公开(公告)号：US10315990B2

公开(公告)日：2019-06-11

申请号：US15550783

申请日：2016-02-03

Applicant: DRIVINGFORCE THERAPEUTICS Co., Ltd.

Inventor： Yongliang Yang

IPC: A61K31/26 ,  A61K31/428 ,  C07C331/22 ,  C07C331/24 ,  C07D213/71 ,  C07D215/36 ,  C07D235/28 ,  C07D239/74 ,  C07D257/04 ,  C07D277/76 ,  C07D311/14 ,  C07D295/096

Abstract: The present invention provides an isothiocyanate compound and its application. The compound is an aryl-substituted isothiocyanate compound that has a structure of the general formula I. The isothiocyanate compound of the present invention has very good solubility in water, far better inhibitory activity for XPO1 protein than other non-aryl substituted congeneric compounds, little side effects, and good biological safety and bioavailability, and is quite suitable for clinical application. Therefore, the isothiocyanate compound would have tremendous potential market space and economic benefits.

公开(公告)号：US20160016901A1

公开(公告)日：2016-01-21

申请号：US14772943

申请日：2014-02-28

Applicant: ASAHI KASEI CHEMICALS CORPORATION

Inventor： Masaaki SHINOHATA ,  Yuji KOSUGI ,  Nobuhisa MIYAKE

IPC: C07C331/30 ,  C07C331/22 ,  C07C333/04 ,  C07C333/22 ,  C07C333/24 ,  C07C333/08 ,  C07C331/20 ,  C07C333/20

CPC classification number: C07C331/30 ,  C07C329/04 ,  C07C331/20 ,  C07C331/22 ,  C07C333/04 ,  C07C333/06 ,  C07C333/08 ,  C07C333/20 ,  C07C333/22 ,  C07C333/24 ,  C07C335/08 ,  C07C335/10 ,  C07C335/14 ,  C07C335/16 ,  C07C2601/14

Abstract: The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

Abstract translation: 本发明涉及使用有机伯胺和硫脲作为原料的异硫氰酸酯的制备方法; 涉及用于运输和储存包含N-取代的O-取代的硫代氨基甲酸酯和羟基化合物的N-取代的O-取代的硫代氨基甲酸酯的组合物，羟基化合物的羟基相对于N的氨基甲酸酯基团的当量重量比 取代的O-取代的硫代氨基甲酸酯在1至100的范围内; 涉及一种用于将包含硫脲基和羟基化合物的化合物的硫脲基的化合物输送和储存的组合物，羟基化合物的羟基相对于硫脲基的硫脲基的当量重量比 在1到100的范围内; 和含有异硫氰酸酯和具有特定官能团的化合物的异硫氰酸酯组合物。

公开(公告)号：US20140107367A1

公开(公告)日：2014-04-17

申请号：US14113739

申请日：2012-04-24

Applicant: Thomas Himmler ,  Matthias Decker ,  Ralf Dunkel ,  Peter Gerdes ,  Martin Littmann ,  Norbert Lui ,  Albert Schnatterer

Inventor： Thomas Himmler ,  Matthias Decker ,  Ralf Dunkel ,  Peter Gerdes ,  Martin Littmann ,  Norbert Lui ,  Albert Schnatterer

IPC: C07C331/22

CPC classification number: C07C331/22

Abstract: A process is described for producing 2-chloroallyl isothiocyanate from 2,3-dichloro-1-propene by reacting the 2,3-dichloro-1-propene with a thiocyanate in the presence of a phase transfer catalyst, without diluent or in the presence of up to 15 percent by weight based on 2,3-dichloropropene and simultaneously in the presence of an excess of from 10 to 200 mol percent of 2,3-dichloro-1-propene based on the thiocyanate. A process starting from 1,2,3-trichloropropane is also described.

Abstract translation: 描述了通过2,3-二氯-1-丙烯通过在相转移催化剂存在下使2,3-二氯-1-丙烯与硫氰酸酯反应而无稀释剂或在存在下进行的制备2-氯烯丙基异硫氰酸酯的方法 基于2,3-二氯丙烯高达15重量％，同时在过量的10至200摩尔％的基于硫氰酸盐的2,3-二氯-1-丙烯的存在下。 还描述了从1,2,3-三氯丙烷开始的方法。

公开(公告)号：US06972111B1

公开(公告)日：2005-12-06

申请号：US09936124

申请日：2000-03-10

Applicant: Franz Kunisch ,  Martin Kugler ,  Jean-Claude Braekman ,  Mark Plehiers ,  Gabriele Ferrari ,  Marcel Vos

