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    C-type lectin fold as a scaffold for massive sequence variation
    1.
    发明授权
    C-type lectin fold as a scaffold for massive sequence variation 有权
    C型凝集素折叠作为大规模序列变异的支架

    公开(公告)号：US07749694B2

    公开(公告)日：2010-07-06

    申请号：US11027323

    申请日：2004-12-31

    申请人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    发明人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    IPC分类号： C12Q1/00 ,  C12Q1/04 ,  A61K38/16

    CPC分类号： C07K14/195 ,  C07K14/001

    摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。

    TYPE LECTIN FOLD AS A SCAFFOLD FOR MASSIVE SEQUENCE VARIATION
    2.
    发明申请
    TYPE LECTIN FOLD AS A SCAFFOLD FOR MASSIVE SEQUENCE VARIATION 有权
    类型LECTIN作为大规模序列变化的SCAFFOLD

    公开(公告)号：US20070275367A1

    公开(公告)日：2007-11-29

    申请号：US11027323

    申请日：2004-12-31

    申请人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    发明人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    IPC分类号： C12Q1/00 ,  A61K38/16 ,  C12Q1/04 ,  C07K14/195

    CPC分类号： C07K14/195 ,  C07K14/001

    摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。

    C-Type Lectin Fold as a Scaffold for Massive Sequence Variation
    3.
    发明申请
    C-Type Lectin Fold as a Scaffold for Massive Sequence Variation 审中-公开
    C型凝集素折叠作为大规模序列变异的支架

    公开(公告)号：US20100069300A1

    公开(公告)日：2010-03-18

    申请号：US12493802

    申请日：2009-06-29

    申请人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    发明人： Partho Ghosh ,  Stephen McMahon ,  Jason Miller ,  Jeffrey Lawton

    IPC分类号： A61K38/16 ,  C07K14/42 ,  C07H21/04 ,  C12P21/00 ,  G01N33/53 ,  A61P35/00

    CPC分类号： C07K14/195 ,  C07K14/001

    摘要： This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.

    摘要翻译： 本发明提供一类具有一定范围的结合特异性和亲和力的结合蛋白，其基于在支架内选择性氨基酸位置的变化。 可变位置可以容易地修饰以产生具有不同结合特异性和亲和力的结合蛋白文库。 可以筛选文库以鉴定一个或多个结合目标配体。 还提供了包含结合蛋白的组合物，以及使用结合蛋白的方法。

    System for conducting clinical trials
    5.
    发明申请
    System for conducting clinical trials 审中-公开
    进行临床试验的系统

    公开(公告)号：US20070156459A1

    公开(公告)日：2007-07-05

    申请号：US10536503

    申请日：2003-11-27

    申请人： Stephen McMahon ,  Bruce Neal

    发明人： Stephen McMahon ,  Bruce Neal

    IPC分类号： A61B5/00

    CPC分类号： G06Q50/22 ,  G06Q10/087 ,  G06Q50/24 ,  G16H10/20

    摘要： There is disclosed a system (1) for conducting a clinical trial of a pharmaceutical substance on a plurality of trial participants. The system (1) includes a central database (2) having a memory means in communication with a database means, one or more trial sites each having a remote computer (3) located remotely from the central database (2) and in communication therewith, the central database (2) being configured to receive predetermined parameters of the trial, both the central database (2) and the remote computers (3) being configured to receive predetermined trial data from one or more trial participants, the central database (2) being configured to control and track the ordering, allocation and dispensing of the pharmaceutical substances and compiling a pharmaceutical substance inventory record on the central database, and the central database (2) being configured to terminate the clinical trial in response to one or more predetermined trial termination conditions. A method of conducting a clinical trial of a pharmaceutical substance on a plurality of trial participants is also disclosed.

    摘要翻译： 公开了一种用于在多个试验参与者上进行药物物质的临床试验的系统（1）。 系统（1）包括具有与数据库装置通信的存储装置的中央数据库（2），每个具有远离中央数据库（2）并与之通信的远程计算机（3）的一个或多个试用站， 所述中央数据库（2）被配置为接收所述试用的预定参数，所述中央数据库（2）和所述远程计算机（3）被配置为从一个或多个试用参与者接收预定试用数据，所述中央数据库（2） 被配置为控制和跟踪药物物质的排序，分配和分配以及在中央数据库上编制药物物质清单记录，并且中央数据库（2）被配置为响应于一个或多个预定试验终止临床试验 终止条件。 还公开了在多个试验参与者上进行药物物质的临床试验的方法。

    BROADBAND MULTI-CHANNEL DETECTOR WITH SIGNAL AND JAMMING DISCRIMINATION
    6.
    发明申请
    BROADBAND MULTI-CHANNEL DETECTOR WITH SIGNAL AND JAMMING DISCRIMINATION 审中-公开
    宽带多通道信道检测器，具有信号和串扰

