公开(公告)号：US07262859B2

公开(公告)日：2007-08-28

申请号：US11250179

申请日：2005-10-13

申请人： Jonathan W. Larson ,  Gregory R. Yantz ,  George Seward ,  David Johnson ,  Jeffrey R. Krogmeier

发明人： Jonathan W. Larson ,  Gregory R. Yantz ,  George Seward ,  David Johnson ,  Jeffrey R. Krogmeier

IPC分类号： G01N21/55 ,  G01N21/01

CPC分类号： G01N21/6452 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/168 ,  B01L2400/0415 ,  B01L2400/0487 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/6463 ,  G01N2021/6469 ,  G01N2021/6478

摘要： The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein.

摘要翻译： 本发明涉及用于检测和/或分析具有并入其中的光学元件的芯片的样品中的试剂的方法和系统。

公开(公告)号：US20130000738A1

公开(公告)日：2013-01-03

申请号：US13406783

申请日：2012-02-28

申请人： Jeffrey R. Krogmeier ,  Robert H. Meltzer ,  Jonathan W. Larson

发明人： Jeffrey R. Krogmeier ,  Robert H. Meltzer ,  Jonathan W. Larson

IPC分类号： F17D3/00

CPC分类号： B01L3/502776 ,  B01L3/021 ,  B01L3/502761 ,  B01L2300/0681 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0415 ,  B01L2400/0487 ,  Y10T137/0329

摘要： A method of controlling the concentration of a sample flowing through a microchannel is provided. The method includes flowing a sample carrier fluid from a sample carrier channel and into an upstream portion of a microchannel such that the sample carrier fluid flows from the upstream portion and toward a downstream portion of the microchannel, and flowing a sheathing fluid from a sheathing fluid channel and into the upstream portion of the microchannel such that the sheathing fluid flows from the upstream portion and toward the downstream portion of the microchannel, and generally parallel to the sample carrier fluid. The method further includes detecting a concentration of a sample in the sample carrier fluid in the downstream portion of the microchannel, and adjusting a flow rate of at least one of the sample carrier fluid and the sheathing fluid based upon the detected concentration of the sample.

摘要翻译： 提供了控制流过微通道的样品浓度的方法。 该方法包括将样品载体流体从样品载体通道流入微通道的上游部分，使得样品载体流体从微通道的上游部分和下游部分流出，并使护套流体从护套流体 通道并进入微通道的上游部分，使得护套流体从微通道的上游部分和下游部分流动，并且通常平行于样品载体流体。 该方法还包括检测微通道下游部分中的样品载体流体中的样品的浓度，并且基于检测到的样品浓度来调节至少一种样品载体流体和护套流体的流速。

公开(公告)号：US20100294665A1

公开(公告)日：2010-11-25

申请号：US12668579

申请日：2008-07-11

申请人： Richard Allen ,  Randall E. Burton ,  Bryan Crane ,  Jeffrey R. Krogmeier ,  Jonathan W. Larson ,  Vyacheslav Papkov ,  Nicaulas Sabourin ,  Qun Zhong ,  Yi Zhou

发明人： Richard Allen ,  Randall E. Burton ,  Bryan Crane ,  Jeffrey R. Krogmeier ,  Jonathan W. Larson ,  Vyacheslav Papkov ,  Nicaulas Sabourin ,  Qun Zhong ,  Yi Zhou

IPC分类号： G01N27/447

CPC分类号： G01N1/40 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0415 ,  G01N2001/4038 ,  G01N2001/4088

摘要： A system for transferring and/or concentrating a sample is provided. The system includes a chamber with a membrane brave positioned within the chamber. An electrode assembly is configured to create an electric field across the membrane to move a charged sample through the chamber such that the sample collects and may concentrate on the membrane. The system may include a plurality of membranes. The system may also include a plurality of microchannels outwardly extending from the channel, where the membrane extends along the plurality of microchannels. Aspects of the invention are also directed to a pipette which may be used to transfer and concentrate a sample on a membrane. Certain embodiments are directed to methods and systems for concentrating a nucleic acid sample.

摘要翻译： 提供了用于转移和/或浓缩样品的系统。 该系统包括具有位于腔室内的膜勇者的腔室。 电极组件被配置为在膜上产生电场以使带电样品移动通过室，使得样品收集并且可以集中在膜上。 该系统可以包括多个膜。 系统还可以包括从通道向外延伸的多个微通道，其中膜沿着多个微通道延伸。 本发明的方面还涉及可用于将样品转移并浓缩在膜上的移液管。 某些实施方案涉及用于浓缩核酸样品的方法和系统。