Inventor： Franz Kunisch ,  Martin Kugler ,  Jean-Claude Braekman ,  Mark Plehiers ,  Gabriele Ferrari ,  Marcel Vos

IPC: C07C291/10 ,  A01N37/18 ,  A01N37/34 ,  A01N47/40 ,  A01N47/44 ,  A01N47/46 ,  A01N47/48 ,  C07C233/02 ,  C07C265/08 ,  C07C331/20 ,  C07C331/22 ,  C07C331/24 ,  C09D5/16 ,  B08B17/00

CPC classification number: A01N37/34 ,  A01N37/18 ,  A01N47/40 ,  A01N47/44 ,  A01N47/46 ,  C07C233/02 ,  C07C265/08 ,  C07C331/24 ,  C07C2603/26 ,  C09D5/1625

Abstract: The invention relates to new and known compounds as well as methods for preventing the attachment of aquatic organisms to surfaces which are submerged for extensive periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with new isonitrile, formamide, isocyanate and isothiocyanate anti-fouling agents.

Abstract translation: 本发明涉及新的和已知的化合物以及用于防止水生生物附着到在水中浸没大量时间的表面的方法。 更具体地说，本发明涉及用新的异腈，甲酰胺，异氰酸酯和异硫氰酸酯防污剂保护浸没表面。

公开(公告)号：US4794146A

公开(公告)日：1988-12-27

申请号：US89449

申请日：1987-08-20

Applicant: Stanley J. Brois ,  Antonio Gutierrez

Inventor： Stanley J. Brois ,  Antonio Gutierrez

IPC: C07C331/22 ,  C07C335/12 ,  C07D257/02 ,  C07D295/13 ,  C10L1/24 ,  C10M135/14 ,  C08F8/34

CPC classification number: C07D295/13 ,  C07C331/22 ,  C07C335/12 ,  C07D257/02 ,  C10L1/24 ,  C10M135/14 ,  C10M2205/00 ,  C10M2205/026 ,  C10M2207/024 ,  C10M2209/084 ,  C10M2209/086 ,  C10M2215/065 ,  C10M2219/06 ,  C10M2219/062 ,  C10M2219/064 ,  C10M2219/066 ,  C10M2219/082 ,  C10M2219/087 ,  C10M2219/088 ,  C10M2219/089 ,  C10M2219/09 ,  C10M2219/10 ,  C10M2219/102 ,  C10M2219/104 ,  C10M2219/106 ,  C10M2221/00 ,  C10M2221/04 ,  C10M2221/041 ,  C10M2223/045 ,  C10M2223/12 ,  C10M2225/04 ,  C10M2229/02 ,  C10M2229/05 ,  C10N2210/02 ,  C10N2240/06 ,  C10N2240/08 ,  C10N2270/02

Abstract: An oil-soluble additive for lubricating oil applications is provided by the formation of an adduct of thiocyanogen halide and polyalkene, removal of the hydrogen halide from said adduct and thermal rearrangement of the product to provide a polyalkenyl isothiocyanate which can be subsequently derivitized to provide a thiocarbamyl moiety containing product having excellent sludge dispersement properties.

公开(公告)号：US20160000126A1

公开(公告)日：2016-01-07

申请号：US14767566

申请日：2014-02-12

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Yuki OKA ,  Charles ZUKER

IPC: A23L1/22 ,  G01N33/50 ,  C07D285/135 ,  A23L1/237 ,  C07C331/22 ,  C07D495/04

CPC classification number: C07C331/22 ,  A23L27/40 ,  A23L27/45 ,  A23L27/88 ,  A23V2002/00 ,  C07D285/135 ,  C07D495/04 ,  G01N33/5088

Abstract: The current invention is in the field of taste and relates to methods and compositions to modulate the perceived taste of saltiness in food or food products where salty taste is desired. The methods and compositions relate to altering the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1-expressing taste receptor cells. The invention also relates to food and food products containing agents and composition that alter the activation and/or activity of the bitter-sensing taste receptor cells and the PKD2L1-expressing taste receptor cells.

