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    TYPE LECTIN FOLD AS A SCAFFOLD FOR MASSIVE SEQUENCE VARIATION
    1.
    发明申请
    TYPE LECTIN FOLD AS A SCAFFOLD FOR MASSIVE SEQUENCE VARIATION 有权
    类型LECTIN作为大规模序列变化的SCAFFOLD

    公开(公告)号：US20070275367A1

    公开(公告)日：2007-11-29

    申请号：US11027323

    申请日：2004-12-31

    申请人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    发明人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    IPC分类号： C12Q1/00 ,  A61K38/16 ,  C12Q1/04 ,  C07K14/195

    CPC分类号： C07K14/195 ,  C07K14/001

    摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。

    C-type lectin fold as a scaffold for massive sequence variation
    2.
    发明授权
    C-type lectin fold as a scaffold for massive sequence variation 有权
    C型凝集素折叠作为大规模序列变异的支架

    公开(公告)号：US07749694B2

    公开(公告)日：2010-07-06

    申请号：US11027323

    申请日：2004-12-31

    申请人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    发明人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    IPC分类号： C12Q1/00 ,  C12Q1/04 ,  A61K38/16

    CPC分类号： C07K14/195 ,  C07K14/001

    摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。

    C-Type Lectin Fold as a Scaffold for Massive Sequence Variation
    3.
    发明申请
    C-Type Lectin Fold as a Scaffold for Massive Sequence Variation 审中-公开
    C型凝集素折叠作为大规模序列变异的支架

    公开(公告)号：US20100069300A1

    公开(公告)日：2010-03-18

    申请号：US12493802

    申请日：2009-06-29

    申请人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    发明人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    IPC分类号： A61K38/16 ,  C07K14/42 ,  C07H21/04 ,  C12P21/00 ,  G01N33/53 ,  A61P35/00

    CPC分类号： C07K14/195 ,  C07K14/001

    摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。

    APPARATUS FOR DETERMINING GAUGE PROFILE FOR FLAT ROLLED MATERIAL WITH LASER-BASED LAP COUNTER
    8.
    发明申请
    APPARATUS FOR DETERMINING GAUGE PROFILE FOR FLAT ROLLED MATERIAL WITH LASER-BASED LAP COUNTER 审中-公开
    用于确定具有基于激光的拉布计数器的平面滚动材料的量具配置的装置

    公开(公告)号：US20150185147A1

    公开(公告)日：2015-07-02

    申请号：US14658404

    申请日：2015-03-16

    申请人： Jason Miller

    发明人： Jason Miller

    IPC分类号： G01N21/55 ,  G01N29/04

    CPC分类号： G01N29/275 ,  G01B21/08 ,  G01B21/20 ,  G01N2291/02854

    摘要： A gauge profile apparatus (100) includes a gauge profile system (104) and a lap count system (106) for determining an average three-dimensional profile over the length of a sheet coil (10). The gauge profile system (104) includes a lap profile measuring device (112) which will make a distance determination between top and bottom surfaces for the sheet coil (10). A second embodiment of a lap count system (600) is also provided, which utilizes a pair of reflectance lasers and a positioning system.

    摘要翻译： 仪表型材设备（100）包括测量仪轮廓系统（104）和用于确定片状线圈（10）的长度上的平均三维轮廓的搭接计数系统（106）。 测量仪轮廓系统（104）包括搭接轮廓测量装置（112），其将在片状线圈（10）的顶表面和底表面之间进行距离确定。 还提供了一个搭接计数系统（600）的第二个实施例，它利用一对反射激光器和定位系统。

    Apparatus and methods of enhancing radio programming
    10.
    发明授权
    Apparatus and methods of enhancing radio programming 有权
    增强无线电节目的装置和方法

    公开(公告)号：US08744337B2

    公开(公告)日：2014-06-03

    申请号：US12139922

    申请日：2008-06-16

    申请人： Rajeev D. Rajan ,  Jatin Kadakia ,  Jason Miller

    发明人： Rajeev D. Rajan ,  Jatin Kadakia ,  Jason Miller

    IPC分类号： H04H40/36 ,  H04B1/18

    CPC分类号： H04H20/18 ,  H04H20/34 ,  H04H2201/13

    摘要： Apparatus and methods enhancing radio programming include receiving a broadcast radio transmission at a communication device. The broadcast radio transmission includes primary content and supplemental content having a relationship to the primary content. Further, the primary content includes a first audio data, while the supplemental content includes audio data. Additionally, the apparatus and methods include converting the supplemental content into converted supplemental content, maintaining the relationship to the primary content. Moreover, the converted supplemental content includes second audio data converted from the non-audio data. Thus, the described apparatus and methods allow the communication device to output signals for generating audible representations of both the primary content and the supplemental content.

    摘要翻译： 增强无线电节目的装置和方法包括在通信装置处接收广播无线电传输。 广播无线电传输包括主要内容和与主要内容有关系的补充内容。 此外，主要内容包括第一音频数据，而补充内容包括音频数据。 此外，装置和方法包括将补充内容转换为转换的补充内容，维持与主要内容的关系。 此外，转换的补充内容包括从非音频数据转换的第二音频数据。 因此，所描述的装置和方法允许通信设备输出用于生成主要内容和补充内容的可听表示的信号。