    公开(公告)号：US20080084345A1

    公开(公告)日：2008-04-10

    申请号：US11778992

    申请日：2007-07-17

    申请人： John Rougas ,  Stephen McMahon ,  Douglas Owen

    发明人： John Rougas ,  Stephen McMahon ,  Douglas Owen

    IPC分类号： G01S7/38

    CPC分类号： G01S7/38 ,  H04K3/42 ,  H04K3/43 ,  H04K3/92 ,  H04K3/94 ,  H04K2203/16 ,  H04K2203/24

    摘要： Methods of determining whether a jamming signal strength is adequate, comprising receiving a signal, determining first and second noise power levels of the signal in first and second ranges of frequencies, the first range being broader than and encompassing the second range, and calculating a ratio of the second noise power level divided by the first noise power level. Also, methods of determining whether a jamming signal strength is adequate, comprising receiving a signal, determining a phase difference between first and second frequency range phases of the signal, and calculating a statistical mean and/or a standard deviation of the phase difference. Also, systems for determining whether a jamming signal is adequate, computer-readable media for determining whether jamming signal strength is adequate, systems comprising means for transmitting a jamming signal, and systems comprising means for transmitting and receiving waveforms to users in the presence of protective jamming.

    摘要翻译： 确定干扰信号强度是否足够的方法，包括接收信号，确定所述信号在第一和第二频率范围中的第一和第二噪声功率电平，所述第一范围宽于并包含所述第二范围，并且计算比率 的第二噪声功率电平除以第一噪声功率电平。 此外，确定干扰信号强度是否足够的方法，包括接收信号，确定信号的第一和第二频率范围相位之间的相位差，以及计算相位差的统计平均值和/或标准偏差。 此外，用于确定干扰信号是否足够的系统，用于确定干扰信号强度是否足够的计算机可读介质，包括用于发送干扰信号的装置的系统以及包括用于在存在保护的情况下向用户发送和接收波形的装置的系统 干扰

    Technique for communicating information over a broadband communications network
    7.
    发明申请
    Technique for communicating information over a broadband communications network 有权
    通过宽带通信网络传送信息的技术

    公开(公告)号：US20050114518A1

    公开(公告)日：2005-05-26

    申请号：US10842855

    申请日：2004-05-11

    申请人： Stephen McMahon ,  Edwin Kruse

    发明人： Stephen McMahon ,  Edwin Kruse

    IPC分类号： G06F15/16 ,  H04L29/06 ,  H04M3/42 ,  H04M7/12

    CPC分类号： H04L65/1069 ,  H04L29/06027 ,  H04L65/80 ,  H04M3/4234 ,  H04M7/1215

    摘要： The invention is directed to a technique for enabling communications to be transmitted between at least two associated counterpart devices at different locations, e.g., at work and home. One or more communications devices having a first identification code (e.g., telephone number) applicable to a first communications network are associated with one or more counterpart devices having a second identification code (e.g., Internet Protocol (IP) address) applicable to a second communications network.

    摘要翻译： 本发明涉及一种使得能够在不同位置（例如在工作和家庭）的至少两个相关对应设备之间传送通信的技术。 具有适用于第一通信网络的第一识别码（例如，电话号码）的一个或多个通信设备与具有适用于第二通信的第二识别码（例如，因特网协议（IP）地址）的一个或多个对等设备相关联 网络。

    SYSTEM AND METHOD FOR AUTONOMIC BLOOD PRESSURE REGULATION
    8.
    发明申请
    SYSTEM AND METHOD FOR AUTONOMIC BLOOD PRESSURE REGULATION 审中-公开
    自动血压调节系统及方法

    公开(公告)号：US20140067003A1

    公开(公告)日：2014-03-06

    申请号：US13956344

    申请日：2013-07-31

    申请人： Abhi Vase ,  Stephen McMahon

    发明人： Abhi Vase ,  Stephen McMahon

    IPC分类号： A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/36117 ,  A61B5/0215 ,  A61B5/6876 ,  A61N1/0551

    摘要： A system for regulating blood pressure by stimulating an afferent pathway to the brain which produces an efferent output in kidneys includes a electrode device adapted for implantation in the cervical region, a stimulator generator, a cable connecting the electrode device and the stimulator generator, wherein the cervical region is generally located between a pair of common carotid arteries, above an aortic arch and in front of cervical vertebrae C2 and C3. A method of implantation includes placing the electrode device in the cervical region, selectively energizing the device in accordance with a stimulation scheme, assessing any changes in the patient's blood pressure, selectively energizing the device in accordance with another stimulation scheme, and assessing any changes in the patient's blood, for determining an optical stimulation scheme, wherein stimulation scheme involves parameters including, for example, position, placement and configuration of the electrode device in relation to surrounding tissue and/or organs, selection of electrodes energized, width, frequency and amplitude of stimulation current.

    摘要翻译： 通过刺激在肾中产生输出输出的通向脑的传入途径来调节血压的系统包括适于植入颈部区域的电极装置，刺激器发生器，连接电极装置和刺激器发生器的电缆，其中， 颈部区域通常位于一对颈总动脉之间，主动脉弓上方和颈椎C2和C3前方。 一种植入方法包括将电极装置放置在颈部区域中，根据刺激方案选择性地激励装置，评估患者血压的任何变化，根据另一刺激方案选择性地激励装置，以及评估任何变化 患者的血液，用于确定光学刺激方案，其中刺激方案涉及包括例如相对于周围组织和/或器官的电极装置的位置，放置和配置的参数，通电选择，宽度，频率和幅度 的刺激电流。