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公开(公告)号：US20230203087A1
公开(公告)日：2023-06-29
申请号：US17926987
申请日：2021-05-24
申请人： Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Chandra Vargeese , Subramanian Marappan , Gopal Bommineni , Mamoru Shimizu , Naoki Iwamoto , Stephany Standley , Yuanjing Liu , Amy Jada Andreucci , Genliang LU , Onanong Chivatakarn , Akbar Husain Khan , WAVE LIFE SCIENCES LTD.
发明人： Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Chandra Vargeese , Subramanian Marappan , Gopal Reddy Bommineni , Mamoru Shimizu , Naoki Iwamoto , Stephany Michelle Standley , Yuanjing Liu , Amy Jada Andreucci , Genliang Lu , Onanong Chivatakarn , Akbar Husain Khan
IPC分类号： C07H21/04 , C07F9/165 , C07D295/02
CPC分类号： C07H21/04 , C07F9/165 , C07D295/02
摘要： The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.
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公开(公告)号：US20230220384A1
公开(公告)日：2023-07-13
申请号：US17766677
申请日：2020-10-06
申请人： Prashant MONIAN , Chikdu Shakti SHIVAILA , Subramanian MARAPPAN , Chandra VARGEESE , Pachamuthu KANDASAMY , Genliang LU , Hui YU , David Charles Donnell BUTLER , Luciano Henrique APPONI , Mamoru SHIMIZU , Stephany Michelle STANDLEY , David John BOULAY , Andrew Guzior HOSS , Jigar DESAI , Jack David GODFREY , Hailin YANG , Naoki IWAMOTO , WAVE LIFE SCIENCES LTD.
发明人： Prashant Monian , Chikdu Shakti Shivalila , Subramanian Marappan , Chandra Vargeese , Pachamuthu Kandasamy , Genliang Lu , Hui Yu , David Charles Donnell Butler , Luciano Henrique Apponi , Mamoru Shimizu , Stephany Michelle Standley , David John Boulay , Andrew Guzior Hoss , Jigar Desai , Jack David Godfrey , Hailin Yang , Naoki Iwamoto
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/351 , C12N2310/314 , C12N2310/322 , C12N2310/321 , C12N2310/315
摘要： Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.
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公开(公告)号：US20230089442A1
公开(公告)日：2023-03-23
申请号：US17439755
申请日：2020-03-19
申请人： Pachamuthu KANDASAMY , Mamoru SHIMIZU , David Charles Donnell BUTLER , Jayakanthan KUMARASAMY , Gopal Reddy BOMMINENI , Mohammed Rowshon ALAM , Sethumadhavan DIVAKARAMENON , Bijay Tilak BHATTARAI , Chandra VARGEESE , Keith Andrew BOWMAN , Stephany Michelle STANDLEY , WAVE LIFE SCIENCES LTD.
发明人： Pachamuthu Kandasamy , Mamoru Shimizu , David Charles Donnell Butler , Jayakanthan Kumarasamy , Gopal Reddy Bommineni , Mohammed Rowshon Alam , Sethumadhavan Divakaramenon , Bijay Tilak Bhattarai , Chandra Vargeese , Keith Andrew Bowman , Stephany Michelle Standley
摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
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公开(公告)号：US20200231620A1
公开(公告)日：2020-07-23
申请号：US16648146
申请日：2018-09-17
申请人： Keith Andrew BOWMAN , Chandra VARGEESE , David Charles Donnell BUTLER , Pachamuthu KANDASAMY , Mohammed Rowshon ALAM , Mamoru SHIMIZU , Stephany Michelle STANDLEY , Vincent ADUDA , Gopal Reddy BOMMINENI , Snehlata TRIPATHI , Ilia KORBOUKH , WAVE LIFE SCIENCES LTD.
