TYPE LECTIN FOLD AS A SCAFFOLD FOR MASSIVE SEQUENCE VARIATION
    2.
    发明申请
    TYPE LECTIN FOLD AS A SCAFFOLD FOR MASSIVE SEQUENCE VARIATION 有权
    类型LECTIN作为大规模序列变化的SCAFFOLD

    公开(公告)号:US20070275367A1

    公开(公告)日:2007-11-29

    申请号:US11027323

    申请日:2004-12-31

    CPC分类号: C07K14/195 C07K14/001

    摘要: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译: 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白,其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物,以及使用结合蛋白的方法。

    C-type lectin fold as a scaffold for massive sequence variation
    3.
    发明授权
    C-type lectin fold as a scaffold for massive sequence variation 有权
    C型凝集素折叠作为大规模序列变异的支架

    公开(公告)号:US07749694B2

    公开(公告)日:2010-07-06

    申请号:US11027323

    申请日:2004-12-31

    IPC分类号: C12Q1/00 C12Q1/04 A61K38/16

    CPC分类号: C07K14/195 C07K14/001

    摘要: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译: 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白,其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物,以及使用结合蛋白的方法。

    C-Type Lectin Fold as a Scaffold for Massive Sequence Variation
    4.
    发明申请
    C-Type Lectin Fold as a Scaffold for Massive Sequence Variation 审中-公开
    C型凝集素折叠作为大规模序列变异的支架

    公开(公告)号:US20100069300A1

    公开(公告)日:2010-03-18

    申请号:US12493802

    申请日:2009-06-29

    CPC分类号: C07K14/195 C07K14/001

    摘要: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译: 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白,其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物,以及使用结合蛋白的方法。

    Circuit breaker tester including a pulse width modulation circuit

    公开(公告)号:US20070047161A1

    公开(公告)日:2007-03-01

    申请号:US11216727

    申请日:2005-08-31

    IPC分类号: H02H3/00

    CPC分类号: G01R31/3277 H02H1/0015

    摘要: A tester for testing a circuit breaker includes a plurality of load elements each having a nominal fixed impedance and an electronic switch associated with each load element. The electronic switch, when turned on, electrically connects a corresponding load element in series with a circuit breaker load terminal and in parallel with none or with a number of other load elements. A controller turns on a number of the electronic switches selected to draw through a corresponding number of the load elements a test current selected as a function of a designated rated current for the circuit breaker and sufficient to trip open the same. A pulse width modulation circuit cooperates with the controller and with the electronic switches. The pulse width modulation circuit provides a constant magnitude of the test current to accommodate variations of the nominal fixed impedance or variations of the voltage of the load terminal.