Abstract translation: 本发明是在味道领域中，涉及调节食欲或咸味食品中所需的咸味感觉味道的方法和组合物。 所述方法和组合物涉及改变苦味感受态细胞和表达PKD2L1的味觉受体细胞的活化和/或活性。 本发明还涉及含有改变苦味感受态细胞和表达PKD2L1的味觉受体细胞的活化和/或活性的试剂和组合物的食品和食品。

公开(公告)号：US20130231387A1

公开(公告)日：2013-09-05

申请号：US13806176

申请日：2011-06-20

Applicant: Mingzhan Xue ,  Paul Thornalley ,  Naila Rabbani

Inventor： Mingzhan Xue ,  Paul Thornalley ,  Naila Rabbani

IPC: A61K31/26 ,  C07C331/22 ,  A61K45/06 ,  C07C331/20

CPC classification number: A61K31/26 ,  A61K45/06 ,  C07C331/20 ,  C07C331/22 ,  C12N9/88 ,  C12Q1/25 ,  G01N2500/00 ,  G01N2570/00 ,  A61K2300/00

Abstract: The invention concerns the role of Glo 1 in the prevention and reversal of proteomic and genomic damage by carbonyl substrates thereof and, in particular, therapeutics that promote Glo 1 production.

Abstract translation: 本发明涉及Glo1在其羰基底物，特别是促进Glo1产生的治疗剂中预防和逆转蛋白质组学和基因组损伤的作用。

公开(公告)号：US5254584A

公开(公告)日：1993-10-19

申请号：US993158

申请日：1992-12-18

Applicant: Enrique L. Michelotti ,  Robert R. Raney ,  David H. Young

Inventor： Enrique L. Michelotti ,  Robert R. Raney ,  David H. Young

IPC: A01N37/22 ,  A01N37/34 ,  A01N37/50 ,  A01N41/04 ,  A01N47/46 ,  A01N47/48 ,  A61K31/165 ,  C07C233/76 ,  C07C251/48 ,  C07C251/60 ,  C07C255/17 ,  C07C309/65 ,  C07C309/69 ,  C07C331/04 ,  C07C331/12 ,  C07C331/18 ,  C07C331/22 ,  A01N37/18 ,  C07C235/12

CPC classification number: C07C251/48 ,  A01N37/50 ,  A01N47/48 ,  A61K31/165 ,  C07C331/12

Abstract: Certain N-acetonylbenzamides exhibit low phytotoxicity and are useful for control of a wide range of fungi, including phytopathogenic fungi of the classes Oomycetes, Ascomycetes, Deuteromycetes and Basidiomycetes.

Abstract translation: 某些N-乙酰基苯甲酰胺显示出低的植物毒性，并且可用于控制广泛的真菌，包括类型的子囊菌纲，子囊菌纲，半生菌纲和担子菌纲的致病真菌。

公开(公告)号：US4900749A

公开(公告)日：1990-02-13

申请号：US837192

申请日：1986-03-10

Applicant: Saichi Matsumoto ,  Masami Doteuchi ,  Takuji Mizui ,  Kentaro Hirai

Inventor： Saichi Matsumoto ,  Masami Doteuchi ,  Takuji Mizui ,  Kentaro Hirai

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/22 ,  A61K31/335 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/415 ,  A61K31/495 ,  A61K45/08 ,  A61P1/04 ,  C07C67/00 ,  C07C231/00 ,  C07C233/05 ,  C07C233/65 ,  C07C275/20 ,  C07C275/24 ,  C07C275/28 ,  C07C275/30 ,  C07C313/00 ,  C07C317/44 ,  C07C323/62 ,  C07C325/00 ,  C07C327/40 ,  C07C327/46 ,  C07C327/50 ,  C07C331/22 ,  C07D207/34 ,  C07D209/18 ,  C07D209/28 ,  C07D209/30 ,  C07D209/42 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D233/54 ,  C07D233/60 ,  C07D233/61 ,  C07D241/12 ,  C07D241/24 ,  C07D295/13 ,  C07D295/15 ,  C07D295/215 ,  C07D307/68 ,  C07D317/58 ,  C07D333/38 ,  C07D521/00 ,  C08B37/16

CPC classification number: C07D213/40 ,  C07C275/20 ,  C07C275/24 ,  C07C275/28 ,  C07C275/30 ,  C07C331/22 ,  C07D207/34 ,  C07D209/28 ,  C07D209/30 ,  C07D213/54 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D241/24 ,  C07D249/08 ,  C07D295/13 ,  C07D295/15 ,  C07D295/215 ,  C07D307/68 ,  C07D317/58 ,  C07D333/38

Abstract: Novel isoprenoidamine compounds (I) which show antiulcer activity are provided. ##STR1##

Abstract translation: 提供了具有抗溃疡活性的新型异戊二烯酮化合物（I）。 （一）

公开(公告)号：US2757190A

公开(公告)日：1956-07-31

申请号：US31493952

申请日：1952-10-15

Applicant: DOW CHEMICAL CO

Inventor： JONES GIFFIN D ,  ZIMMERMAN ROBERT L

IPC: C07C331/22 ,  C08F28/00

CPC classification number: C07C331/22 ,  C08F28/00