发明人： Keith Andrew Bowman , Chandra Vargeese , David Charles Donnell Butler , Pachamuthu Kandasamy , Mohammed Rowshon Alam , Mamoru Shimizu , Stephany Michelle Standley , Vincent Aduda , Gopal Reddy Bommineni , Snehlata Tripathi , Ilia Korboukh
摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
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公开(公告)号：US20230348524A1
公开(公告)日：2023-11-02
申请号：US18185901
申请日：2023-03-17
发明人： Keith Andrew Bowman , Chandra Vargeese , David Charles Donnell Butler , Pachamuthu Kandasamy , Mohammed Rowshon Alam , Mamoru Shimizu , Stephany Michelle Standley , Vincent Aduda , Gopal Reddy Bommineni , Snehlata Tripathi , Ilia Korboukh
摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
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公开(公告)号：US11608355B2
公开(公告)日：2023-03-21
申请号：US16648146
申请日：2018-09-17
发明人： Keith Andrew Bowman , Chandra Vargeese , David Charles Donnell Butler , Pachamuthu Kandasamy , Mohammed Rowshon Alam , Mamoru Shimizu , Stephany Michelle Standley , Vincent Aduda , Gopal Reddy Bommineni , Snehlata Tripathi , Ilia Korboukh
摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
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公开(公告)号：US20230329201A1
公开(公告)日：2023-10-19
申请号：US18022509
申请日：2021-08-23
发明人： Hailin Yang , Prashant Monian , Chikdu Shakti Shivalila , Subramanian Marappan , Chandra Vargeese , Pachamuthu Kandasamy , Genliang Lu , Hui Yu , David Charles Donnell Butler , Luciano Henrique Apponi , Mamoru Shimizu , Stephany Michelle Standley , David John Boulay , Jack David Godfrey , Naoki Iwanmoto
IPC分类号： A01K67/027 , C12N15/85 , C12N9/78 , A61K49/00
CPC分类号： A01K67/0275 , A61K49/0008 , C12N9/78 , C12N15/8509 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C12N2015/8518
摘要： Among other things, the present disclosure provides cells and non-human animals engineered to express an ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, the present disclosure provides cells and non-human animals engineered to express a human ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, non-human animals are genetically modified rodents such as mice, rat, etc. In some embodiments, non-human animals are mice. In some embodiments, the present disclosure provides technologies for assessing an agent comprising administering the agent to a cell or non-human animal engineered to express an ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, such a cell or non-human animal is engineered to express a human ADAR1 polypeptide or a characteristic portion thereof. In some embodiments, an agent is a pharmaceutical agent. In some embodiments, an agent is or comprises an oligonucleotide.
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公开(公告)号：US20240026358A1
公开(公告)日：2024-01-25
申请号：US18252029
申请日：2022-03-11
发明人： Prashant Monian , Chikdu Shakti Shivalila , Subramanian Marappan , Chandra Vargeese , Pachamuthu Kandasamy , Genliang Lu , Hui Yu , David Charles Donnell Butler , Luciano Henrique Apponi , Mamoru Shimizu , Stephany Michelle Standley , David John Boulay , Andrew Guzior Hoss , Jigar Desai , Jack David Godfrey , Hailin Yang , Naoki Iwamoto , Jayakanthan Kumarasamy , Anthony Lamattina , Tom Liantang Pu
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/322 , C12N2310/321 , C12N2310/315 , C12N2320/34
摘要： Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.
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公开(公告)号：US20230392137A1
公开(公告)日：2023-12-07
申请号：US17953292
申请日：2022-09-26
发明人： Prashant Monian , Chikdu Shakti Shivalila , Subramanian Marappan , Chandra Vargeese , Pachamuthu Kandasamy , Genliang Lu , Hui Yu , David Charles Donnell Butler , Luciano Henrique Apponi , Mamoru Shimizu , Stephany Michelle Standley , David John Boulay , Andrew Guzior Hoss , Jigar Desai , Jack David Godfrey , Hailin Yang , Naoki Iwamoto , Jayakanthan Kumarasamy , Anthony Lamattina , Tom Liantang Pu
IPC分类号： C12N15/10 , C12N15/113
CPC分类号： C12N15/102 , C12N15/1135
摘要： Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.
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