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公开(公告)号：US20070275367A1
公开(公告)日：2007-11-29
申请号：US11027323
申请日：2004-12-31
申请人： Partho Ghosh , Stephen McMahon , Jason Miller , Jeffrey Lawton
发明人： Partho Ghosh , Stephen McMahon , Jason Miller , Jeffrey Lawton
IPC分类号： C12Q1/00 , A61K38/16 , C12Q1/04 , C07K14/195
CPC分类号： C07K14/195 , C07K14/001
摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.
摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。
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公开(公告)号：US07749694B2
公开(公告)日：2010-07-06
申请号：US11027323
申请日：2004-12-31
申请人： Partho Ghosh , Stephen McMahon , Jason Miller , Jeffrey Lawton
发明人： Partho Ghosh , Stephen McMahon , Jason Miller , Jeffrey Lawton
CPC分类号： C07K14/195 , C07K14/001
摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.
摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。
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公开(公告)号：US20100069300A1
公开(公告)日：2010-03-18
申请号：US12493802
申请日：2009-06-29
申请人： Partho Ghosh , Stephen McMahon , Jason Miller , Jeffrey Lawton
发明人： Partho Ghosh , Stephen McMahon , Jason Miller , Jeffrey Lawton
CPC分类号： C07K14/195 , C07K14/001
摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.
摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。
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公开(公告)号：US20070047161A1
公开(公告)日：2007-03-01
申请号：US11216727
申请日：2005-08-31
IPC分类号： H02H3/00
CPC分类号： G01R31/3277 , H02H1/0015
摘要： A tester for testing a circuit breaker includes a plurality of load elements each having a nominal fixed impedance and an electronic switch associated with each load element. The electronic switch, when turned on, electrically connects a corresponding load element in series with a circuit breaker load terminal and in parallel with none or with a number of other load elements. A controller turns on a number of the electronic switches selected to draw through a corresponding number of the load elements a test current selected as a function of a designated rated current for the circuit breaker and sufficient to trip open the same. A pulse width modulation circuit cooperates with the controller and with the electronic switches. The pulse width modulation circuit provides a constant magnitude of the test current to accommodate variations of the nominal fixed impedance or variations of the voltage of the load terminal.
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