delivery of a biologically active agent, wherein the compositions comprise a biologically active agent and a lipid. In various embodiments, the lipid is selected from: lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, docosa-hexaenoic acid (cis-DHA), turbinaric acid and dilinoleyl. In some embodiments, a composition and method are useful for delivery of a biologically active agent to a particular cell or tissue, e.g., a muscle cell or tissue.
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公开(公告)号：US20120040340A1
公开(公告)日：2012-02-16
申请号：US13283220
申请日：2011-10-27
申请人： J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
发明人： J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
CPC分类号： C07H21/04
摘要： The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译： 本发明提供核苷酸类似物及其使用方法，例如用于测序核酸。
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公开(公告)号：US20110070192A1
公开(公告)日：2011-03-24
申请号：US10578850
申请日：2004-11-08
申请人： Bruno Tse , Borcherng Hong , Wei-Hung Chen , Yea-Fen Jiang , Shuo-Cang Zhang , Subramanian Marappan , Sepehr Sarshar
发明人： Bruno Tse , Borcherng Hong , Wei-Hung Chen , Yea-Fen Jiang , Shuo-Cang Zhang , Subramanian Marappan , Sepehr Sarshar
IPC分类号： A61K38/21 , C07H19/09 , A61K31/7072 , C07H21/00 , C07D403/14 , A61K31/515 , A61K31/513 , C07F7/10 , A61K31/695 , C07H19/19 , A61K31/708 , C07D473/32 , A61K31/522 , A61K31/282 , A61K33/24 , A61K31/664 , A61K31/7068 , A61K31/4985 , A61P3/10 , A61P31/00 , A61P35/00 , C12N5/071 , C12Q1/70 , C12Q1/68
CPC分类号： C07D473/00 , C07D405/04 , C07D493/04
摘要： Processes for the preparation of racemic and optically active nucleoside analogs of formula (A) are described. These compounds are useful as anti-infective agents, antisense therapeutic agents and hybridization assay probes.
摘要翻译： 描述了制备式（A）的外消旋和光学活性核苷类似物的方法。 这些化合物可用作抗感染剂，反义治疗剂和杂交测定探针。
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公开(公告)号：US07691904B2
公开(公告)日：2010-04-06
申请号：US11881143
申请日：2007-07-24
IPC分类号： A61K31/165 , A61K31/216 , C07C233/02 , C07C69/712
CPC分类号： C07D295/18
摘要： The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
摘要翻译： 本发明涉及2,6-二异丙基苯酚（Propofol）的水溶性衍生物。 该化合物作为2,6-二异丙基苯酚的前体药物，并快速代谢到丙泊酚，从而提供了不溶于水的2,6-二异丙基苯酚的替代物。 还公开了包含这些化合物的药物组合物，诱导和维持麻醉或镇静的方法以及利用包含这些化合物的药物组合物治疗神经变性疾病的方法及其制备方法。
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8.发明申请Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions 审中-公开捕获化合物，其收集物和分析蛋白质组合物和复合物组合物的方法公开(公告)号：US20050042771A1
公开(公告)日：2005-02-24
申请号：US10760085
申请日：2004-01-16
申请人： Hubert Koster , Daniel Little , Suhaib Siddiqi , Matthew Grealish , Subramanian Marappan , Chester Hassman , Ping Yip
发明人： Hubert Koster , Daniel Little , Suhaib Siddiqi , Matthew Grealish , Subramanian Marappan , Chester Hassman , Ping Yip
IPC分类号： C07C69/76 , C07C69/96 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/06 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D495/04 , C07D498/18 , C07D519/00 , G01N33/68 , G01N33/543
CPC分类号： C07D495/04 , C07C69/76 , C07C69/96 , C07C2603/74 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D417/12 , C07D417/14 , C07D519/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
摘要翻译： 提供捕获化合物及其收集物和使用该化合物分析生物分子的方法。 特别地，提供收集，化合物和方法用于分析复合蛋白质混合物，例如蛋白质组。 这些化合物是提供复杂蛋白质混合物分离和分离的多功能试剂。 还提供了用于执行方法的自动化系统。
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9.发明授权Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions 有权捕获化合物，其收集物和分析蛋白质组合物和复合物组合物的方法公开(公告)号：US09034798B2
公开(公告)日：2015-05-19
申请号：US12660511
申请日：2010-02-26
申请人： Hubert Köster , Daniel Paul Little , Suhaib Mahmood Siddiqi , Matthew Peter Grealish , Subramanian Marappan , Chester Frederick Hassman, III , Ping Yip
发明人： Hubert Köster , Daniel Paul Little , Suhaib Mahmood Siddiqi , Matthew Peter Grealish , Subramanian Marappan , Chester Frederick Hassman, III , Ping Yip
IPC分类号： G01N33/68 , C07D495/04 , C07C69/76 , C07C69/96 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D417/12 , C07D417/14 , C07D519/00
CPC分类号： C07D495/04 , C07C69/76 , C07C69/96 , C07C2603/74 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D417/12 , C07D417/14 , C07D519/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
摘要翻译： 提供捕获化合物及其收集物和使用该化合物分析生物分子的方法。 特别地，提供收集，化合物和方法用于分析复合蛋白质混合物，例如蛋白质组。 这些化合物是提供复杂蛋白质混合物分离和分离的多功能试剂。 还提供了用于执行方法的自动化系统。
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公开(公告)号：US07994304B2
公开(公告)日：2011-08-09
申请号：US11929084
申请日：2007-10-30
申请人： Suhaib Siddiqi , Hernan Orgueira , Edyta Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
发明人： Suhaib Siddiqi , Hernan Orgueira , Edyta Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
IPC分类号： C07H21/04
CPC分类号： C07H21/04
摘要： The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
摘要翻译： 本发明提供了可用于测序含有例如两个或多个碱基重复序列的均聚物区域的核酸的拴系核苷酸类似物家族，以及使用这种拴系的核苷酸类似物的测序方法。
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